Chronic Haemolytic Anemia and Splenomegaly in a Patient with an Isolated Adrenocorticotropin Deficiency

2008 ◽  
Vol 1 ◽  
pp. CMED.S406
Author(s):  
Rania Abdel-Muneem Ahmed ◽  
Koji Murao ◽  
Hitomi Imachi ◽  
Noriko Kitanaka ◽  
Tomie Muraoka ◽  
...  
Keyword(s):  
Weight Loss ◽  
General Malaise ◽  
Laboratory Studies ◽  
Adrenocortical Insufficiency ◽  
Progressive Weight Loss ◽  
Haemolytic Anemia

Herein we describe a case of a 56-years old patient presented with general malaise, anorexia and progressive weight loss for about 5years associated recently with diarrhoea and repeated syncopal attacks for 1month. On admission, he had splenomegaly and his laboratory studies showed macrocytic hyperchromic haemolytic anemia [Hb = 9.4g/dl] and a significant hyponatremia [Na+ = 111mmol/l]. Endocrinological evaluation revealed an isolated adrenocorticotropin deficiency (IAD) with a manifest hypoaldosteronism. On treatment with cortisone, both anemia and hyponatremia (but not splenomegaly) were markedly improved. Our case may represent an evidence for the pathogenesis of erythropoietic dysfunction in patients of adrenocortical insufficiency.

scholarly journals Prevalence of paratuberculosis infection in sheep

2014 ◽  
Vol 68 (3-4) ◽  
pp. 165-174
Author(s):  
Branka Vidic ◽  
Zivoslav Grgic ◽  
Milovan Jovicin ◽  
Zoran Rasic ◽  
Sara Savic ◽  
...  
Keyword(s):  
Weight Loss ◽  
Preventive Measures ◽  
Clinical Signs ◽  
Elisa Test ◽  
Positive Finding ◽  
Clinical Form ◽  
Control Programs ◽  
Progressive Weight Loss ◽  
Mycobacterium Avium Subsp Paratuberculosis ◽  
Positive Results

Paratuberculosis is an incurable chronic disease of ruminants, which is manifested with clinical signs of diarrhea and progressive weight loss. Causative agent is Mycobacterium avium subsp. paratuberculosis, and the disiase occurs in cattle, sheep and goats. The outspread of paratuberculosis is huge in the whole world, especially in the countries where animal breeding is a developed branch of economy. Animals get infected with food and water contaminated with feces of infected animals. The infection spreads within infected pastures and also when trading animals with latent infection. Clinical manifestation of the disease can firstly be noticed in young categories of sheep, which is different than in cattle. Primary clinical symptom is chronic weight loss. It is rather hard to determine the level of prevalence of the disease, in a certain region, because the diagnostic procedure is complex and not always reliable enough. Detection of antibodies with ELISA test is considered a method of choice for diagnostic of paratuberculosis, because of fast gaining of the results and relatively low price of the test. By applying the ELISA test, we have analysed 2000 sheep blood samples. Positive results for paratuberculosis were found in 66 ( 3,30%) animals in total. In sheep samples from southern Backa region, positive findings were gained from 42 (3,89%) samples, and in Srem region, positive finding were found in samples from 24 sheep (2,60%). Control programs are based on the removal of all infected animals, application of general preventive measures and vaccination. Application of vaccination aims for elimination of clinical form of the disease. An effective treatment has not been determined so far.

scholarly journals Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

2014 ◽  
Vol 1 ◽  
pp. 57-61 ◽  
Author(s):  
Halina Cichoż-Lach ◽  
Beata Prozorow-Król ◽  
Jarosław Swatek ◽  
Barbara Skrzydło-Radomańska ◽  
Leszek Buk ◽  
...  
Keyword(s):  
Weight Loss ◽  
Systemic Amyloidosis ◽  
General Malaise

Antiviral and myocyte protective effects of murine interferon-β and -α2in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice

