scholarly journals POS0422 PANNICULITIS AS A MANIFESTATION OF AN AUTOIMMUNE/AUTOINFLAMMATORY DISEASE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 440.2-440
Author(s):  
O. Egorova ◽  
A. Datsina ◽  
A. Potapova
Keyword(s):  
Lupus Erythematosus ◽  
Subcutaneous Fat ◽  
Breast Implants ◽  
Lower Limbs ◽  
Immunological Parameters ◽  
Myasthenic Syndrome ◽  
Asia Syndrome ◽  
Sjögren’S Disease ◽  
Subcutaneous Fat Tissue ◽  
Mesh Hernioplasty

Background:ASIA syndrome or Schonfeld syndrome is an autoimmune/inflammatory condition induced by adjuvants in genetically susceptible individuals with the development of rheumatic diseases (RD), multiple sclerosis, sarcoidosis, and others.Objectives:to characterize the symptoms of panniculitis (Pn) associated with ASIA-syndromeMethods:Within 7 years, ASIA syndrome was diagnosed in 12 women, average age 37.2±7.4, with a referral diagnosis of “Erythema Nodosum” or “Panniculitis”. The duration of the disease was 16.7±3.9 months. In addition to general clinical study, the serum concentration of α-1 antitrypsin, amylase, lipase, ferritin, creatine phosphokinase (CPK), immunological parameters (ANP-Hep2, dsDNA, C3 and C4, CRP, ANCA, Scl-70, antibodies to cardiolipins G and M), computed tomography of the chest organs, pathomorphological and immunohistochemical examination of a biopsy specimen of skin with subcutaneous fat tissue (SFA) from the affected areas.Results:The development of ASIA syndrome was preceded by gluteoplasty using propantriol-1,2,3 (in 4 patients), liposuction (2), biorevitalization with hyaluronic acid (2) and endoprosthetics with breast implants (2), bone metal construction (1) and mesh hernioplasty (1). The clinical picture of Pn was characterized by generalized red-purple painful (VAS pain 55.8±17.3 mm) subcutaneous indurations on the upper limbs and trunk (in 100% of cases), face (16.6%) and lower limbs (33.3%), with ulceration and oily fluid leakage (58.6%). The saucer symptom was recorded in 83.3% of the observed patients. In 66.6% of cases, fever and articular syndrome were observed, in 41.6% – myasthenic syndrome and lymphadenopathy, in 8.3% – xerophthalmia, keratoconjunctivitis dry, xerostomia and recurrent parotitis. In blood tests, leukopenia (up to 2.0x109/l) was identified in 33.3% of patients, a significant increase in the level of creatinine phosphakinase – in 16,6%, a two or more times increase in ESR and CRP – in 100%. All patients demonstrated immunological changes. The morphological picture of the skin and SFA in 75% of cases resembled lobular Pn, in 8.3% – tumor lymphocytes with the immunophenotype of cytotoxic T-lymphocytes: CD3+, CD8+ were detected. The results obtained allowed confirming RD in 8 patients: systemic lupus erythematosus and idiopathic lobular panniculitis in 2 patients (respectively) and 1 in dermatomyositis, systemic scleroderma of Sjogren’s disease, mixed connective tissue disease. One case was diagnosed with sarcoidosis and T-cell lymphoma. In 2 patients after the liposuction procedure the course of Pn was reversible.Conclusion:Diagnosis of Pn associated with ASIA syndrome is a complex task that requires a multidisciplinary approach to verify the diagnosis and treatment tactics.Disclosure of Interests:None declared

Lupus mastitis

2021 ◽  
Author(s):  
N. WILLERS ◽  
P. BERTELOOT ◽  
I. WITTEVRONGHEL ◽  
G. JACOMEN ◽  
V. SCHELFHOUT ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Inflammatory Process ◽  
Breast Lesion ◽  
Cell Lymphoma ◽  
Subcutaneous Fat ◽  
Fat Tissue ◽  
Lupus Panniculitis ◽  
Immune Mediated ◽  
History Of ◽  
Subcutaneous Fat Tissue

