scholarly journals Melanosis of the Uterine Cervix: A Rare Case Report

2021 ◽  
Author(s):  
Nikhil Sanjay Deshpande ◽  
Aditi Mittal ◽  
Anil B Munemane ◽  
Ravindra Raosaheb Karle
Keyword(s):  
Uterine Cervix ◽  
Histopathological Examination ◽  
Basal Layer ◽  
Pathological Finding ◽  
Final Diagnosis ◽  
Pathological Examination ◽  
Macular Lesion ◽  
Melanocytic Lesions ◽  
Rare Case Report ◽  
S 100

Cervical melanosis is a rare entity in the spectrum of melanocytic lesions of uterine cervix. Melanosis is defined as presence of melanocytes in the basal layer of squamous epithelium causing hyperpigmentation. Authors here by report a case of 57-year-old female who underwent vaginal hysterectomy for third degree utero-vaginal prolapse, showed an incidental gross pathological finding of brownish macular lesion. Histopathological examination showed hyperpigmentation of basal layer without increase in melanocytes. On immunohistochemical examination, basal melanocytes were highlighted by S-100 and HMB 45 immunostains. Thus final diagnosis of cervical melanosis was made. Clinical differentials of cervical pigmented melanocytic lesions include cervical melanomas, blue nevi, congenital or traumatic lesions and melanosis, hence vigilant clinical, gross pathological examination and biopsy is warranted.

scholarly journals Micropapillary variant of transitional cell carcinoma in a young adult: a rare case report

2019 ◽  
Vol 6 (8) ◽  
pp. 3028
Author(s):  
Sasanka Kumar Barua ◽  
Ashish Ghanghoria ◽  
Saumar Jyoti Baruah ◽  
Rajeev T. P. ◽  
Puskal Kumar Bagchi ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Transitional Cell ◽  
Lateral Wall ◽  
Metastatic Potential ◽  
Pathological Examination ◽  
High Grade ◽  
Macroscopic Hematuria ◽  
Rare Case Report

Micropapillary carcinoma is an uncommon variant of urothelial carcinoma with high metastatic potential. Usually seen in elderly individual, we herein report a case of 42 years old man presented with macroscopic hematuria for 1 month. Evaluation with CECT whole abdomen revealed irregularly marginated hyperattenuated mildly enhancing intraluminal mass lesions in right lateral wall and in floor of urinary bladder. No perivesical infiltration and no regional lymphadenopathy were detected. TURBT done and subsequent histopathological examination showed a high-grade transitional cell carcinoma with micropapillary variant. He was subjected to radical cystoprostatectomy with pelvic lymph node dissection. The pathological examination revealed a high-grade transitional cell carcinoma with micropapillary variant invading the perivesical adipose tissue. No tumor recurrence or metastasis was reported at the 18-months follow-up.

scholarly journals Duodenal gangliocytic paraganglioma: a rare case report

2020 ◽  
Author(s):  
Jing Li ◽  
Lu-Ping Wang ◽  
Pei-Shuang Zhu
Keyword(s):  
Pathological Examination ◽  
Epithelioid Cells ◽  
Gangliocytic Paraganglioma ◽  
Sessile Polyp ◽  
Sustentacular Cells ◽  
Spindle Cells ◽  
Spindle Cell Proliferation ◽  
Rare Case Report ◽  
Pancreas Islet ◽  
S 100

Abstract Background Gangliocytic paraganglioma (GP) is quite rare, and origin and entity remain to be elucidated. Case presentation A 51-year-old male presented with a sessile polyp with smooth surface measured about 1cm in diameter in the descending portion of duodenum. Pathological examination displayed a neoplasm located in submucosa, infiltrating into lamina propria. The tumor consisted of epithelioid, ganglion-like and spindle cells admixing in a haphazard way. The epithelioid cells resembled paraganglioma in cytological and architectural features, the ganglion-like cells was scattered, and the spindle cells resembled neurofibroma. Syn, MAP-2 and CgA were positive in the epithelioid and ganglion-like cells in variety and NF highlighted the ganglion-like cells. S-100 and SOX-10 were positive in the sustentacular cells around the epithelioid cells and spindle cell proliferation. PR was also positive. Conclusions Origin of GP is presumed to be related with pancreas islet. GP is supposed to be distinguished with NET G1 and designated as paraganglioma-ganglioneuroma, a kind of composite paraganglioma.

