PO-0442 Levels Of Cerebrospinal Fluid (csf) Beta-2-microglobulina (b2m) In Newborns With Posthemorrhagic Hydrocephalus (phh) And Omaya Reservoir (or)

Background ― Posthemorrhagic hydrocephalus in newborns with occlusion of cerebrospinal fluid leads to decompensation of cerebrospinal fluid dynamics. There is no single method that meets all the criteria for the effectiveness and safety of treatment. The study goal was to investigate the use of coronary translambdoid subarachnoid ventriculostomy (CTSV) and ventricular subarachnoid stenting (VSS) in the treatment of neonatal hydrocephalus. Material and Methods ― The analysis of the posthemorrhagic hydrocephalus treatment in 327 newborns for the period of 2000-2018 in Crimea. Two groups have been identified. In the Group 1, 184 children underwent standard treatment according to the ‘LVV protocol’ with lumbar and ventricular punctures with 20-22G needles, while with progression of hydrocephalus, with ventriculosubgaleal drainage and ventriculoperitoneal shunt. In 143 children with occlusion and ventricular block, the treatment complex included CTSV – RF Patent No. 2715535, and ventricular drainage by the ventricular subarachnoid stenting (VSS) – RF Patent No. 2721455. Results ― An increase in the treatment radicality under CTSV is achieved through the use of the cerebral needles of a larger diameter (14G) and puncture access zones, elimination of occlusion, while under VSS, restoration of intracranial circulation and absorption of cerebrospinal fluid is ensured by prolonged sanitation with a saline solution of cerebrospinal fluid spaces. A positive outcome with compensation for hydrocephalus was achieved in 75.4% of cases versus 28.2% under the conventional protocol (p<0.001). In other cases, the imbalance of production and absorption of cerebrospinal fluid remained, which required the integration of the VSS with the peritoneal segment of the shunt, without further replacement and reinstallation of the system. Conclusion ― Our results allow us to consider the effectiveness of CTSV and VSS inclusion in the contemporary algorithm for the treatment of decompensated posthemorrhagic hydrocephalus in newborns.

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Dopamine beta-hydroxylase and beta 2-microglobulin in cerebrospinal fluid: early markers in Parkinson’s disease?

New Vistas in Drug Research - Early Markers in Parkinson’s and Alzheimer’s Diseases ◽

10.1007/978-3-7091-9098-2_9 ◽

1990 ◽

pp. 71-78

Author(s):

T. Nagastu ◽

M. Mogi ◽

M. Harada ◽

K. Kojima

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cerebrospinal Fluid ◽

Dopamine Beta Hydroxylase ◽

Early Markers ◽

Beta 2 ◽

Beta 2 Microglobulin

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Preliminary Study on the Stability of Beta-2 Transferrin in Extracorporeal Cerebrospinal Fluid

Otolaryngology ◽

10.1177/0194599810390887 ◽

2010 ◽

Vol 144 (1) ◽

pp. 101-103 ◽

Cited By ~ 11

Author(s):

Benjamin S. Bleier ◽

Indranil Debnath ◽

Brendan P. O’Connell ◽

W. Alexander Vandergrift ◽

James N. Palmer ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Preliminary Study ◽

Beta 2 ◽

The Stability

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Immunofixation to Quantify β2-Transferrin in Cerebrospinal Fluid to Detect Leakage of Cerebrospinal Fluid from Skull Injury

Clinical Chemistry ◽

10.1093/clinchem/38.9.1909a ◽

1992 ◽

Vol 38 (9) ◽

pp. 1909-1912 ◽

Cited By ~ 3

Author(s):

D L Zaret ◽

N Morrison ◽

R Gulbranson ◽

D F Keren

Keyword(s):

Cerebrospinal Fluid ◽

High Resolution ◽

Motor Vehicle ◽

Motor Vehicle Accident ◽

Olfactory Groove ◽

Vehicle Accident ◽

Coomassie Blue ◽

Csf Leakage ◽

Beta 2 ◽

Accurate Quantification

Abstract beta 2-Transferrin, the desialated form of transferrin normally found only in cerebrospinal fluid (CSF) and aqueous and vitreous humor, is detected by high-resolution immunofixation (IFE). It is not normally found in nasal or aural fluids, saliva, tears, or serum. Detection in nasal fluid has been suggested to document CSF leakage into the nose after skull injury. We measured beta 2-transferrin in 48 samples of CSF. IFE of the CSF was performed on high-resolution agarose gels and stained with Coomassie Blue. beta 2-Transferrin was estimated by quantifying the total transferrin by rate nephelometry and then determining the percentage of transferrin in the beta 2 vs beta 1 region by densitometric scanning of the IFE pattern. We accurately quantified as little beta 2-transferrin as 2.5 mg/L in the CSF samples. The beta 2-transferrin fraction was clearly visible by IFE at concentrations less than 2.5 mg/L, but accurate quantification was difficult. In the samples assayed, the range of beta 2-transferrin was 4.6 +/- 1.9 mg/L. Use of this technique to examine rhinorrhea in a motor-vehicle-accident patient confirmed leakage of CSF into the nasal cavity through a vent in the left olfactory groove.

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Endoscopic CSF rhinorrhea closure: Our experience in 267 cases

Otolaryngology ◽

10.1016/j.otohns.2004.09.004 ◽

2005 ◽

Vol 132 (2) ◽

pp. 208-212 ◽

Cited By ~ 59

Author(s):

Milind V. Kirtane ◽

K. Gautham ◽

Shraddha R. Upadhyaya

Keyword(s):

Cerebrospinal Fluid ◽

Revision Surgery ◽

Fascia Lata ◽

Sinus Surgery ◽

Minimum Period ◽

Csf Rhinorrhea ◽

Cerebrospinal Fluid Rhinorrhea ◽

Endoscopic Closure ◽

Transnasal Endoscopic Approach ◽

Beta 2

OBJECTIVES: The advances in endoscopic sinus surgery have made it the procedure of choice for treatment of cerebrospinal fluid rhinorrhea (CSFR). To analyze the efficacy of endoscopic closure of CSFR was the objective of the present study. METHODS: We treated 267 patients with CSFR endo-scopically. Diagnosis was achieved with the help of CT with or without cisternography, MRI, beta-2 transferrin levels. Fascia lata and fat were used to plug the defects. The patients were followed up for a minimum period of 6 months. RESULTS: CSFR was successfully plugged in 258 patients. Nine patients required revision surgery. Six could be plugged successfully endoscopically and 2 patients by a neurosurgical approach. CONCLUSIONS: In our experience with 267 patients of endoscopically treated CSFR, the results of achieving the closure was 96.63% in the first instance and 98.88% after revision surgery. SIGNIFICANCE: The transnasal endoscopic approach has excellent results in the treatment of CSFR. We recommend it as the optimum surgical approach for both primary and revisional surgical management of CSFR.

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