Lupus mastitis Systemic lupus erythematosus (SLE) infrequently presents itself as lupus panniculitis. In lupus panniculitis the subcutaneous fat tissue is involved in the inflammatory process. Lupus mastitis is again a rare variant of lupus panniculitis, probably caused by an immune-mediated inflammatory process. In literature on the topic we can find 30 cases of lupus mastitis in men and women. Lupus mastitis may present like a breast lesion suspected to be malignant, clinically and radiologically. In the differential diagnosis we consider inflammatory breast cancer, subcutaneous panniculitis-like T-cell lymphoma (SPTL) and diabetes mastopathy. With a medical history of SLE and signs of inflammation of the skin above the lesion however, a diagnosis of lupus mastopathy is more presumable. Medical treatment seems more indicated in lupus mastitis, because delayed healing after surgical procedures is often reported. Even though methylprednisolone and chloroquine give clinical improvement, they need to be repeated often because of a high risk of relapse.

scholarly journals A report of chronic intestinal pseudo-obstruction related to systemic lupus erythematosus

Open Medicine ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 562-564 ◽  
Author(s):  
Ruiqiang Wang ◽  
Bowen Zheng ◽  
Biyue Wang ◽  
Pupu Ma ◽  
Fengmei Chen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Clinical Symptoms ◽  
Gastrointestinal Disorder ◽  
Lower Limbs ◽  
Class Iii ◽  
Systemic Lupus ◽  
Intravenous Corticosteroid ◽  
Clinical Presentations ◽  
Intestinal Pseudo Obstruction

AbstractChronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Reports about reduplicated CIPO as a complication of SLE is infrequent. A 49-year-old female suffering from clinical symptoms of ileus has been hospitalized 3 times over 1 year. Her examination results showed no observation of mechanical obstruction. In August 2017, she came to the nephrology department due to edema in both lower limbs along with symptoms of ileus. After thorough examination, she was diagnosed with secondary CIPO related to SLE. Results of renal biopsy confirmed to be lupus nephritis (Class III-(A) + V). The symptoms of ileus are gradually improved after treatment of full-dose intravenous corticosteroid for 5 days.

Hormonal function after ovarian transposition to the abdominal subcutaneous fat tissue

2006 ◽  
Vol 16 (1) ◽  
pp. 121-124 ◽  
Author(s):  
S. NAGAO ◽  
K. FUJIWARA ◽  
H. ISHIKAWA ◽  
T. ODA ◽  
K. TANAKA ◽  
...  
Keyword(s):  
Subcutaneous Fat ◽  
Fat Tissue ◽  
Ovarian Transposition ◽  
Hormonal Function ◽  
Subcutaneous Fat Tissue

Facial Lipoatrophy following Systemic Lupus Erythematosus

2003 ◽  
Vol 7 (3) ◽  
pp. 232-235
Author(s):  
Audrey Dupéré ◽  
Yves Poulin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Subcutaneous Fat ◽  
Systemic Lupus ◽  
Rapid Loss ◽  
Cutaneous Lesions ◽  
Partial Lipodystrophy ◽  
C3 Nephritic Factor ◽  
Facial Lipoatrophy ◽  
Immunological Factors

Background: Acquired partial lipodystrophy is a rare disorder. An association with systemic lupus erythematosus has been reported. In these cases, an immunologic basis is suggested by the presence of C3 nephritic factor and hypocomplementemia. Objective: The following report presents the case of a woman who developed a rapid loss of facial subcutaneous fat a few months after complete spontaneous resolution of cutaneous lesions of lupus. Conclusion: Absence of C3NeF in this case suggests that other immunological factors may be involved in the pathogenesis.

scholarly journals The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women

2019 ◽  
pp. 1
Author(s):  
Aslihan Dilara Demir ◽  
Pervin Karli ◽  
Durmus Ayan
Keyword(s):  
Pregnant Women ◽  
Subcutaneous Fat ◽  
Metabolic Parameters ◽  
Strong Positive Correlation ◽  
Fat Tissue ◽  
Tissue Thickness ◽  
Positive Correlation ◽  
Endocrine Organs ◽  
The Relationship ◽  
Subcutaneous Fat Tissue

