Pleural tuberculosis following lung cancer chemotherapy: a report of two cases proven pathologically by pleural biopsy

Backgrounds: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB, but a definite diagnosis is still a challenge. Pleural biopsy has historically been the gold standard procedure for the diagnosis of pleural tuberculosis. GenXpert® is a computerize test based in nucleic acid amplification tahat automatically detect MTB and rifampicin resistance. This study aimed to prove the correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. Methods: This study used an observational analytic design with a cross-sectional design conducted in Dr. Soetomo Hospital, Surabaya in March-June 2017. Statistic analysis was using chi square test and contingensi coofisient. The pleural GenXpert® was tested in 23 patients with pleural effusion and their biopsy speciments underwent histopathological analysis. Results: Histopathological findings of pleural biopsy was positive in 4 subjects and pleural fluid GenXpert® resulted positive in 6 subjects. There was significant correlation between pleural fluid GenXpert® and histopathological findings of specimen pleural biopsy in patients with pleural tuberculosis (P=0.040) with moderate strenght (P=0.014). Sensitivity and specificity of pleural fluid GenXpert® were 75.0% dan 84.2% respectively. Conclusions: There was significant correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. (J Respir Indo 2018; 38(1): 1-6)

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Unresectable Non-Small Cell Lung Cancer Chemotherapy with High-Dose Cisplatin and Etoposide

Oncology ◽

10.1159/000226035 ◽

1985 ◽

Vol 42 (4) ◽

pp. 224-228 ◽

Cited By ~ 3

Author(s):

Giorgio V. Scagliotti ◽

Donatella Lodico ◽

Felice Gozzelino ◽

Franco Bardessono ◽

Carlo Albera ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Chemotherapy ◽

Cell Lung Cancer ◽

Small Cell ◽

High Dose ◽

Small Cell Lung

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The Influence of Sex on Efficacy, Adverse Events, Quality of Life, and Delivery of Treatment in National Cancer Institute of Canada Clinical Trials Group Non-small Cell Lung Cancer Chemotherapy Trials

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3181d40a1b ◽

2010 ◽

Vol 5 (5) ◽

pp. 640-648 ◽

Cited By ~ 8

Author(s):

Paul Wheatley-Price ◽

Aurélie Le Maître ◽

Keyue Ding ◽

Natasha Leighl ◽

Vera Hirsh ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Clinical Trials ◽

Adverse Events ◽

Small Cell Lung Cancer ◽

Cancer Chemotherapy ◽

National Cancer Institute ◽

Small Cell ◽

Small Cell Lung

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Pharmacologic Aspects of Lung Cancer Chemotherapy

Clinics in Chest Medicine ◽

10.1016/s0272-5231(21)01119-9 ◽

1986 ◽

Vol 7 (3) ◽

pp. 505-513

Author(s):

David B. Beard ◽

Charles M. Haskell

Keyword(s):

Lung Cancer ◽

Cancer Chemotherapy

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Cisplatin and Pemetrexed for Lung Cancer and Pleural Mesothelioma

Hospital Pharmacy ◽

10.1310/hpj4310-800 ◽

2008 ◽

Vol 43 (10) ◽

pp. 800-805

Author(s):

Dominic A. Solimando ◽

Kajal Patel ◽

J. Aubrey Waddell

Keyword(s):

Lung Cancer ◽

Antineoplastic Therapy ◽

Cancer Chemotherapy ◽

Pleural Mesothelioma ◽

Malignant Diseases ◽

Toxic Agents

The complexity of cancer chemotherapy requires that pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy and the agents, both commercially available and investigational, used to treat malignant diseases.

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