2007 ◽  
Vol 293 (1) ◽  
pp. H69-H76 ◽  
Author(s):  
Yi-Xin Wang ◽  
Valdeci da Cunha ◽  
Jon Vincelette ◽  
Kathy White ◽  
Sharlene Velichko ◽  
...  
Keyword(s):  
Weight Loss ◽  
Viral Load ◽  
Cardiac Tissue ◽  
Thrombus Formation ◽  
Coxsackievirus B3 ◽  
Protective Effects ◽  
Inflammatory Infiltration ◽  
Differential Host ◽  
Progressive Weight Loss ◽  
Myocyte Damage

The present study tested the hypothesis that murine (m)IFN-β or mIFN-α2can eliminate cardiac viral load and protect cardiomyocytes from injury in animals infected with coxsackievirus B3 (CVB3). CVB3-inoculated male Balb/c mice exhibited signs of illness, including lethargy, progressive weight loss, and death (10% on day 3 and 100% on day 8). Cardiac viral load was high [4,277 ± 1,009 plaque-forming units and 25 ± 5 copies CVB3/hypoxanthine guanine phosphoribosyl transferase 1 mRNA] on day 4. The cardiac tissue exhibited severe inflammatory infiltration and myocyte damage with an average myocarditis integrated pathology score of 2.1 ± 0.2 on day 7. Most of the mice infected with CVB3 also developed epicarditis, and 55% had intraventricular thrombi present. Treatment with mIFN-β [2.5 to 10 million international units (MIU)/kg] dose-dependently improved the general health status in CVB3-inoculated mice, as evidenced by reduction in weight loss, prevention of death, elimination of cardiac viral load, protection of myocytes from injury, decrease in inflammatory cell infiltration, and attenuation of intraventricular thrombus formation. Treatment with 10 MIU/kg mIFN-α2resulted in a similar level of efficacy as that induced by 5 MIU/kg mIFN-β, with the exception that mIFN-α2did not reduce cardiac CVB3 mRNA. However, mIFN-α2, but not any dose group of mIFN-β, significantly attenuated CVB3-induced epicarditis. These data demonstrate antiviral effects for both mIFN-β and mIFN-α2, which lead to protection of the mice from CVB3-induced myocarditis. However, the potential mechanisms leading to a differential host response for the two isoforms of mIFN remain to be elucidated.

THE EFFECT OF METHOPRENE, AN INSECT GROWTH REGULATOR, ON MUSCA DOMESTICA (DIPTERA: MUSCIDAE)

1977 ◽  
Vol 107 (4) ◽  
pp. 413-417 ◽  
Author(s):  
Philip B. Morgan ◽  
G. C. LaBrecque ◽  
D. E. Weidhaas ◽  
A. Benton
Keyword(s):  
Weight Loss ◽  
Musca Domestica ◽  
Larval Mortality ◽  
Exposure Period ◽  
Insect Growth Regulator ◽  
Laboratory Studies ◽  
House Flies ◽  
Poultry Droppings ◽  
Topical Applications ◽  
Low Order

AbstractMethoprene, when incorporated into the food of laying hens at concentrations of 0.005 and 0.01%, produced 70.9 and 99.3% larval mortality, respectively, among house flies (Musca domestica L.) reared in the resultant poultry droppings. Exposure to the treated diet did not produce any weight loss in the chickens. However, it was not effective when the poultry droppings were treated topically under field conditions. In laboratory studies, when incorporated with moistened droppings, concentrations of 0.001 and 0.0001% produced complete larval mortality throughout a 7-day exposure period, though only 98% mortality was achieved on the first day at the higher concentration. Concentrations of 0.5 and 1.08 of the compound in fly food produced only a low order of sterility. Topical applications produced a low order of sterility except in the insecticide-susceptible females.