scholarly journals Leiomyoma of the vulva: a diagnostic challenge

2018 ◽  
Vol 7 (3) ◽  
pp. 1246
Author(s):  
Shilpi Saxena ◽  
Suyash Goel ◽  
Alok D. Sen
Keyword(s):  
Smooth Muscle ◽  
Histopathological Examination ◽  
Critical Role ◽  
Final Diagnosis ◽  
Reproductive Age ◽  
Pathological Examination ◽  
Diagnostic Challenge ◽  
Duct Cyst ◽  
Smooth Muscle Tumors ◽  
Rule Out

Smooth muscle tumours of vulva are rare and therefore can be missed clinically. Our patient, 48-year-old lady presented with lump in the left vulva that was clinically diagnosed as Bartholin duct cyst. The lumpectomy was done under local anaesthesia and the lesion was sent for pathological examination. On gross examination the mass was 3.5 cm in diameter. The microscopic examination revealed the lump to be leiomyoma and no necrosis or atypia was present. The final diagnosis of “vulval leiomyoma” was given. Postoperative period was uneventful, and the patient is on regular follow up and there has been no recurrence. Leiomyoma should be kept as a differential diagnosis when a lady presents in late reproductive age group with unilateral swelling in vulvar region which is firm in consistency and the lump must be sent for histopathological examination for definitive diagnosis and rule out malignancy. The pathologists play a critical role in recognition and management of smooth muscle tumors of the vulva and to rule out leiomyosarcoma.

Granular Cell Tumor of the Neurohypophysis With TFE-3 Expression: A Rare Case Report

2017 ◽  
Vol 25 (8) ◽  
pp. 751-754 ◽  
Author(s):  
Guang-Zhi Yang ◽  
Jing Li
Keyword(s):  
Granular Cell Tumor ◽  
Translocation Factor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Pathological Examination ◽  
Rare Case Report ◽  
S 100 ◽  
The Central Nervous System ◽  
Pas Staining

Granular cell tumor (GCT) rarely involves the central nervous system, and fewer than 100 cases have been reported in English literatures. We herein report a case of a 36-year-old Chinese man with GCT of the neurohypophysis. Magnetic resonance imaging showed one mass located in the hypophysis with heterogeneous contrast enhancement. Pathological examination showed a neoplasm comprising densely packed polygonal cells of ample cytoplasm with abundant eosinophilic granules inside. The nuclei were small with inconspicuous nucleoli and yet without any mitoses. The tumor was positive for S-100, CD68, CD163, lysosome, and vimentin. Translocation factor E-3 (TFE-3) was diffusely nuclear positive although ASPSCR1-TFE-3 fusion was not detected by fluorescence in situ hybridization. GCT of the neurohypophysis is supposed to be considered under differential diagnosis with neoplasms or lesions of histiocytic origin and others such as pituitocytoma and spindle cell oncocytoma. A group of markers such as GFAP, EMA, CD68, S-100, and PAS staining are useful in complementary diagnosis and TFE-3 may be an alternative marker.

scholarly journals Intraosseous schwannoma of the proximal humerus with pathologic fracture

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Jiang Huajun ◽  
Qu Wei ◽  
Wu Yuxuan ◽  
Yang Jingjing
Keyword(s):  
Proximal Humerus ◽  
Pathologic Fracture ◽  
Bone Allograft ◽  
Excisional Biopsy ◽  
Final Diagnosis ◽  
Pathological Examination ◽  
Ki 67 ◽  
Intraosseous Schwannoma ◽  
S 100 ◽  
The Right

