scholarly journals Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants

2019 ◽  
Vol 12 (3) ◽  
pp. e227050 ◽  
Author(s):  
Bárbara Ribeiro ◽  
Raquel Silva ◽  
Renata Dias ◽  
Vanda Patrício
Keyword(s):  
Uterine Cervix ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Pathological Finding ◽  
Sarcomatous Component ◽  
Rare Tumour ◽  
Distant Disease ◽  
Mesonephric Duct ◽  
Mullerian Ducts ◽  
Mesonephric Carcinoma

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. We describe a case of a 64-year-old woman, presenting with vaginal bleeding and a cervical lesion reported as a sarcoma of endometrial stroma in the first biopsy. After exclusion of distant disease, she was submitted to radical surgery and the final histopathological examination showed a carcinosarcoma of the cervix with mesonephric origin.

scholarly journals Melanosis of the Uterine Cervix: A Rare Case Report

2021 ◽  
Author(s):  
Nikhil Sanjay Deshpande ◽  
Aditi Mittal ◽  
Anil B Munemane ◽  
Ravindra Raosaheb Karle
Keyword(s):  
Uterine Cervix ◽  
Histopathological Examination ◽  
Basal Layer ◽  
Pathological Finding ◽  
Final Diagnosis ◽  
Pathological Examination ◽  
Macular Lesion ◽  
Melanocytic Lesions ◽  
Rare Case Report ◽  
S 100

Cervical melanosis is a rare entity in the spectrum of melanocytic lesions of uterine cervix. Melanosis is defined as presence of melanocytes in the basal layer of squamous epithelium causing hyperpigmentation. Authors here by report a case of 57-year-old female who underwent vaginal hysterectomy for third degree utero-vaginal prolapse, showed an incidental gross pathological finding of brownish macular lesion. Histopathological examination showed hyperpigmentation of basal layer without increase in melanocytes. On immunohistochemical examination, basal melanocytes were highlighted by S-100 and HMB 45 immunostains. Thus final diagnosis of cervical melanosis was made. Clinical differentials of cervical pigmented melanocytic lesions include cervical melanomas, blue nevi, congenital or traumatic lesions and melanosis, hence vigilant clinical, gross pathological examination and biopsy is warranted.

scholarly journals Primary Malignant Melanoma of the Uterine Cervix Treated with Ultraradical Surgery: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Luz Calderón-Salazar ◽  
David Cantú de Leon ◽  
Delia Perez Montiel ◽  
Erika Almogabar-Villagrán ◽  
Verónica Villavicencio ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
World Literature ◽  
Standard Treatment ◽  
Pelvic Exenteration ◽  
Radical Surgery ◽  
Case Reports ◽  
Primary Malignant Melanoma ◽  
Optimal Management ◽  
Distant Disease

Primary melanomas of the uterine cervix are rare tumors with no more than 60 cases reported in the world literature. Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. Our aim was to present the case of a 34-year-old woman with a primary malignant melanoma in the uterine cervix with affectation of the posterior face of the vagina without metastasis. Total infraelevator pelvic exenteration and adjuvant radiotherapy was performed. The patient was under surveillance for 8 years of followup without evidence of local or distant disease. The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients. Notwithstanding this, survival is very short when patients are treated in this manner. Based on our results and on those reported in the literature, we propose initial treatment with total pelvic exenteration as optimal management for this neoplasia in its initial form.

scholarly journals Female Adnexal Tumour of Wolffian Origin: A Rare Case Report

2021 ◽  
Author(s):  
Soumit Dey ◽  
Pritam Ray ◽  
Debasish Bhattacharya ◽  
Mrinal Kanti Chaudhuri ◽  
Subir Kumar Dutta
Keyword(s):  
Fallopian Tube ◽  
Rare Case ◽  
Histopathological Examination ◽  
Broad Ligament ◽  
Histopathological Diagnosis ◽  
Rare Tumour ◽  
Rare Case Report ◽  
Mesonephric Duct ◽  
Cellular Pleomorphism ◽  
Adnexal Tumour

Female Adnexal Tumour of Wolffian Origin (FATWO) is a rare tumour occurring in adnexal region, arising from the remnants of the mesonephric duct, in places like the broad ligament, fallopian tube, ovarian hilum, peritoneum. Here the authors have reported a case of FATWO in a 47-year-old woman occurring in the wall of fallopian tube and confirmed with immunohistochemistry. Most of these tumours behave in a benign fashion but certain histological features like hypercellularity, cellular pleomorphism and nuclear atypia cause significant confusion in histopathological diagnosis. Multiple differential diagnoses were considered. After careful histopathological examination and thorough investigation with multiple immunohistochemical stains, the diagnosis was ultimately established.

