Metastatic MSSA infection of the spine and extremities

Few studies have examined the association between methicillin-susceptible Staphylococcus aureus (MSSA) infection and accessory gene regulator ( agr ) functionality. We evaluated the association between agr dysfunction and mortality in patients with MSSA bacteremia.

Download Full-text

Treatment of Non - tuberculous Infection of the Spine

The Journal of the Korean Orthopaedic Association ◽

10.4055/jkoa.1984.19.3.472 ◽

1984 ◽

Vol 19 (3) ◽

pp. 472 ◽

Cited By ~ 1

Author(s):

Han Koo Lee ◽

In Ho Choi

Keyword(s):

Tuberculous Infection ◽

Infection Of The Spine

Download Full-text

Nontuberculous Infection of the Spine

Proceedings of the Royal Society of Medicine ◽

10.1177/003591577707000313 ◽

1977 ◽

Vol 70 (3) ◽

pp. 176-181 ◽

Cited By ~ 1

Author(s):

J B Kersley

Keyword(s):

Infection Of The Spine

Download Full-text

The follow-up of patients with postoperative infection of the spine

European Journal of Orthopaedic Surgery & Traumatology ◽

10.1007/s00590-013-1243-9 ◽

2013 ◽

Vol 23 (S1) ◽

pp. 29-34 ◽

Cited By ~ 11

Author(s):

C. Barrey ◽

O. Launay ◽

E. Freitas ◽

F. Michel ◽

F. Laurent ◽

...

Keyword(s):

Postoperative Infection ◽

Infection Of The Spine

Download Full-text

Positive nasal Staphylococcus aureus polymerase chain reaction assay is not sensitive in predicting concurrent or subsequent Staphylococcus aureus infection in critically ill patients

Anaesthesia and Intensive Care ◽

10.1177/0310057x20911925 ◽

2020 ◽

Vol 48 (3) ◽

pp. 196-202

Author(s):

Kalai C Kanagasingham ◽

Kwok M Ho ◽

J Owen Robinson

Keyword(s):

Staphylococcus Aureus ◽

Polymerase Chain Reaction ◽

Critically Ill ◽

Sensitivity And Specificity ◽

Critically Ill Patients ◽

High Specificity ◽

Chain Reaction ◽

Pcr Assay ◽

Polymerase Chain ◽

Mssa Infection

Staphylococcal infection is associated with significant morbidity and mortality in critically ill patients. Using data from 16,681 patients who had a nasal Staphylococcus aureus polymerase chain reaction (PCR) assay on admission to the intensive care unit (ICU) of Royal Perth Hospital between March 2006 and September 2016, this retrospective cohort study assessed whether nasal S. aureus colonisation on admission to an ICU was predictive of concurrent or subsequent S. aureus infections. Culture-proven S. aureus infections were identified using the hospital microbiology database. Of the 16,681 patients included, 565 (3.4%) had a positive methicillin-resistant S. aureus (MRSA) assay, 146 (0.9%) had a positive methicillin-sensitive S. aureus (MSSA) assay and eight (0.05%) had both positive MRSA and MSSA assays. Of those 565 patients with a positive MRSA PCR assay, 79 (13.8%) had concurrent or subsequent MRSA infections. Of those 146 patients with a positive MSSA PCR assay, only 5 (3.4%) had MSSA infection. The sensitivity and specificity for the MRSA PCR assay in predicting concurrent or subsequent MRSA infection were 72.7% (95% confidence intervals (CI) 63.4%–80.8%) and 97.0% (95% CI 96.8%–97.3%), respectively. The sensitivity and specificity for the MSSA PCR assay in predicting concurrent or subsequent MSSA infection were 3.3% (95% CI 1.1%–7.6%) and 99.1% (95% CI 98.9%–99.2%), respectively. Both nasal MRSA and MSSA PCR assays had a high specificity and negative predictive value in predicting MRSA and MSSA infections, respectively, suggesting that in centres without endemic S. aureus infections, a negative nasal MRSA or MSSA PCR assay may be useful to reduce unnecessary empirical antibiotic therapy against S. aureus.

Download Full-text

Epidemiology of Methicillin-SusceptibleStaphylococcus aureusin a Neonatology Ward

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2015.184 ◽

2015 ◽

Vol 36 (11) ◽

pp. 1305-1312 ◽

Cited By ~ 15

Author(s):

Yvonne Achermann ◽

Kati Seidl ◽

Stefan P. Kuster ◽

Nadja Leimer ◽

Nina Durisch ◽

...

Keyword(s):

Tertiary Care ◽

Sequence Type ◽

University Hospital ◽

Infection Rates ◽

Group Iii ◽

Infection Surveillance ◽

Hospital Acquired ◽

Neonatal Ward ◽

Mssa Infection ◽

Hospital Transmission

OBJECTIVEIn-hospital transmission of methicillin-susceptibleStaphylococcus aureus(MSSA) among neonates remains enigmatic. We describe the epidemiology of MSSA colonization and infection in a 30-bed neonatal ward.DESIGNMultimodal outbreak investigationSETTINGA public 800-bed tertiary care university hospital in SwitzerlandMETHODSInvestigations in 2012–2013, triggered by a MSSA infection cluster, included prospective MSSA infection surveillance, microbiologic screening of neonates and environment, onsite observations, and a prospective cohort study. MSSA isolates were characterized by pulsed-field gel electrophoresis (PFGE) and selected isolates were examined for multilocus sequence type (MLST) and virulence factors.RESULTSAmong 726 in 2012, 30 (4.1%) patients suffered from MSSA infections including 8 (1.1%) with bacteremia. Among 655 admissions in 2013, 13 (2.0%) suffered from MSSA infections including 2 (0.3%) with bacteremia. Among 177 neonates screened forS. aureuscarriage, overall 77 (44%) tested positive. A predominant PFGE-1-ST30 strain was identified in 6 of 30 infected neonates (20%) and 30 of 77 colonized neonates (39%). This persistent clone waspvl-negative,tst-positive and belonged toagrgroup III. We found no environmental point source. MSSA carriage was associated with central vascular catheter use but not with a particular midwife, nurse, physician, or isolette. Observed healthcare worker behavior may have propagated transmission via hands and fomites. Despite multimodal interventions, clonal transmission and colonization continued and another clone, PFGE-6-ST5, became predominant.CONCLUSIONSHospital-acquired MSSA clones represent a high proportion of MSSA colonization but not MSSA infections in neonate inpatients. In contrast to persisting MSSA, transmission infection rates decreased concurrently with interventions. It remains to be established whether eradication of hospital-acquired MSSA strains would reduce infection rates further.Infect. Control Hosp. Epidemiol.2015;36(11):1305–1312

Download Full-text