Abstract Background Intraosseous schwannomas are extremely rare in the humerus, and less than five cases have been reported previously in the literature. This is the first report of its origin in the proximal humerus with pathologic fracture. We herein present this case to discuss the reason for its rarity and share our experience of management. Case presentation A 55-year-old female patient presented with pain in the right shoulder, which was caused by tripping and falling over a board. Radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) showed considerable tumor in proximal humerus, which connected with a fracture. For this suspected tumor, we performed two operations. Pathological examination demonstrated typical picture of a schwannoma, showing whorls and interlacing fascicles of schwannoma spindle cells. Immunohistochemistry, the tumor cells were diffusely positive for S-100 protein, SOX-10 and CD68, while they were completely negative for desmin, DOG-1, AE1/AE3 and P63. The Ki-67 index was about 10%. No mitoses or features of malignancy were identified. The final diagnosis of intraosseous schwannoma was made. The treatment for intraosseous schwannoma with pathologic fracture includes excisional biopsy, curettage, bone allograft, and fracture fixation. The patient recovered well. After the surgery, the patient gradually regained mobility and the pain subsided. There was no recurrence after 6 months of follow-up by X-ray. Conclusions Although very rare, intraosseous schwannoma should be taken under consideration in the differential diagnosis of benign-appearing osseous tumor in the proximal humerus with pathologic fracture.

scholarly journals Multiple Primary Angiosarcomas of the Colon

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Sonja Radić ◽  
Mario Zovak ◽  
Anita Galović Marić ◽  
Stjepan Baturina ◽  
Monica Stephany Kirigin ◽  
...  
Keyword(s):  
Gluteus Medius ◽  
Final Diagnosis ◽  
Soft Tissue Tumors ◽  
Multiple Organ ◽  
Multiple Primary ◽  
Rare Case Report ◽  
S 100 ◽  
Organ Failures ◽  
Diagnostic Difficulties ◽  
Initial Hospitalization

Introduction. Gastrointestinal angiosarcomas are rare and represent less than 1% of all gastrointestinal tract malignancies, with most occurring in the stomach and small intestine. Occurrence in the colorectal segments is considered extremely rare. Case Report. We describe the case of a 61-year-old male with multiple primary angiosarcomas of the colon who presented with fever and abdominal pain. The patient was initially hospitalized and treated as having an infectious disease. A multislice computed tomography (MSCT) scan revealed multiple soft tissue tumors in the region of the left iliopsoas and gluteus medius muscles. After developing hematochezia, a colonoscopy was performed which found an ulcerated tumor in the sigmoid colon. The small tissue biopsy taken during the procedure presented diagnostic difficulties and was given a preliminary diagnosis of gastrointestinal stromal tumor (GIST). Examination of the resected colon segment and surrounding fat tissue revealed four separate tumors. Microscopically, the tumors were composed of solid sheets of spindle and epithelioid neoplastic cells with prominent nucleoli and numerous mitotic figures and immunohistochemically positive for ERG, CD31, CD34, vimentin, and CD117, while negative for CK7, CK20, CD20, CD3, CD45, TTF-1, PAN-CK, ALK, Mpox, S-100, and DOG1, leading to the final diagnosis of multiple colonic angiosarcomas. The patient’s condition declined rapidly and he passed away from multiple organ failures 60 days after initial hospitalization. Conclusion. Both clinical and pathological diagnoses of colorectal angiosarcoma are challenging. Patients are present with nonspecific symptoms leading to mismanagement and late diagnosis. A definitive pathological diagnosis relies on immunohistochemical staining for endothelial markers. Misdiagnosis as poorly differentiated adenocarcinoma or GIST is possible in limited tissue biopsies.

scholarly journals Histopathological Examination of Intervertebral Disc Specimens: A Cost-Benefit Analysis

2007 ◽  
Vol 34 (4) ◽  
pp. 451-455 ◽  
Author(s):  
Adam S. Wu ◽  
Daryl R. Fourney
Keyword(s):  
Intervertebral Disc ◽  
Cost Benefit Analysis ◽  
Histopathological Examination ◽  
Pathological Finding ◽  
Cost Benefit ◽  
Histopathological Finding ◽  
Pathological Examination ◽  
Indications For Surgery ◽  
Benefit Analysis ◽  
Clinically Significant