<p><strong>Objective:</strong> Obesity is a very common and important health problem and it has become widespread all over the world. Fat tissue is one of the major endocrine organs. Subcutaneous adipose tissue is associated with many diseases such as coronary artery disease, metabolic syndrome, diabetes, impaired lipid profile. Pregnancy is a special condition with metabolic changes involving all systems. We aimed to investigate the relationship and correlation between abdominal fat and HbA1c because of the specific metabolic conditions in pregnancy.</p><p><strong>Study Design:</strong> This is a retrospective study. Ninety-nine (n=99) pregnant women between the ages of 20 and 40 were included in the present study. They have not any other chronic diseases. Ultrasonography was performed between 16.-28. weeks. Abdominal subcutaneous fat tissue was measured during 16-28 weeks of pregnancy. Routine biochemical parameters and HbA1c were evaluated.</p><p><strong>Results:</strong> Subcutaneous fat tissue had a positive correlation with metabolic parameters such as weight and BMI, and a negative correlation with vitamin D level. There is a positive strong correlation with HbA1c level. There was not any correlation between HbA1c and metabolic parameters like triglyceride, LDL, HDL, and cholesterol.</p><p><strong>Conclusion:</strong> There was a strong positive correlation between abdominal subcutaneous fat tissue thickness and HbA1c. However, we didn’t find any correlation between infant weight and metabolic parameters.</p>

scholarly journals The quality of pork ham - tissue yield depending on individual factors

2018 ◽  
Vol 34 (4) ◽  
pp. 395-404
Author(s):  
Cedomir Radovic ◽  
Marija Gogic ◽  
Nenad Parunovic ◽  
Dragan Radojkovic ◽  
Radomir Savic ◽  
...  
Keyword(s):  
Muscle Tissue ◽  
Subcutaneous Fat ◽  
Fatty Tissue ◽  
Fat Tissue ◽  
Large White ◽  
Mean Values ◽  
Four Seasons ◽  
The Mean ◽  
Subcutaneous Fat Tissue ◽  
Sire Breed

The study included the progeny of three boar-sires breeds (SL - Swedish Landrace; LW - Large White and P - Pietrain). A total of 201 progeny of both sexes (93 female and 108 male castrated animals), originating from 16 boar-sires, were tested. The study included the progeny of 10 SL boar-sires (sires nuRWer: 1, 2, 3, 7, 8, 9, 15, 16, 17 and 18), progeny of 3 LW sires (sires nuRWer: 4, 5 and 6) and 3 P boar-sires (sires nuRWer 14, 19 and 20), born in four seasons (winter, spring, summer and autumn). Studies have shown that, with an mean weight of a warm carcass side of 81.20 kg, the highest mean values for ham weight (RW; 10.456 kg), mass of intermuscular fatty tissue (RINT; 0.477 kg), ham bone (RB; 0.837 kg) and muscle tissue RMT, 7,939 kg) have progeny of the sires of Pietrain breed (P) compared to SL and LW sires. In comparison to animals sired by SL and LW boars, the progeny of P sires had less skin and subcutaneous fat tissue (RSFT) by 30 and 549 grams. Studies have shown that we have progeny of sires 7 and 9 of SL breed which have the lowest LSMean values for the yield of skin and subcutaneous fat tissue (869 and 876 g), which is below the mean for breed by 364 and 357 g. In addition, when it comes to intermuscular fatty tissue, the lowest established value was recorded in the progeny of sire no. 8 of SL breed (182 g), which is by 220 g less than the general mean and by 132 g below the mean of the sire breed. The animals originating from sires n. 19 and 20 showed the highest weight of muscle tissue (RMT) (8.489 and 8.118 kg) in the ham, which is by 2.853 and 2.482 kg more meat compared to the progeny of sire no. 5 of LW breed. The total weight of the ham and the ham muscle yield were influenced by (P <0.01 and P <0.001) sire breed, sires within the breed, gender and season of birth. A very significant (P <0.001) influence of the weight of warm carcass sides on the ham weight and tissue yield was determined.

scholarly journals Pericarditis in contemporary therapeutic clinic: nosological spectrum, approaches to diagnosis and treatment

2020 ◽  
Vol 92 (12) ◽  
pp. 10-18
Author(s):  
O. V. Blagova ◽  
A. V. Nedostup ◽  
V. P. Sedov ◽  
E. A. Kogan ◽  
I. N. Alijeva ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Combined Treatment ◽  
Subcutaneous Fat ◽  
Lymph Node Biopsy ◽  
Diagnosis And Treatment ◽  
Al Amyloidosis ◽  
Leading Role ◽  
Line Of Therapy ◽  
Special Examination ◽  
Thoracoscopic Biopsy

