1711 The Relationship between the First Episode of Wheezing and Matrix Metalloproteinases-9 and -2 and Timp-1 Levels in Preterm Infants

Abstract Peritonitis is a critical complication of peritoneal dialysis (PD). Investigators have reported the risk of peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) versus automated peritoneal dialysis (APD), but the available evidence is predominantly based on observational studies which failed to report on the connection type. Our understanding of the relationship between peritonitis risk and PD modality thus remained insufficient. We studied 285 participants who began PD treatment between 1997 and 2014 at three hospitals in Nara Prefecture in Japan. We matched 106 APD patients with 106 CAPD patients based on their propensity scores. The primary outcome was time to first episode of peritonitis within 3 years after PD commencement. In total, PD peritonitis occurred in 64 patients during the study period. Patients initiated on APD had a lower risk of peritonitis than did those initiated on CAPD in both the unadjusted and adjusted models. The hazard ratio (HR) and 95% confidence interval (CI) for the primary endpoint were 0.30 (0.17–0.53) in the fully adjusted model including connection type. In the matched cohort, APD patients had a significantly lower risk of peritonitis than did CAPD patients (log-rank: p < 0.001, HR 0.32, 95% CI 0.16–0.59). The weighting-adjusted analysis of the inverse probability of treatment yielded a similar result (HR 0.35, 95% CI 0.18–0.67). In conclusion, patients initiated on APD at PD commencement had a reduced risk of peritonitis compared with those initiated on CAPD, suggesting APD may be preferable for prevention of peritonitis among PD patients.

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MiR‐132 down‐regulates high glucose‐induced β‐dystroglycan degradation through Matrix Metalloproteinases‐9 up‐regulation in primary neurons

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.16669 ◽

2021 ◽

Author(s):

Yunxiao Dou ◽

Yan Tan ◽

Tongya Yu ◽

Xiaoye Ma ◽

Yuchen Zhou ◽

...

Keyword(s):

Matrix Metalloproteinases ◽

High Glucose ◽

Primary Neurons ◽

Matrix Metalloproteinases 9

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Exploring the relationship between recency and frequency of cannabis use and diminished expression and apathy as two dimensions of negative symptoms in first episode psychosis. A one-year follow-up study

Schizophrenia Research ◽

10.1016/j.schres.2021.08.004 ◽

2021 ◽

Vol 236 ◽

pp. 89-96

Author(s):

Henrik Myhre Ihler ◽

Trine Vik Lagerberg ◽

Siv Hege Lyngstad ◽

Ingrid Melle ◽

Kristin Lie Romm

Keyword(s):

Negative Symptoms ◽

First Episode Psychosis ◽

Two Dimensions ◽

Cannabis Use ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis ◽

One Year ◽

The Relationship

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The relationship between overweight and thyroid function in first-episode, untreated Chinese patients with major depressive disorder with different ages of onset

Journal of Affective Disorders ◽

10.1016/j.jad.2021.07.110 ◽

2021 ◽

Author(s):

Hehua Li ◽

Yuanyuan Huang ◽

Xiaocui Zang ◽

Zhimin Zhu ◽

Mingzhe Yang ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Thyroid Function ◽

Chinese Patients ◽

First Episode ◽

Major Depressive ◽

Different Ages ◽

The Relationship

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PERIODIC BREATHING AND APNEA IN PRETERM INFANTS. II. HYPOXIA AS A PRIMARY EVENT

PEDIATRICS ◽

10.1542/peds.50.2.219 ◽

1972 ◽

Vol 50 (2) ◽

pp. 219-228

Author(s):

Henrique Rigatto ◽

June P. Brady

Keyword(s):

Preterm Infants ◽

Oxygen Tension ◽

Minute Ventilation ◽

Arterial Oxygen Tension ◽

Blood Gases ◽

Periodic Breathing ◽

Capillary Blood ◽

Arterial Oxygen ◽

Primary Event ◽

The Relationship

We studied nine healthy preterm infants during the first 35 days of life to define the relationship between periodic breathing, apnea, and hypoxia. For this purpose we compared ventilation/apnea (V/A), minute ventilation, and alveolar and capillary blood gases during periodic breathing induced by hypoxia and during spontancous periodic breathing in room air. We induced periodic breathing by giving the baby in sequence 21, 19, 17, and 15% O2 to breathe for 5 minutes each, and also by giving 21, 15, and 21% O2. We measured ventilation with a nosepiece and a screen flowmeter. With a decrease in arterial oxygen tension, preterm infants (1) hypoventilated, (2) breathed periodically more frequently, and (3) showed a decrease in V/A due to an increase in the apneic interval. In one baby this led to apnea lasting 30 seconds. These findings support our hypothesis that preterm infants breathing periodically hypoventilate and suggest that hypoxia may be a primary event leading to periodic breathing and apnea.