Object:Routine histopathological examination of intervertebral disc specimens is commonly performed in North American hospitals, but recent studies have questioned the utility of this practice in cases where the indication for surgery is a benign process such as degenerative disc disease. In this study, we have performed a cost-benefit analysis of this practice.Methods:We performed a cost-benefit analysis of routine histopathological examination of 1775 routine (non-neoplastic and non-infectious indications for surgery) and 70 non-routine (suspected neoplastic or infectious indications for surgery) discectomy specimens obtained over an eight-year period (1996 and 2004). Chart reviews were used to determine if any histopathology findings were clinically significant (i.e., affected subsequent patient care). Total costs were calculated. A literature review was conducted to compare our results with other published series.Results:We found four unexpected histopathology results among 1775 specimens obtained from routine cases, one of which was clinically significant. We calculated costs of $42,165.25 per unexpected histopathological finding and $168,625 per clinically significant histopathological finding. For non-routine surgeries, the cost per abnormal pathological finding was $116.67.Conclusions:In routine cases, histopathological examination of disc specimens is not justified. The decision to send specimens for pathological examination should be based on the surgeon's judgment.

scholarly journals Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants

2019 ◽  
Vol 12 (3) ◽  
pp. e227050 ◽  
Author(s):  
Bárbara Ribeiro ◽  
Raquel Silva ◽  
Renata Dias ◽  
Vanda Patrício
Keyword(s):  
Uterine Cervix ◽  
Radical Surgery ◽  
Histopathological Examination ◽  
Pathological Finding ◽  
Sarcomatous Component ◽  
Rare Tumour ◽  
Distant Disease ◽  
Mesonephric Duct ◽  
Mullerian Ducts ◽  
Mesonephric Carcinoma

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. We describe a case of a 64-year-old woman, presenting with vaginal bleeding and a cervical lesion reported as a sarcoma of endometrial stroma in the first biopsy. After exclusion of distant disease, she was submitted to radical surgery and the final histopathological examination showed a carcinosarcoma of the cervix with mesonephric origin.

F.N.A.C. AS DIAGNOSTIC TOOL OF PAROTID TUMORS AND ASSOCIATED PITFALLS IN CORRELATION WITH HISTOPATHOLOGY

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Bhawana Pant ◽  
Sanjay Gaur ◽  
Prabhat Pant
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Clinical Information ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cytological Diagnosis ◽  
Tertiary Referral Centre ◽  
Clear Cut ◽  
Parotid Tumors

F.NA.C has been used for ages as a safe and economical tool for fast preoperative diagnosis of parotid tumors. It has certain pitfall which sometimes leads to misdiagnosis and consequently it may have affect on treatment of the tumors. Keeping in view of the diverse classification of parotid tumors’ information from cytology should be combined with radiology as well as clinical diagnosis. Aim: To discuss some cases where there was discrepancy between cytological diagnosis and histopathological result and also suggest measures to improve the efficacy of F.N.A.C. Material and methods: The study includes 50 cases of parotid tumours who presented to the  department of ENT at Government medical college Haldwani which is a tertiary referral centre during 2009 to 2016. Only adult patients were included and inflammatory swelling were excluded from the study. All patients evaluated  Contrast enhanced computerized tomography(CECT) and  Magnetic resonance imaging (MRI) followed by Fine needle aspiration cytology .Preoperative diagnosis was made upon the findings of the above investigations and different types of  parotid surgeries  were done. . Final diagnosis was made on  histopathological  examination. Result :The most common tumour  came out to be pleomorphic adenoma (23 cases-46%) followed by mucoepidermoid carcinoma(12cases-24%). In ten  cases there was no clear cut  association between cytological diagnosis and final histopathological diagnosis. Conclusion: FNAC is highly sensitive and specific technique for diagnosis of many salivary gland swellings. FNAC can be used preoperatively to avoid unnecessary surgery and biopsy. Details of clinical information and radiologic features may help the pathologist to arrive at the appropriate diagnosis and reduce false interpretation. Pitfalls may also occur with improper technique of FNAC which can be overcome by proper caution.

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