Aim.To analyze the register of pericarditis in a therapeutic clinic, to evaluate their nosological spectrum, to optimize approaches to diagnosis and treatment. Materials and methods.For the period 20072018, the register includes 76 patients with the diagnosis of pericarditis (average age 53.115.7 years, 2085 years, 46 female). Patients with hydropericardium were not included in the register. Diagnostic puncture of pericardium was carried out in 5 patients, pleural puncture in 11 patients. Morphological diagnostics included endomyocardial/ intraoperative biopsy of myocardium (n=4/2), thoracoscopic/intraoperative biopsy of pericardium (n=1/6), pleural puncture (n=5), transbronchial (n=1), thoracoscopic biopsy of intrathoracic lymph nodes (n=2), lung (n=1), supraclavicular lymph node biopsy (n=1), salivary gland (n=1), subcutaneous fat and rectum biopsy per amyloid (n=6/1). The genome of cardiotropic viruses, level of anti-heart antibodies, C-reactive protein, antinuclear factor, rheumatoid factor (antibodies to cyclic citrullinized peptide), antibodies to neutrophil cytoplasm were determined, extractable nuclear antigens (ENA), protein immunoelectrophoresis, diaskin test, computed tomography of lungs and heart, cardiac magnetic resonance imaging, oncologic search. Results.The following forms of pericarditis were verified: tuberculosis (14%, including in combination with hypertrophic cardiomyopathy HCM), acute / chronic viral (8%) and infectious immune (38%), including perimyocarditis in 77%, pericarditis associated with mediastinum lymphoma/sarcoma (4%), sarcoidosis (3%), diffuse diseases of connective tissue and vasculitis (systemic lupus erythematosus, rheumatoid arthritis, diseases of Horton, Takayasu, Shegren, Wegener, 12%), leukoclastic vasculitis, Loefflers endomyocarditis, AL-amyloidosis, thrombotic microangiopathy (1% each), HCM (8%), coronary heart disease (constriction after repeated punctures and suppuration; postinfection and immune, 4%), after radiofrequency catheter ablation and valve prosthetics (2%). Tuberculosis was the main causes of constrictive pericarditis (36%). Treatment included steroids (n=39), also in combination with cytostatics (n=12), anti-tuberculosis drugs (n=9), acyclovir/ganclovir (n=14), hydroxychloroquine (n=23), colchicine (n=13), non-steroidal anti-inflammatory drugs (n=21), L-tyroxine (n=5), chemotherapy (n=1). In 36 patients different types of therapy were combined. Treatment results observed in 55 patients. Excellent and stable results were achieved in 82% of them. Pericardiectomy/pericardial resection was successfully performed in 8 patients. Lethality was 13.2% (10 patients) with an average follow-up 9 [2; 29.5] months (up to 10 years). Causes of death were chronic heart failure, surgery for HCM, pulmonary embolism, tumor. Conclusion.During a special examination, the nature of pericarditis was established in 97% of patients. Morphological and cytological diagnostics methods play the leading role. Tuberculosis pericarditis, infectious-immune and pericarditis in systemic diseases prevailed. Infectious immune pericarditis is characterized by small and medium exudate without restriction and accompanying myocarditis. Steroids remain the first line of therapy in most cases. Hydroxychloroquine as well as colchicine can be successfully used in moderate / low activity of immune pericarditis and as a long-term maintenance therapy after steroid stop.

Genetic explanations 2: adaptations in body size, shape, and composition

2019 ◽  
pp. 58-74
Author(s):  
Raj S. Bhopal
Keyword(s):  
South Asians ◽  
Subcutaneous Fat ◽  
Fat Distribution ◽  
Lower Limbs ◽  
Skeletal Structure ◽  
Central Adiposity ◽  
Evolutionary Forces ◽  
Fat Deposits ◽  
Central Fat ◽  
Small Muscle

Central body fat has been shown to be metabolically harmful while peripheral fat is neutral or even beneficial. The adipose tissue (compartment) overflow and the variable disease selection hypotheses aim to explain why South Asians tend to central adiposity. The former proposes it results from a small superficial subcutaneous fat compartment especially in the lower limbs, so excess energy is deposited as fat in central compartments. The evolutionary forces for this are presumed to be climatic. The latter proposes central fat deposits in South Asians are an evolutionary adaptation to combat gastrointestinal infections. South Asians’ also have small muscle mass, and small hips, for which there are no well-defined hypotheses. The small size at birth of South Asians may be relevant to all these observations. These differences in fat distribution, muscle and skeletal structure could explain a tendency to central (apple-shaped) obesity than generalized or peripheral obesity (pear-shaped).

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