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Breath-to-breath variability of exhaled CO2 as a marker of lung dysmaturity in infancy

Journal of Applied Physiology ◽

10.1152/japplphysiol.00372.2017 ◽

2017 ◽

Vol 123 (6) ◽

pp. 1563-1570 ◽

Cited By ~ 2

Author(s):

Sotirios Fouzas ◽

Ilias Theodorakopoulos ◽

Edgar Delgado-Eckert ◽

Philipp Latzin ◽

Urs Frey

Keyword(s):

Lung Disease ◽

Preterm Infants ◽

Chronic Lung Disease ◽

Tidal Breathing ◽

Term Infants ◽

Young Infants ◽

Postmenstrual Age ◽

Preterm Group ◽

Preterm Born ◽

The Relationship

The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable postmenstrual age but born at different stages of lung maturity, namely, in term-born infants ( n = 128), preterm-born infants without chronic lung disease of infancy (CLDI; n = 53), and preterm infants with moderate/severe CLDI ( n = 87). Exhaled CO2 volume (VE,CO2) and concentration (FE,CO2) were determined by volumetric capnography, whereas their variance was assessed by linear and nonlinear variability metrics. The relationship between relative breath-to-breath change of VE,CO2 (ΔVE,CO2) and the corresponding change of tidal volume (ΔVT) was also analyzed. Nonlinear FE,CO2 variability was lower in CLDI compared with term and non-CLDI preterm group ( P < 0.001 for both comparisons). In CLDI infants, most of the VE,CO2 variability was attributed to the variability of VT ( r2 = 0.749), whereas in term and healthy preterm infants this relationship was weaker ( r2 = 0.507 and 0.630, respectively). The ΔVE,CO2 − ΔVT slope was less steep in the CLDI group (1.06 ± 0.07) compared with non-CLDI preterm (1.16 ± 0.07; P < 0.001) and term infants (1.20 ± 0.10; P < 0.001), suggesting that the more dysmature the infant lung, the less efficiently it eliminates CO2 under tidal breathing conditions. We conclude that the temporal variation of CO2 clearance may be related to the degree of lung dysmaturity in early infancy. NEW & NOTEWORTHY Young infants exhibit appreciable breath-to-breath CO2 variability that can be quantified by nonlinear variability metrics and may reflect the degree of lung dysmaturity. In infants with moderate/severe chronic lung disease of infancy (CLDI), the variability of the exhaled CO2 is mainly driven by the variability of breathing, whereas in term-born and healthy preterm infants this relationship is less strong. The slope of the relative CO2-to-volume change is less steep in CLDI infants, suggesting that dysmature lungs are less efficient in eliminating CO2 under tidal breathing conditions.

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O4.5. EXPLORING THE RELATIONSHIP BETWEEN SENSORY FILTERING AND COGNITION: RESULTS OF A LARGE COHORT OF ANTIPSYCHOTIC-NAïVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS

Schizophrenia Bulletin ◽

10.1093/schbul/sbz021.205 ◽

2019 ◽

Vol 45 (Supplement_2) ◽

pp. S170-S171

Author(s):

Caitlyn Kruiper ◽

Birgitte Fagerlund ◽

Mette Nielsen ◽

Signe During ◽

Bjorn Ebdrup ◽

...

Keyword(s):

Large Cohort ◽

First Episode ◽

First Episode Schizophrenia ◽

The Relationship

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Predictors of outcome in first-episode schizophrenia over the first 4 years of illness

Psychological Medicine ◽

10.1017/s003329170800336x ◽

2008 ◽

Vol 38 (8) ◽

pp. 1141-1146 ◽

Cited By ~ 26

Author(s):

P. Whitty ◽

M. Clarke ◽

O. McTigue ◽

S. Browne ◽

M. Kamali ◽

...

Keyword(s):

Negative Symptoms ◽

First Episode ◽

Global Assessment Of Functioning ◽

Methodological Issues ◽

Course Of Illness ◽

Dsm Iv ◽

First Episode Schizophrenia ◽

The Relationship ◽

Positive And Negative Symptoms

BackgroundThe outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.MethodWe conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables.ResultsThere were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=−3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=−2.77, p<0.01) significantly predicted a better outcome at follow-up.ConclusionsThe outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness.

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