Peritoneal lesions caused by Enterobius vermicularis suspected to be metastases of ovarian malignancy

2021 ◽  
Vol 14 (7) ◽  
pp. e238618
Author(s):  
Britt Croonen ◽  
Angèle Oei ◽  
Suzanne Mol ◽  
Peter Schneeberger
Keyword(s):  
Vaginal Bleeding ◽  
Rare Complication ◽  
Transvaginal Ultrasound ◽  
Lower Abdominal Pain ◽  
Ovarian Malignancy ◽  
Enterobius Vermicularis ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Multilocular Cyst ◽  
Last Stage

Enterobius vermicularis, also known as pinworm, is a helminth that commonly causes intestinal parasitic infestation. E. vermicularis can also cause extraintestinal infestations. We report a case of lower abdominal pain and intermittent vaginal bleeding in a 45-year-old woman who was referred to our gynaecology department. On investigation, a transvaginal ultrasound showed a multilocular cyst in the left ovary, along with elevated levels of cancer antigen 125. Consequently, a laparoscopic salpingo-oophorectomy was performed. A biopsy of atypical peritoneal lesions revealed remains of E. vermicularis. Peritoneal lesions are a rare complication of enterobiasis, and the diagnosis of this complication is usually delayed by limitations in diagnostic options. Although extraintestinal enterobiasis does not require treatment because it is the last stage of the parasitic cycle, primary intestinal infestation requires treatment with mebendazole.

scholarly journals Uterine artery pseudoaneurysm after treatment of cesarean scar pregnancy: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiao Wang ◽  
Qing Yang ◽  
Ningning Zhang ◽  
Dandan Wang
Keyword(s):  
Vaginal Bleeding ◽  
Uterine Artery ◽  
Rare Complication ◽  
Transvaginal Ultrasound ◽  
Massive Hemorrhage ◽  
Cesarean Scar Pregnancy ◽  
Artery Pseudoaneurysm ◽  
Cesarean Scar ◽  
Effective Diagnosis ◽  
Uterine Artery Pseudoaneurysm

Abstract Background Pseudoaneurysms are formed when a local arterial wall ruptures, leading to hemorrhage and hematoma adjacent to the artery. Continuous perfusion of the injured artery increases the pressure in the lumen of the pseudoaneurysm. It may rupture and lead to massive hemorrhage that could be life-threatening. Cesarean scar pregnancy (CSP) is an ectopic pregnancy where the gestational sac is implanted in the cesarean scar. Uterine artery pseudoaneurysm (UAP) after CSP treatment is rare. Case presentation We report the case of a 36-year-old Chinese woman who presented with acute massive vaginal bleeding 53 days after transabdominal scar pregnancy excision. Doppler ultrasound confirmed UAP. Selective uterine artery embolization (UAE) failed because of the thin and curved blood vessels. The lesion decreased in size after transvaginal ultrasound-guided direct thrombin injection (UGTI); however, massive vaginal bleeding recurred and endangered the patient’s life. The uterus was removed thereafter. Conclusions UAP is a rare complication after CSP treatment that can lead to fatal massive hemorrhage. Ultrasound should be reexamined regularly after treatment of CSP. In case of unexplained vaginal bleeding, we should be alert to the existence of UAP and the possibility of rupture and take effective diagnosis and treatment measures promptly.

Evaluation in the predictive value of serum human epididymal protein 4 (HE4), cancer antigen 125 (CA 125) and a combination of both in detecting ovarian malignancy

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Beng Hock Teh ◽  
Soon Leong Yong ◽  
Wee Wee Sim ◽  
Kim Bee Lau ◽  
Haris Njoo Suharjono
Keyword(s):  
Predictive Value ◽  
Area Under The Curve ◽  
Pelvic Mass ◽  
Premenopausal Women ◽  
Ca 125 ◽  
Diagnostic Study ◽  
Ovarian Malignancy ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Sensitivity Specificity

Abstract Background This study was conducted to evaluate the performance of human epididymal protein 4 (HE4), cancer antigen 125 (CA 125) and a combination of both via the Risk of Ovarian Malignancy Algorithm (ROMA) in detecting ovarian malignancy. Methods This was a diagnostic study enrolling 129 patients with pelvic mass(es) suspected of originating in the ovary who had been scheduled for surgery or radiological-guided biopsy. Serum HE4 and CA 125 levels were measured. HE4, CA 125 and ROMA were evaluated for sensitivity, specificity, positive predictive value and negative predictive value. The receiver operating characteristic (ROC) plots were graphed and area under the curve (AUC) values were calculated to investigate the accuracy of each marker for predicting ovarian malignancy. Results Overall, CA 125 remained significantly more sensitive (88.9% vs. 51.9%, p = 0.006) but less specific (56.9% vs. 95.1%, p < 0.001) than HE4. HE4 was superior to CA 125 in specificity (97.7% vs. 54.5%, p < 0.001) for premenopausal women. ROMA was non-significantly more sensitive (100.0% vs. 92.3%, p = 1.000) than CA 125 but both were equally specific (71.4%) for the postmenopausal group. In the premenopausal group, the AUC of serum HE4 was higher than serum CA 125 (0.851 vs. 0.817) but was equivalent to ROMA (0.851 vs. 0.859). In the postmenopausal group, ROMA exhibited an excellent AUC value as compared to CA 125 and HE4 (AUC of 0.907 vs. 0.874 vs. 0.863, respectively). Conclusion HE4 is useful in ruling out ovarian malignancy among premenopausal women. For postmenopausal women, ROMA appears to be an all-rounder with overall good sensitivity and specificity.