scholarly journals Gartner’s Duct Cyst of the Vagina: A Case Report

2020 ◽  
Vol 58 (227) ◽  
Author(s):  
Baburam Dixit ◽  
Mohan Chandra Regmi
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Pelvic Organ ◽  
Pelvic Examination ◽  
Unique Case ◽  
Duct Cyst ◽  
Mesonephric Duct ◽  
Mullerian Ducts ◽  
Female Genital ◽  
Male Genital

Paramesonephric duct or Mullerian ducts forms female genital organs whereas mesonephric ductforms male genital organs. The remnant of the mesonephric duct or Wolffian duct in femalessometimes forms a mesonephric cyst or Gartner’s duct cyst. They are usually asymptomatic and <2cm but sometimes can be bigger. It is diagnosed with pelvic examination. It is treated with surgicalexcision of the cyst. This is a unique case in urogynecology as it confuses with pelvic organ prolapseand the mode of treatment is completely different. We report a case of 32-years old lady whopresented in urogynecology outpatient department with complain of pelvic organ prolapse. Afterexamination she was diagnosed as vaginal cyst and excision was done and confirmed as Gartnerscyst in histopathological examination.

scholarly journals Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

2018 ◽  
Vol 50 (3) ◽  
pp. 1113-1122 ◽  
Author(s):  
Fan Xu ◽  
Jing Ma ◽  
Hongyan Yi ◽  
Huiquan Hu ◽  
Liangsheng Fan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Uterine Cervix ◽  
Chemotherapy Regimen ◽  
Radical Surgery ◽  
Meta Analysis ◽  
Figo Stage ◽  
Small Cell ◽  
Small Cell Lung ◽  
Poor Survival ◽  
Small Cell Neuroendocrine Carcinoma

Background/Aims: To evaluate the clinicopathologic aspects of small cell neuroendocrine carcinoma of the uterine cervix (SCNEC). Methods: A retrospective review of 40 patients with SCNEC in 3 hospitals from 2009 to 2015 was conducted to assess the survival rates and examine the associations between clinicopathological variables and overall survival (OS). A meta-analysis of 22 studies containing 1901 patients was also conducted to further confirm the results. Results: In the clinical group of 40 patients, the 5-year OS rate was 20%. Advanced International Federation of Gynecology and Obstetrics (FIGO) stage and radiation therapy (RT) were associated with poor survival. However, radical surgery was associated with prolonged survival. In the meta-analysis of 1901 patients, the 2-year disease-free survival (DFS) rate, 5-year DFS rate, 2-year OS rate, 3-year OS rate and 5-year OS rate of SCNEC were 48%, 35%, 62%, 35%, and 35% respectively. Advanced FIGO stage, larger tumor size, lymph node metastasis (LNM) (+), lymphovascular space involvement (LVSI) (+), parametrial involvement (PI) (+), depth of stromal invasion (DSI) > 2/3, and RT were associated with poor survival. However, a chemotherapy regimen similar to that for small cell lung cancer was associated with prolonged survival. Conclusion: Advanced FIGO stage, larger tumor size, LNM (+), LVSI (+), DSI > 2/3, PI (+), and RT were independent predictors of poor prognosis of SCNEC. Radical surgery combined with a chemotherapy regimen similar to that of small cell lung cancer may be a potential therapeutic approach for SCNEC.

scholarly journals Vocal Cord Leukoplakia: Characteristics and Pathological Significance

2012 ◽  
Vol 2 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Yusuf Kizil ◽  
Utku Aydil ◽  
Metin Yilmaz ◽  
Özgür Ekinci ◽  
Osman Tugrul Güzeldir ◽  
...  
Keyword(s):  
High Risk ◽  
Vocal Cord ◽  
Chronic Inflammation ◽  
Clinical Diagnosis ◽  
Cancer Diagnosis ◽  
Histopathological Examination ◽  
Pathological Finding ◽  
Smoking History ◽  
White Patch ◽  
Mild Dysplasia

