scholarly journals Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis.

1984 ◽  
Vol 43 (3) ◽  
pp. 435-439 ◽  
Author(s):  
M M Steven ◽  
S E Lennie ◽  
R D Sturrock ◽  
C G Gemmell
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

scholarly journals Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Kyung-Ann Lee ◽  
Kyoung-Woon Kim ◽  
Bo-Mi Kim ◽  
Ji-Yeon Won ◽  
Hong Ki Min ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Osteoclast Differentiation ◽  
Joint Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tartrate Resistant Acid Phosphatase ◽  
Dependent Manner ◽  
Receptor Subunit ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

Abstract Background The inflammatory cascade in the rheumatoid arthritis (RA) synovium is modulated by a variety of cytokine and chemokine networks; however, the roles of IL-26, in RA pathogenesis, are poorly defined. Here, we investigated the functional role of interleukin-26 (IL)-26 in osteoclastogenesis in RA. Methods We analyzed levels of IL-20 receptor subunit A (IL-20RA), CD55, and receptor activator of nuclear factor kappaB (NF-κB) ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs) using confocal microscopy. Recombinant human IL-26-induced RANKL expression in RA-FLSs was examined using real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). Human peripheral blood monocytes were cultured with macrophage colony-stimulating factor (M-CSF) and IL-26, after which osteoclastogenesis was evaluated by counting the number of tartrate-resistant acid phosphatase-positive multinucleated cells. Additionally, osteoclastogenesis was evaluated by monocytes co-cultured with IL-26-prestimulated FLSs. Results The expression of IL-20RA in RA-FLSs was higher than that in osteoarthritis-FLSs. Additionally, in IL-26-pretreated RA-FLSs, the expression of IL-20RA (but not IL-10 receptor subunit B) and RANKL increased in a dose-dependent manner, with IL-26-induced RANKL expression reduced by IL-20RA knockdown. Moreover, IL-26-induced RANKL expression was significantly downregulated by inhibition of signal transducer and activator of transcription 1, mitogen-activated protein kinase, and NF-κB signaling. Furthermore, IL-26 promoted osteoclast differentiation from peripheral blood monocytes in the presence of low dose of RANKL, with IL-26 exerting an additive effect. Furthermore, co-culture of IL-26-pretreated RA-FLSs with peripheral blood monocytes also increased osteoclast differentiation in the absence of addition of RANKL. Conclusions IL-26 regulated osteoclastogenesis in RA through increased RANKL expression in FLSs and direct stimulation of osteoclast differentiation. These results suggest the IL-26/IL-20RA/RANKL axis as a potential therapeutic target for addressing RA-related joint damage.

scholarly journals Proteinase-activated receptor 2 expression on peripheral blood monocytes and T-cells in patients with rheumatoid arthritis

2016 ◽  
Vol 38 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Samia H. Kandel ◽  
Wafaa M. Radwan ◽  
Heba A. Esaily ◽  
Shimaa F. Al-mahmoudy
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral blood monocytes in patients with active rheumatoid arthritis

2013 ◽  
Vol 698 (1-3) ◽  
pp. 429-434 ◽  
Author(s):  
Jianlin Huang ◽  
Baozhao Xie ◽  
Qiuxia Li ◽  
Xujing Xie ◽  
Shangling Zhu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Active Rheumatoid Arthritis ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

A1.48 Enhanced expression of CD11c on non-classical CD16+peripheral blood monocytes in early rheumatoid arthritis

2014 ◽  
Vol 73 (Suppl 1) ◽  
pp. A20.2-A21 ◽  
Author(s):  
Olga Krystufkova ◽  
Herman Mann ◽  
Hana Hulejova ◽  
Ladislav Senolt ◽  
Jiri Vencovsky
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Enhanced Expression

scholarly journals PAR2expression in peripheral blood monocytes of patients with rheumatoid arthritis

2012 ◽  
Vol 71 (6) ◽  
pp. 1049-1054 ◽  
Author(s):  
A Crilly ◽  
E Burns ◽  
M B Nickdel ◽  
J C Lockhart ◽  
M E Perry ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes

TNF-α-elicited miR-29b potentiates resistance to apoptosis in peripheral blood monocytes from patients with rheumatoid arthritis

APOPTOSIS ◽  
2019 ◽  
Vol 24 (11-12) ◽  
pp. 892-904 ◽  
Author(s):  
Baodi Ren ◽  
Jiayu Liu ◽  
Kunyi Wu ◽  
Junli Zhang ◽  
Yanyan Lv ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Peripheral Blood ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Tnf Α

The Expression of Decoy Receptor 3 in Peripheral Blood Monocytes of Rheumatoid Arthritis Patient

2013 ◽  
Vol 709 ◽  
pp. 848-851
Author(s):  
Ke Xin Sun ◽  
Chun Hui Li ◽  
Yan Li ◽  
Su Hong Guo ◽  
Yi Ju Hou
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Patient ◽  
Peripheral Blood ◽  
Pathological Process ◽  
Mrna Levels ◽  
Healthy Controls ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Expression Levels ◽  
Decoy Receptor 3

To investigate DcR3 mRNA levels of peripheral blood monocytes in rheumatoid arthritis(RA)，and analyzes the correlation between the DcR3 Levels of Peripheral Blood and the Disease Activity in Rheumatoid Arthritis Patient. The expression levels of DcR3 mRNA in peripheral Blood monocytes of 82 RA patients and 53 healthy controls were detected by real-time polymerase chain reaction. The expression levels of DcR3 mRNA of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.05); The correlationships between DcR3 mRNA levels and active renal score (DAS28)show positive correlation. The expression levels of peripheral blood DcR3 does significant increase in RA active patients and it is closely related with the activity of the disease which suggesting that DcR3 migh involved in the pathological process.

Sign in / Sign up

Export Citation Format

Share Document