Cancer Antigen 125 Associated With Multiple Benign and Malignant Pathologies

2003 ◽  
Vol 10 (2) ◽  
pp. 150-154 ◽  
Author(s):  
C. Miralles ◽  
M. Orea ◽  
P. Espa�a ◽  
M. Provencio ◽  
A. S�nchez ◽  
...  
Keyword(s):  
Cancer Antigen 125 ◽  
Cancer Antigen

Variability of effluent cancer antigen 125 and interleukin-6 determination in peritoneal dialysis patients

2011 ◽  
Vol 26 (11) ◽  
pp. 3739-3744 ◽  
Author(s):  
D. Lopes Barreto ◽  
A. M. Coester ◽  
M. Noordzij ◽  
W. Smit ◽  
D. G. Struijk ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Interleukin 6 ◽  
Dialysis Patients ◽  
Cancer Antigen 125 ◽  
Cancer Antigen

Predictive value of serum human epididymis protein 4 and cancer antigen 125 concentrations in endometrial carcinoma

2013 ◽  
Vol 209 (2) ◽  
pp. 142.e1-142.e6 ◽  
Author(s):  
Sami K. Saarelainen ◽  
Nina Peltonen ◽  
Terho Lehtimäki ◽  
Antti Perheentupa ◽  
Maarit H. Vuento ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Predictive Value ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Human Epididymis Protein 4 ◽  
Human Epididymis

scholarly journals Cancer antigen 125 is associated with disease status in uterine carcinosarcoma

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131988415
Author(s):  
Malcolm Strachan Ross ◽  
Chelsea Kilpatrick Chandler ◽  
Koji Matsuo ◽  
John Austin Vargo ◽  
Esther Elishaev ◽  
...  
Keyword(s):  
Overall Survival ◽  
Uterine Cancer ◽  
Disease Status ◽  
Post Treatment ◽  
Uterine Carcinosarcoma ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Time Points ◽  
Potential Biomarker ◽  
Significant Difference

Uterine carcinosarcoma is a rare and aggressive tumor with poor outcomes. Cancer antigen 125 is routinely used to track the disease course of ovarian cancer and has been suggested as a biomarker in other aggressive forms of uterine cancer. We sought to characterize cancer antigen 125 as a potential biomarker of disease status in uterine carcinosarcoma. Clinical and pathological data were abstracted for patients who had surgical staging for a pathologically confirmed uterine carcinosarcoma at our institution from January 2000 to March 2014. Non-parametric tests were used to compare changes in cancer antigen 125. Elevated cancer antigen 125 (>35 U/mL) as a predictor of survival was assessed via Kaplan–Meier curves. Among the 153 patients identified, 66 patients had at least one paired measure of cancer antigen 125 drawn preoperatively, post-treatment, or at the time of disease recurrence, and 19 patients had cancer antigen–125 levels at all three time points. Analysis of the 51 patients with both preoperative and post-treatment values found a significant drop in cancer antigen 125 ( p < 0.001). Among the 30 patients who had end-of-treatment and recurrence levels, a significant increase was noted ( p = 0.001). There was no significant difference in cancer antigen–125 levels preoperatively compared to at recurrence among the 23 patients with levels at both time-points ( p = 0.99). Elevated preoperative cancer antigen 125 was not associated with overall survival ( p = 0.12); elevated post-treatment cancer antigen 125 was associated with a worse overall survival ( p < 0.001). Based on this dataset, there seems to be utility in trending a cancer antigen–125 level in patients with uterine carcinosarcoma. A cancer antigen–125 level could predict recurrence and provide prognostic information regarding survival.

Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study

2014 ◽  
Vol 93 (12) ◽  
pp. 1295-1301 ◽  
Author(s):  
Pal B. Szecsi ◽  
Malene R. Andersen ◽  
Brian Bjørngaard ◽  
Katrine K. Hedengran ◽  
Steen Stender
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Normal Pregnancy ◽  
Cancer Antigen 125 ◽  
Cancer Antigen
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