Elevation of creatine kinase is associated with acute kidney injury in hospitalized patients infected with seasonal influenza virus

2021 ◽  
Author(s):  
Kento Ishibuchi ◽  
Hirotaka Fukasawa ◽  
Mai Kaneko ◽  
Hideo Yasuda ◽  
Ryuichi Furuya
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Influenza Virus ◽  
Seasonal Influenza ◽  
Kidney Injury ◽  
Hospitalized Patients

scholarly journals Acute Kidney Injury in hospitalized patients with COVID-19 and seasonal influenza: A comparative analysis

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0007322020
Author(s):  
Bhavna Bhasin ◽  
Vineet Veitla ◽  
Aprill Z. Dawson ◽  
Zhuping Garacci ◽  
Daniel Sturgill ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
African American ◽  
Comparative Analysis ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Multivariable Analysis ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
African American Race

Background: Coronavirus disease 2019 (COVID-19) is often compared to seasonal influenza and the two diseases share similarities including the risk of systemic manifestations such as acute kidney injury (AKI). The aim of this study was to perform a comparative analysis of the prevalence, risk factors, and outcomes of AKI in hospitalized patients with COVID-19 and influenza. Methods: Retrospective cohort study of hospitalized patients with COVID-19 (n=325) or seasonal influenza (n=433). AKI was defined by Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Baseline characteristics and hospitalization data were collected, and multivariable analysis was performed to determine the independent predictors for AKI. Results: AKI occurred in 32.6% of COVID-19 hospitalizations (COV-AKI) and 33.0% of influenza hospitalizations (FLU-AKI). After adjusting for age, gender, and comorbidity count, the risk of stage 3 AKI was significantly higher in COV-AKI (OR: 3.46; 95% CI 1.63, 7.37). Preexisting CKD was associated with a 6- to 7-fold increased likelihood for FLU-AKI and COV-AKI. Mechanical ventilation was associated with a higher likelihood of developing AKI in the COVID-19 cohort (OR: 5.85; 95% CI 2.30, 15.63). African American race, after adjustment for comorbidities, was an independent risk for COV-AKI. Conclusion: Pre-existing CKD was a major risk factor for AKI in both cohorts. African American race (independent of comorbidities) and mechanical ventilation were associated with a higher risk of developing COV-AKI which is characterized by a higher burden of stage 3 AKI and overall poorer prognosis.

scholarly journals Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection

2021 ◽  
Vol 14 (5) ◽  
pp. e239611
Author(s):  
Adrian Po Zhu Li ◽  
Stephen Thomas ◽  
Refik Gokmen ◽  
Dulmini Kariyawasam
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Calcium Homeostasis ◽  
Kidney Injury ◽  
Severe Hypercalcaemia ◽  
Severe Hypocalcaemia

We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. A biphasic calcaemic response was observed with initial severe hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite haemodialysis. Control of the calcium levels was achieved by continuous haemofiltration.

Low sodium to potassium ratio in spot urine sample is associated with progression to acute kidney injury and mortality in hospitalized patients with cirrhosis

2021 ◽  
Author(s):  
Elayne Cristina Morais Rateke ◽  
Camila Matiollo ◽  
Emerita Quintina de Andrade Moura ◽  
Michelle Andrigueti ◽  
Claudia Maccali ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Urine Sample ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
Spot Urine ◽  
Low Sodium ◽  
Spot Urine Sample

scholarly journals Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Isaac E Hall ◽  
Edward P Stern ◽  
Lloyd G Cantley ◽  
Jack A Elias ◽  
Chirag R Parikh
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

scholarly journals Morbid Obesity Is Associated With Mortality And Acute Kidney Injury In Hospitalized Patients With Covid-19

2021 ◽  
Author(s):  
Martín-del-Campo Fabiola ◽  
Ruvalcaba-Contreras Neri ◽  
Velázquez-Vidaurri Alma L ◽  
Cueto-Manzano Alfonso M ◽  
Rojas-Campos Enrique ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Hospitalized Patients

Predictors of acute kidney injury in patients after extracorporeal cardiopulmonary resuscitation

Perfusion ◽  
2021 ◽  
pp. 026765912110497
Author(s):  
Christopher Gaisendrees ◽  
Borko Ivanov ◽  
Stephen Gerfer ◽  
Anton Sabashnikov ◽  
Kaveh Eghbalzadeh ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
High Risk ◽  
Cardiopulmonary Resuscitation ◽  
Hospital Mortality ◽  
Hospital Stay ◽  
Kidney Injury ◽  
Dialysis Patients ◽  
Extracorporeal Cardiopulmonary Resuscitation ◽  
Outcome Parameters

Objectives: Extracorporeal cardiopulmonary resuscitation (eCPR) is increasingly used due to its beneficial outcomes and results compared with conventional CPR. Data after eCPR for acute kidney injury (AKI) are lacking. We sought to investigate factors predicting AKI in patients who underwent eCPR. Methods: From January 2016 until December 2020, patients who underwent eCPR at our institution were retrospectively analyzed and divided into two groups: patients who developed AKI ( n = 60) and patients who did not develop AKI ( n = 35) and analyzed for outcome parameters. Results: Overall, 63% of patients suffered AKI after eCPR and 45% of patients who developed AKI needed subsequent dialysis. Patients who developed AKI showed higher values of creatinine (1.1 mg/dL vs 1.5 mg/dL, p ⩽ 0.01), urea (34 mg/dL vs 42 mg/dL, p = 0.04), CK (creatine kinase) (923 U/L vs 1707 U/L, p = 0.07) on admission, and CK after 24 hours of ECMO support (1705 U/L vs 4430 U/L, p = 0.01). ECMO explantation was significantly more often performed in patients who suffered AKI (24% vs 48%, p = 0.01). In-hospital mortality (86% vs 70%; p = 0.07) did not differ significantly. Conclusion: Patients after eCPR are at high risk for AKI, comparable to those after conventional CPR. Baseline urea levels predict the development of AKI during the hospital stay.

scholarly journals Unusual Case of Localized Upper Limbs and Truncal Edema Associated with Fever, Anemia, and Acute Kidney Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Mohammad Tinawi
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Muscle Biopsy ◽  
Unusual Case ◽  
Kidney Injury ◽  
The Other ◽  
Upper Limbs ◽  
Inflammatory Myositis ◽  
Arm Pain ◽  
Extensive Evaluation

The patient is a 75-year-old man who presented with right arm pain, edema, and erythema. The same manifestations appeared in the other arm 3 weeks later. He also developed fever, acute kidney injury, anemia, and truncal edema. Initial extensive evaluation was unrevealing. He was noted to have elevated creatine kinase, and a diagnostic muscle biopsy lead to diagnosis of inflammatory myositis. He improved with corticosteroids.

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