scholarly journals Impact of interferon-γ release assay on the latent tuberculosis cascade of care: a population-based study

2017 ◽  
Vol 49 (3) ◽  
pp. 1601546 ◽  
Author(s):  
David Z. Roth ◽  
Lisa A. Ronald ◽  
Daphne Ling ◽  
Leslie Y. Chiang ◽  
Victoria J. Cook ◽  
...  
Keyword(s):  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Population Based ◽  
Population Based Study ◽  
Cascade Of Care ◽  
Release Assay

Use of a T Cell Interferon-γ Release Assay to Evaluate Tuberculosis Risk in Newly Qualified Physicians in Singapore Healthcare Institutions

2009 ◽  
Vol 30 (9) ◽  
pp. 870-875 ◽  
Author(s):  
C. B. E. Chee ◽  
L. K. Y. Lim ◽  
T. M. Barkham ◽  
D. R. Koh ◽  
S. O. Lam ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Latent Tuberculosis ◽  
Risk Groups ◽  
Interferon Γ ◽  
Public Hospitals ◽  
High Rate ◽  
Assay Result ◽  
Release Assay ◽  
Baseline Test ◽  
Tuberculosis Risk

Background.Surveillance for latent tuberculosis in high-risk groups such as healthcare workers is limited by the nonspecificity of the tuberculin skin test (TST) in BCG-vaccinated individuals. The Mycobacterium tuberculosis antigen-specific interferon-γ release assays (IGRAs) show promise for more accurate latent tuberculosis detection in such groups.Objective.To compare the utility of an IGRA, the T-SPOT.TB assay, with that of the TST in healthcare workers with a high rate of BCG vaccination.Methods.Two hundred seven medical students from 2 consecutive cohorts underwent the T-SPOT.TB test and the TST in their final year of study. Subjects with negative baseline test results underwent repeat testing after working for 1 year as junior physicians in Singapore's public hospitals.Results.The baseline TST result was an induration 10 mm or greater in diameter in 177 of the 205 students who returned to have their TST results evaluated (86.3%), while the baseline T-SPOT.TB assay result was positive in 9 (4.3%) of the students. Repeat T-SPOT.TB testing in 182 baseline-negative subjects showed conversion in 9 (4.9%). A repeat TST in 18 subjects with baseline-negative TST results did not reveal any TST result conversion.Conclusions.The high rate of positive baseline TST results in our BCG-vaccinated healthcare workers renders the TST unsuitable as a surveillance tool in this tuberculosis risk group. Use of an IGRA has enabled the detection and treatment of latent tuberculosis in this group. Our T-SPOT.TB conversion rate highlights the need for greater tuberculosis awareness and improved infection control practices in our healthcare institutions.

Utility of an Interferon-γ Release Assay for Latent Tuberculosis Diagnosis in a Case of Bullous Pemphigoid

2009 ◽  
Vol 13 (5) ◽  
pp. 280-282 ◽  
Author(s):  
Alfred Goodfellow ◽  
Douglas N. Keeling ◽  
Robert C. Hayes ◽  
Duncan Webster
Keyword(s):  
Tuberculin Skin Test ◽  
Bullous Pemphigoid ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Cutaneous Disease ◽  
Release Assay

Background: With increasing use of immunosuppressive therapy, including tumor necrosis factor a inhibitors, there is concern about infectious complications, including reactivation of latent Mycobacterium tuberculosis infection. Routine testing prior to administration of systemic immunosuppression includes the tuberculin skin test, which lacks sensitivity and specificity and may be difficult to interpret in the presence of extensive cutaneous disease. Treatment of individuals with latent tuberculosis infection is recommended when immunosuppressive medications are to be employed. Observations: We report a case in which a diagnosis of latent tuberculosis infection in a patient with extensive bullous pemphigoid was clarified by the use of an interferon-γ release assay after equivocal tuberculin skin test results. Conclusion: Interferon-γ release assays are useful adjuncts to the tuberculin skin test in the diagnosis of latent tuberculosis infection in the setting of extensive cutaneous disease.

Serial interferon-γ release assay in children with latent tuberculosis infection and children with tuberculosis

2011 ◽  
Vol 47 (4) ◽  
pp. 401-408 ◽  
Author(s):  
Nataųa Nenadić ◽  
Branka Kristić Kirin ◽  
Ivka Zoričić Letoja ◽  
Davor Plavec ◽  
Renata Zrinski Topić ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Release Assay

Rate of Latent Tuberculosis Infection Detected by Occupational Health Screening of Nurses New to a London Teaching Hospital

2009 ◽  
Vol 30 (6) ◽  
pp. 581-584 ◽  
Author(s):  
Priya Khanna ◽  
Vladyslav Nikolayevskyy ◽  
Fiona Warburton ◽  
Elek Dobson ◽  
Francis Drobniewski
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Interferon Γ ◽  
Tuberculosis Infection ◽  
Release Assay ◽  
Ifn Γ ◽  
Positive Results ◽  
Tuberculosis Prevalence

The prevalence of latent tuberculosis infection in a cohort of nurses new to a London hospital was 7.6% (13 of 171), using an interferon-γ(IFN-γ) release assay, and 16.2% (24 of 148), using the tuberculin skin test. On multivariate analysis, birth in a country with tuberculosis prevalence of more than 40 cases per 100,000 population was associated with positive results of both the IFN-γ release assay and the tuberculin skin test.

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