Generalised eruptive histiocytosis preceded by systemic symptoms

2021 ◽  
Vol 14 (6) ◽  
pp. e243411
Author(s):  
Caitlyn N Myrdal ◽  
Delaney B Stratton ◽  
Tracy L Davis ◽  
Clara Curiel-Lewandrowski
Keyword(s):  
Weight Loss ◽  
Chronic Inflammation ◽  
Spindle Cell ◽  
Langerhans Cell ◽  
Histological Evaluation ◽  
General Malaise ◽  
Histological Findings ◽  
Proliferative Disease ◽  
Systemic Symptoms ◽  
Dermal Infiltrate

Generalised eruptive histiocytosis is a rare proliferative disease that typically presents with indolent cutaneous eruptions. We describe the case of a 73-year-old man presenting with diffuse, asymptomatic crops of pink to dusky red papules preceded by general malaise, myalgias, fluctuating fever, chills, and weight loss. Histological evaluation revealed a non-Langerhans cell histiocytic dermal infiltrate with spindle cell features and chronic inflammation, reactive for CD68 and negative for both S100 and CD1a. Malignancy screening was negative. This report aims to highlight a unique presentation of generalised eruptive histiocytosis, emphasise histological findings, and discuss considerations for malignancy screening.

Management of regional enteritis

1966 ◽  
Vol 4 (23) ◽  
pp. 90-91
Keyword(s):  
Weight Loss ◽  
Small Bowel ◽  
Chronic Inflammation ◽  
Regional Enteritis ◽  
Skin Lesions ◽  
Blind Loop Syndrome ◽  
Electrolyte Disturbance ◽  
Extensive Involvement ◽  
Acute Ileitis ◽  
Disturbance Growth

Regional enteritis (Crohn’s disease) is an uncommon chronic inflammation of unknown cause involving one or more parts of the gut.1–3 The affected parts are often thickened: the mucosa is usually ulcerated and there may be adhesions and fistulae. This can cause diarrhoea, steatorrhoea, pain, and acute and chronic obstruction. Malabsorption occurs in extensive involvement of the small bowel or in the ‘blind loop’ syndrome due to strictures, fistulae or by-pass operations, and in addition protein may be lost in the bowel. The fistulae may occur between loops of bowel, and anal fistulae are common. These disorders can cause malaise, fever, anaemia, weight loss, hypoproteinaemia and electrolyte disturbance. Growth may be arrested. Skin lesions, arthropathy and iritis may develop. The first attack may occur at any age, and the disease usually runs a chronic and unpredictable course. However, acute ileitis, diagnosed surgically, does not usually recur,4–6 and it may be a different condition.6

Osteoarthritis, Gout, and Infectious Arthritis

2016 ◽  
pp. 813-828
Author(s):  
Clement J. Michet ◽  
Floranne C. Ernste
Keyword(s):  
Weight Loss ◽  
Neck Pain ◽  
Nerve Root ◽  
Overuse Injury ◽  
Systemic Disease ◽  
Infectious Arthritis ◽  
Systemic Symptoms

Cervicothoracic complaints can be classified into 3 categories on the basis of etiology: mechanical, neurogenic, and pain secondary to other systemic processes. Mechanical neck complaints are often secondary to trauma, overuse injury, malposture, and osteoarthritis. Neurogenic neck complaints are experienced acutely after trauma or gradually as a result of progressive osteoarthritis with subsequent nerve root impingement. Neck pain secondary to systemic disease often is associated with systemic symptoms such as fever, chills, weight loss, rash, polyarthralgia, or polymyalgia.

Mediastinal tumours and cysts

2020 ◽  
pp. 4368-4376
Author(s):  
Y.C. Gary Lee ◽  
Helen E. Davies
Keyword(s):  
Weight Loss ◽  
Posterior Mediastinum ◽  
Anatomical Site ◽  
Detailed Knowledge ◽  
Malignant Tumours ◽  
Important Group ◽  
Abnormal Chest ◽  
Mediastinal Tumours ◽  
Middle Mediastinum ◽  
Systemic Symptoms

Mediastinal masses are most conveniently categorized by their anatomical site in the anterior, middle, or posterior mediastinum. Most present as a radiographic abnormality alone, or in association with symptoms arising from compression of other mediastinal structures. Systemic symptoms such as fever or weight loss are more likely with malignant tumours such as lymphomas or thymomas. Detailed knowledge of normal mediastinal anatomy is a prerequisite to the interpretation of both normal and abnormal chest radiographs. Lymph nodes are present in all three compartments thereby knowledge of their anatomical relationships, together with sites of drainage, is important when interpreting radiographic mediastinal enlargement. The most important group of visceral nodes lie in the middle mediastinum and are predominantly subcarinal and paratracheal. Bronchopulmonary and hilar nodes are numerous but not visible radiographically unless pathologically enlarged.

scholarly journals Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

2014 ◽  
Vol 1 ◽  
pp. 57-61 ◽  
Author(s):  
Halina Cichoż-Lach ◽  
Beata Prozorow-Król ◽  
Jarosław Swatek ◽  
Barbara Skrzydło-Radomańska ◽  
Leszek Buk ◽  
...  
Keyword(s):  
Weight Loss ◽  
Systemic Amyloidosis ◽  
General Malaise

Chronic Haemolytic Anemia and Splenomegaly in a Patient with an Isolated Adrenocorticotropin Deficiency

