Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection

We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. A biphasic calcaemic response was observed with initial severe hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite haemodialysis. Control of the calcium levels was achieved by continuous haemofiltration.

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Severe hypercalcaemia and acute kidney Injury in a patient with sarcoidosis

Endocrine Abstracts ◽

10.1530/endoabs.65.p127 ◽

2019 ◽

Author(s):

Emily Whiles ◽

Hareesh Joshi ◽

Arun P Perumalthiagarajan ◽

Amina Mohammed ◽

Samson O Oyibo ◽

...

Keyword(s):

Acute Kidney Injury ◽

Kidney Injury ◽

Severe Hypercalcaemia

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Elevation of creatine kinase is associated with acute kidney injury in hospitalized patients infected with seasonal influenza virus

Clinical and Experimental Nephrology ◽

10.1007/s10157-020-02006-3 ◽

2021 ◽

Author(s):

Kento Ishibuchi ◽

Hirotaka Fukasawa ◽

Mai Kaneko ◽

Hideo Yasuda ◽

Ryuichi Furuya

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Influenza Virus ◽

Seasonal Influenza ◽

Kidney Injury ◽

Hospitalized Patients

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Predictors of acute kidney injury in patients after extracorporeal cardiopulmonary resuscitation

Perfusion ◽

10.1177/02676591211049767 ◽

2021 ◽

pp. 026765912110497

Author(s):

Christopher Gaisendrees ◽

Borko Ivanov ◽

Stephen Gerfer ◽

Anton Sabashnikov ◽

Kaveh Eghbalzadeh ◽

...

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

High Risk ◽

Cardiopulmonary Resuscitation ◽

Hospital Mortality ◽

Hospital Stay ◽

Kidney Injury ◽

Dialysis Patients ◽

Extracorporeal Cardiopulmonary Resuscitation ◽

Outcome Parameters

Objectives: Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly used due to its beneficial outcomes and results compared with conventional CPR. Data after eCPR for acute kidney injury (AKI) are lacking. We sought to investigate factors predicting AKI in patients who underwent eCPR. Methods: From January 2016 until December 2020, patients who underwent eCPR at our institution were retrospectively analyzed and divided into two groups: patients who developed AKI ( n = 60) and patients who did not develop AKI ( n = 35) and analyzed for outcome parameters. Results: Overall, 63% of patients suffered AKI after eCPR and 45% of patients who developed AKI needed subsequent dialysis. Patients who developed AKI showed higher values of creatinine (1.1 mg/dL vs 1.5 mg/dL, p ⩽ 0.01), urea (34 mg/dL vs 42 mg/dL, p = 0.04), CK (creatine kinase) (923 U/L vs 1707 U/L, p = 0.07) on admission, and CK after 24 hours of ECMO support (1705 U/L vs 4430 U/L, p = 0.01). ECMO explantation was significantly more often performed in patients who suffered AKI (24% vs 48%, p = 0.01). In-hospital mortality (86% vs 70%; p = 0.07) did not differ significantly. Conclusion: Patients after eCPR are at high risk for AKI, comparable to those after conventional CPR. Baseline urea levels predict the development of AKI during the hospital stay.

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Unusual Case of Localized Upper Limbs and Truncal Edema Associated with Fever, Anemia, and Acute Kidney Injury

Case Reports in Medicine ◽

10.1155/2019/6251426 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

Mohammad Tinawi

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Muscle Biopsy ◽

Unusual Case ◽

Kidney Injury ◽

The Other ◽

Upper Limbs ◽

Inflammatory Myositis ◽

Arm Pain ◽

Extensive Evaluation

The patient is a 75-year-old man who presented with right arm pain, edema, and erythema. The same manifestations appeared in the other arm 3 weeks later. He also developed fever, acute kidney injury, anemia, and truncal edema. Initial extensive evaluation was unrevealing. He was noted to have elevated creatine kinase, and a diagnostic muscle biopsy lead to diagnosis of inflammatory myositis. He improved with corticosteroids.

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Caffeine Overdose Complicated by Acute Kidney Injury despite Mild Creatine Kinase Elevation

Case Reports in Acute Medicine ◽

10.1159/000507181 ◽

2020 ◽

Vol 3 (1) ◽

pp. 12-16 ◽

Cited By ~ 1

Author(s):

Nao Koide ◽

Nobuhiro Sato ◽

Daisuke Kondo ◽

Yasuo Hirose

Keyword(s):

Emergency Department ◽

Acute Kidney Injury ◽

Creatine Kinase ◽

Suicide Attempt ◽

Case Reports ◽

Kidney Injury ◽

Elevated Creatine Kinase ◽

Caffeine Overdose

Caffeine is a commonly used stimulant in our society. Prior case reports have described acute caffeine overdose resulting in rhabdomyolysis and acute kidney injury (AKI). We present the case of a 29-year-old man who presented to the emergency department after ingesting 20.1 g of caffeine in a suicide attempt and experienced AKI with only mildly elevated creatine kinase (CK). This case highlights the possibility that AKI can result from a caffeine overdose, even if the patient’s CK is only slightly elevated.