Repeated lifestyle interventions lead to progressive weight loss: A retrospective review chart study

2017 ◽  
Vol 45 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Sune Dandanell ◽  
Christian Ritz ◽  
Elisabeth Verdich ◽  
Flemming Dela ◽  
Jørn W. Helge
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Retrospective Review ◽  
Fat Free Mass ◽  
Lifestyle Interventions ◽  
Weight Cycling ◽  
Weight Loss Programme ◽  
Progressive Weight Loss ◽  
Lost To Follow Up

Aims: This study aimed to investigate whether repeated lifestyle interventions lead to progressive weight loss or to weight cycling. Methods: A retrospective review chart study with follow-up on 2120 participants (mean±SD age 36±15 years; body weight 116±28 kg; fat 43±6%). All had participated in one to four 11–12 week lifestyle interventions (residential weight loss programme, mixed activities). Weight loss was promoted through a hypocaloric diet (−500 to −700 kcal/day) and daily physical activity (1–3 hours/day). Primary outcomes were weight loss and change in body composition (bioimpedance measurements) after the intervention periods and at follow-up. Results: A total of 2120, 526, 139 and 47 people participated in one to four interventions with mean±SEM times from start to follow-up of 1.3±0.1, 2.9±0.2, 4.2±0.3 and 5.2±0.4 years respectively. Overall 50, 41, 18 and 11% of the participants were lost to follow-up after one to four interventions, respectively. The cumulated weight loss at follow-up increased with the number of interventions from one to four: 12.2±0.1, 15.9±0.7, 16.1±1.2 and 18.5±2.0 kg ( p<0.001). The ratios between cumulated loss of fat and fat free mass after one to four interventions decreased with the number of interventions (2.4, 2.2, 2.1 and 1.4). Rates of weight loss during the interventions ranged from 0.70±0.06 to 1.06±0.01 kg/week and the maximum weight regain during the follow-up periods was 0.039±0.007 kg/week. Conclusions: Repeated relatively short lifestyle interventions in a selected and motivated group can be an efficient method for weight loss maintenance with only limited body weight cycling in the interim periods. However, the relationship between loss of fat and fat free mass might change in an unfavourable direction.

scholarly journals Malnutrition: from pathogenesis to current methods for diagnosis and treatment

2017 ◽  
Vol 89 (12-2) ◽  
pp. 216-225
Author(s):  
O I Kostyukevich ◽  
S V Sviridov ◽  
A K Rylova ◽  
N V Rylova ◽  
M I Korsunskaya ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Loss ◽  
Clinical Practice ◽  
Nutritional Status ◽  
Clinical Significance ◽  
Nutritional Support ◽  
Substantial Impact ◽  
Risk Of Death ◽  
Progressive Weight Loss ◽  
Somatic Diseases

Progressive weight loss is a frequent companion to somatic pathology. The risk of death is known to increase dramatically among those with a body mass index of less than 19 kg/m. Even mild weight loss in the presence of severe diseases can have a substantial impact on the course of the disease. The paper presents current views on malnutrition, its prevalence in the presence of various somatic diseases, and clinical significance. It describes the basic pathogenetic components of weight loss and the possible ways of correcting nutritional status. Particular emphasis is placed on the methods of nutritional support that is currently regarded as one of the most important components of a comprehensive approach to treating patients with chronic diseases. The authors give recommendations for the assessment of the nutritional status of patients in clinical practice and algorithms for their malnutrition management.

scholarly journals Hepatic sarcoidosis resembling primary sclerosing cholangitis

2021 ◽  
Vol 14 (9) ◽  
pp. e243492
Author(s):  
Ying Chen ◽  
Camelia Ciobanu ◽  
Laurel Mohrmann
Keyword(s):  
Weight Loss ◽  
Abdominal Pain ◽  
Magnetic Resonance ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Correct Diagnosis ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Night Sweats ◽  
Progressive Weight Loss ◽  
Hepatic Sarcoidosis

We report the case of a 29-year-old man who presented with progressive weight loss, night sweats, abdominal pain and pruritus who was found to have obstructive jaundice and cholestatic pattern of liver injury on laboratory workup. Though findings on magnetic resonance cholangiopancreatography were initially concerning primary sclerosing cholangitis, he was ultimately diagnosed with biliary sarcoidosis after a liver biopsy. This case brings attention to the rare phenomenon of hepatic sarcoidosis causing hyperbilirubinemia and highlights the importance of reaching the correct diagnosis early, as the patient’s symptoms improved after initiation of steroids.

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