2008 ◽  
Vol 1 ◽  
pp. CMED.S406
Author(s):  
Rania Abdel-Muneem Ahmed ◽  
Koji Murao ◽  
Hitomi Imachi ◽  
Noriko Kitanaka ◽  
Tomie Muraoka ◽  
...  
Keyword(s):  
Weight Loss ◽  
General Malaise ◽  
Laboratory Studies ◽  
Adrenocortical Insufficiency ◽  
Progressive Weight Loss ◽  
Haemolytic Anemia

Herein we describe a case of a 56-years old patient presented with general malaise, anorexia and progressive weight loss for about 5years associated recently with diarrhoea and repeated syncopal attacks for 1month. On admission, he had splenomegaly and his laboratory studies showed macrocytic hyperchromic haemolytic anemia [Hb = 9.4g/dl] and a significant hyponatremia [Na+ = 111mmol/l]. Endocrinological evaluation revealed an isolated adrenocorticotropin deficiency (IAD) with a manifest hypoaldosteronism. On treatment with cortisone, both anemia and hyponatremia (but not splenomegaly) were markedly improved. Our case may represent an evidence for the pathogenesis of erythropoietic dysfunction in patients of adrenocortical insufficiency.

scholarly journals Bariatric Surgery: Remission of Inflammation, Cardiometabolic Benefits, and Common Adverse Effects

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Fatimo Biobaku ◽  
Husam Ghanim ◽  
Scott V Monte ◽  
Joseph A Caruana ◽  
Paresh Dandona
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Adverse Effects ◽  
Chronic Inflammation ◽  
Large Scale ◽  
Severe Obesity ◽  
Neurological Complications ◽  
The Common ◽  
Underlying Mechanisms ◽  
Remission Of Comorbidities

Abstract Obesity is associated with increased mortality as a result of several comorbidities which occur in tandem with the obese state. Chronic inflammation is well documented in obesity, and evidence from numerous studies support the notion that the increased inflammation in individuals with obesity accentuates the comorbidities seen in this condition. The remission of comorbidities such as metabolic, cardiovascular, and neurological complications occurs following bariatric procedures. Bariatric surgery significantly reduces mortality and results in remarkable weight loss and reversal in several obesity-related comorbidities. There is indisputable evidence that the resolution of inflammation that occurs after bariatric surgery mitigates some of these comorbidities. With the increasing use of bariatric surgery for the treatment of severe obesity, it is pivotal to elucidate the underlying mechanisms responsible for the notable improvements seen after the procedure. This review summarizes underlying mechanisms responsible for the remission of obesity-related abnormalities and discusses the common adverse effects of bariatric surgery. Well-stratified, large-scale studies are still needed for a proper evaluation of these underlying mechanisms.

scholarly journals Epididymo-Orchitis as a Presenting Feature of Relapsing Polychondritis: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Kuljeet Bhamra ◽  
Rachel Weerasinghe ◽  
Alan Steuer
Keyword(s):  
Weight Loss ◽  
Case Report ◽  
Blood Vessels ◽  
Diagnostic Test ◽  
Relapsing Polychondritis ◽  
Immunosuppressive Drugs ◽  
Bronchial Tree ◽  
Multisystem Disease ◽  
Systemic Symptoms ◽  
Recurrent Inflammation

Relapsing polychondritis (RP) is a rare multisystem disease. It is characterized by recurrent inflammation of cartilaginous structures including the ears, nose, tracheo-bronchial tree and peripheral joints. Proteoglycan-rich structures such as the heart, eyes and blood vessels can also be affected. Systemic symptoms including fever, weight loss and lethargy are common. RP is difficult to diagnose as it presents in a wide variety of ways and there is no diagnostic test. Corticosteroids are the mainstay of treatment but other immunosuppressive drugs can be used in combination with steroids. We present an unusual presentation of RP.

scholarly journals Controversies on Rituximab Therapy in Sjögren Syndrome-Associated Lymphoproliferation

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Luca Quartuccio ◽  
Martina Fabris ◽  
Sara Salvin ◽  
Marta Maset ◽  
Ginevra De Marchi ◽  
...  
Keyword(s):  
B Cell ◽  
Chronic Inflammation ◽  
Lupus Erythematosus ◽  
B Cell Lymphoma ◽  
Systemic Autoimmune Disease ◽  
Low Grade ◽  
Anca Associated Vasculitis ◽  
Open Issue ◽  
Gland Function ◽  
Systemic Symptoms

Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lachrymal glands, and frequently accompanied by systemic symptoms. A subgroup of SS patients develops malignant B cell non-Hodgkin's lymphoma (NHL), usually of the mucosa-associated lymphoid tissue (MALT) type and very often located in the major salivary glands. Currently, there is a lack of evidence-based intervention therapy which may influence SS-related chronic inflammation and lymphoproliferation. B cells are involved in the pathogenesis of SS, and B cell downregulation may lead to a decrease of disease activity. Rituximab (RTX), a chimeric monoclonal antibody targeting the CD20 antigen on the B cell surface, has been successfully investigated in other autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, ANCA-associated vasculitis, and mixed cryoglobulinemic syndrome. Preliminary experiences of RTX therapy in SS patients with or without a lymphoproliferative disorder suggest that SS patients with more residual exocrine gland function might better benefit from RTX. Efficacy of RTX in SS-associated B-cell lymphoma, mainly in low-grade salivary gland lymphomas, remains an open issue.

scholarly journals Systemic Spindle-Cell Proliferative Disease in Broiler Chickens

2005 ◽  
Vol 67 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Shigeaki TAKAMI ◽  
Masanobu GORYO ◽  
Toshiaki MASEGI ◽  
Kosuke OKADA
Keyword(s):  
Broiler Chickens ◽  
Spindle Cell ◽  
Proliferative Disease
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