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How to do it: investigate exertional rhabdomyolysis (or not)

Practical Neurology ◽

10.1136/practneurol-2018-002008 ◽

2018 ◽

Vol 19 (1) ◽

pp. 43-48 ◽

Cited By ~ 7

Author(s):

Peter M Fernandes ◽

Richard J Davenport

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Kidney Injury ◽

Underlying Disease ◽

Serum Creatine Kinase ◽

Muscle Disease ◽

Initial Presentation ◽

Organ Support ◽

Exertional Rhabdomyolysis ◽

Substantial Rise

Rhabdomyolysis is the combination of symptoms (myalgia, weakness and muscle swelling) and a substantial rise in serum creatine kinase (CK) >50 000 IU/L; there are many causes, but here we specifically address exertional rhabdomyolysis. The consequences of this condition can be severe, including acute kidney injury and requirement for higher level care with organ support. Most patients have ‘physiological’ exertional rhabdomyolysis with no underlying disease; they do not need investigation and should be advised to return to normal activities in a graded fashion. Rarely, exertional rhabdomyolysis may be the initial presentation of underlying muscle disease, and we review how to identify this much smaller group of patients, who do require investigation.

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Relationship of creatine kinase elevation and acute kidney injury in pediatric trauma patients

Journal of Trauma and Acute Care Surgery ◽

10.1097/ta.0b013e318278954e ◽

2013 ◽

Vol 74 (3) ◽

pp. 912-916 ◽

Cited By ~ 12

Author(s):

Peep Talving ◽

Efstathios Karamanos ◽

Dimitra Skiada ◽

Lydia Lam ◽

Pedro G. Teixeira ◽

...

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Pediatric Trauma ◽

Kidney Injury ◽

Trauma Patients ◽

Relationship Of

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Case Report: Exertional rhabdomyolysis in a spin class participant with sickle cell trait

F1000Research ◽

10.12688/f1000research.16326.2 ◽

2019 ◽

Vol 7 ◽

pp. 1742

Author(s):

Teresa Longo ◽

Matthew Shaines

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Case Report ◽

Sickle Cell ◽

Renal Injury ◽

Sickle Cell Trait ◽

Kidney Injury ◽

Exertional Rhabdomyolysis ◽

At Risk Populations ◽

First Time

Exertional rhabdomyolysis is more common in sickle trait due to a predisposition to dehydration and inability to concentrate the urine. Spinning, an indoor cycling workout, has been associated with exertional rhabdomyolysis in recent reports. A consequence of rhabdomyolysis is acute kidney injury, which may be expected to be more common in patients with sickle trait. We report a case of spinning induced rhabdomyolysis in a woman with sickle trait that did not result in renal injury. “Spin rhabdo” is thought to be more severe than other causes of exertional rhabdomyolysis and is associated with higher creatine kinase levels than other causes of exertional rhabdomyolysis. Therefore, individuals with known sickle trait should consider visiting their physician prior to participation in spin classes for the first time. We might also consider voluntary screening for sickle trait in at risk populations prior to enrolling in spin classes given that many patients are unaware of their sickle trait status.

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Case Report: Exertional rhabdomyolysis in a spin class participant with sickle cell trait

F1000Research ◽

10.12688/f1000research.16326.1 ◽

2018 ◽

Vol 7 ◽

pp. 1742 ◽

Cited By ~ 2

Author(s):

Teresa Longo ◽

Matthew Shaines

Keyword(s):

Acute Kidney Injury ◽

Creatine Kinase ◽

Case Report ◽

Sickle Cell ◽

Renal Injury ◽

Sickle Cell Trait ◽

Kidney Injury ◽

Exertional Rhabdomyolysis ◽

At Risk Populations ◽

First Time

Exertional rhabdomyolysis is more common in sickle trait due to a predisposition to dehydration and inability to concentrate the urine. Spinning, an indoor cycling workout, has been associated with exertional rhabdomyolysis in recent reports. A consequence of rhabdomyolysis is acute kidney injury, which may be expected to be more common in patients with sickle trait. We report a case of spinning induced rhabdomyolysis in a woman with sickle trait that did not result in renal injury. “Spin rhabdo” is thought to be more severe than other causes of exertional rhabdomyolysis and is associated with higher creatine kinase levels than other causes of exertional rhabdomyolysis. Therefore, individuals with known sickle trait should visit their physician prior to participation in spin classes for the first time. We might also consider voluntary screening for sickle trait in at risk populations prior to enrolling in spin classes given that many patients are unaware of their sickle trait status.

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