ABSTRACT Leukoplakia is a nonspecific clinical term used to describe a mucosal white patch or plaque that cannot be easily scraped off. Leukoplakia of vocal cord represents a chronic inflammation or exposure to irritants which can also stimulate development of precancerous conditions or cancer. This study aimed to determine clinical and histopathological characteristics of vocal cord leukoplakia. A total of 66 patients were included. All patients with a clinical diagnosis of vocal cord leukoplakia who had undergone direct laryngoscopic examination and biopsy were analyzed retrospectively. The most common pathological finding was mild dysplasia (25.8%). Cancer was detected in 18.2% of cases. Malignancy was more frequent in cases with unilateral vocal cord involvement (23.4%) when compared with bilateral cases (5.2%) and in patients with localized lesions (19.3%) when compared with lesions involving whole cord (11.1%), but the differences were not statistically significant (p > 0.05). Smoking history was found to be related with cancer diagnosis (p < 0.001). In the presence of a serious smoking history, there is high-risk for malignancy and leukoplakia should be sampled immediately for histopathological examination. Although statistically not proven, cancer rates are higher in more localized and unilateral lesions. How to cite this article Kizil Y, Aydil U, Yilmaz M, Ekinci Ö, Güzeldir OT, Savas VA, Köybasioglu A. Vocal Cord Leukoplakia: Characteristics and Pathological Significance. Int J Phonosurg Laryngol 2012;2(1):9-13.

Nonfunctional parathyroid cancer − a case report

2021 ◽  
Vol 100 (3) ◽  
Keyword(s):  
Case Report ◽  
Parathyroid Hormone ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Treatment Protocol ◽  
Normal Serum ◽  
Parathyroid Cancer ◽  
En Bloc ◽  
Mortality And Morbidity ◽  
Severe Hypercalcemia

Introduction: Parathyroid cancer is a rare endocrine malignancy. These tumors are typically functional, causing severe hypercalcemia due to primary hyperparathyroidism. Nonfunctional parathyroid cancer with normal serum calcium and parathyroid hormone levels is extremely rare. The disease is usually indolent but progressive with a tendency to metastasize. It is very difficult to diagnose this malignancy. The definitive diagnosis is made by histopathological examination. Radical surgery with ipsilateral lobectomy and en bloc neck dissection is considered to be the most appropriate therapeutic approach. There is no evidence of efficiency of adjuvant cancer therapy and its indication has not been defined. Disease recurrence is common. Case report: We report the case of a 26-year-old female patient who underwent left hemithyroidectomy for growth progression of a hypoechoic lesion behind the left thyroid lobe detected by ultrasonography. Preoperative cytology and imaging assessments were not suspicious for malignancy. Serum parathyroid hormone and calcium levels were normal. The diagnosis of nonfunctional parathyroid carcinoma was determined based on histopathological examination. No further surgery or adjuvant therapy was indicated. No signs of recurrence or generalization have been observed at 36 months after the surgery. Conclusion: Nonfunctional parathyroid cancer is extremely rare. In many cases, the diagnosis is made in advanced stages of the disease. No formal classification or treatment protocol has been established so far. A new staging system has been proposed in the 8th edition of AJCC/UICC. Early detection, radical surgery and close follow-up are crucial aspects to affect the mortality and morbidity of patients with this type of malignancy.

scholarly journals Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094791
Author(s):  
Xu Li ◽  
Dezhao Li ◽  
Xiaodong Sun ◽  
Guoyue Lv
Keyword(s):  
Histopathological Examination ◽  
Distant Metastases ◽  
Ampulla Of Vater ◽  
Chinese Patient ◽  
Ki 67 ◽  
Rare Tumour ◽  
Mixed Adenoneuroendocrine Carcinoma ◽  
Dark Urine ◽  
Neoplastic Lesion ◽  
Enhanced Computed Tomography

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract with both epithelial and neuroendocrine components. We describe a case of a 57-year-old man who presented with yellow sclera and dark urine. Contrast-enhanced computed tomography (CT) showed enlargement of the intra and extrahepatic bile ducts and a neoplastic lesion at the end of the common bile duct which was indistinguishable from the adjacent head of the pancreas and duodenum. A pancreaticoduodenectomy was performed and histopathological examination of resected samples showed that tumour was a complex lesion with adenocarcinoma and neuroendocrine components positive for neuroendocrine markers (chromogranin A and synaptophysin) with a Ki-67 labelling index of 40%. The patient was diagnosed with MANEC in the ampulla of Vater with a neuroendocrine carcinoma component of approximately 70%. Ampullary MANECs are highly aggressive tumours with a high risk for distant metastases and a poor prognosis. Therefore, establishing a standard therapeutic strategy is crucial.

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