International standards for symphysis-fundal height based on serial measurements from the Fetal Growth Longitudinal Study of the INTERGROWTH-21stProject: prospective cohort study in eight countries

Background: Several kinds of motor dysfunction can predict future cognitive impairment in elderly individuals. However, the ability of the fine motor index (FINEA) and gross motor index (GROSSA) to predict the risk of cognitive impairment has not been assessed. Objective: We investigated the associations between FINEA/GROSSA and cognitive impairment. Methods: The data of 4,745 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). We first assessed the correlation between the FINEA GROSSA and MMSE in a cross-sectional study. Then, we further investigated the predictive role of the incidence of cognitive impairment in a prospective cohort study. Results: We found that both FINEA and GROSSA were negatively correlated with MMSE in both the unadjusted (FINEA: B = –1.00, 95%confidence intervals (CI): –1.17, –0.83, t = –11.53, p < 0.001; GROSSA: B = –0.85, 95%CI: –0.94, –0.76, t = –18.29, p < 0.001) and adjusted (FINEA: B = –0.63, 95%CI: –0.79, –0.47, t = –7.77, p < 0.001; GROSSA: B = –0.57, 95%CI: –0.66, –0.48, t = –12.61, p < 0.001) analyses in a cross-sectional study. In a prospective cohort study, both high FINEA and high GROSSA were associated with an increased incidence of cognitive function impairment (FINEA: adjusted odds ratios (OR) = 2.35, 95%CI: 1.05, 5.23, p = 0.036; GROSSA adjusted OR = 3.00, 95%CI: 1.49, 6.03, p = 0.002) after 2 years of follow-up. Conclusion: Higher FINEA and GROSSA scores were both associated with an increased incidence of cognitive impairment. FINEA or GROSSA might be a simple tool for identifying patients with cognitive impairment.

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Screening for fetal growth restriction using ultrasound and the sFLT1/PlGF ratio in nulliparous women: a prospective cohort study

The Lancet Child & Adolescent Health ◽

10.1016/s2352-4642(18)30129-9 ◽

2018 ◽

Vol 2 (8) ◽

pp. 569-581 ◽

Cited By ~ 38

Author(s):

Francesca Gaccioli ◽

Ulla Sovio ◽

Emma Cook ◽

Martin Hund ◽

D Stephen Charnock-Jones ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Prospective Cohort ◽

Growth Restriction ◽

Nulliparous Women ◽

Plgf Ratio

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Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort study

Genetics and Molecular Research ◽

10.4238/2015.april.27.2 ◽

2015 ◽

Vol 14 (2) ◽

pp. 3879-3888

Author(s):

F. Xiong ◽

Y. Tong ◽

P. Li ◽

T. Huo ◽

M. Mao

Keyword(s):

Cohort Study ◽

Pregnancy Outcome ◽

Prospective Cohort Study ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Prospective Cohort ◽

Immunoglobulin E ◽

Growth Restriction ◽

Serum Immunoglobulin

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Prevalence of Frailty Assessed by Fried and Kihon Checklist Indexes in a Prospective Cohort Study: Design and Demographics of the Kyoto-Kameoka Longitudinal Study

Journal of the American Medical Directors Association ◽

10.1016/j.jamda.2017.02.022 ◽

2017 ◽

Vol 18 (8) ◽

pp. 733.e7-733.e15 ◽

Cited By ~ 35

Author(s):

Yosuke Yamada ◽

Hinako Nanri ◽

Yuya Watanabe ◽

Tsukasa Yoshida ◽

Keiichi Yokoyama ◽

...

Keyword(s):

Cohort Study ◽

Longitudinal Study ◽

Prospective Cohort Study ◽

Study Design ◽

Prospective Cohort ◽

Cohort Study Design

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Accelerated Fetal Growth in Early Pregnancy and Risk of Preterm Birth: A Prospective Cohort Study

10.21203/rs.3.rs-39242/v1 ◽

2020 ◽

Author(s):

Evangelia Elenis ◽

Anna-Karin Wikström ◽

Marija Simic

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Prospective Cohort Study ◽

Fetal Growth ◽

Early Pregnancy ◽

Prospective Cohort ◽

Late Gestation ◽

Second Trimester ◽

Spontaneous Preterm Birth ◽

Increased Risk

Abstract Background: Preterm birth (occurring before 37 completed weeks of gestation) affects 15 million infants annually, 7.5% of which die due to related complications. The detection and early diagnosis are therefore paramount in order to prevent the development of prematurity and its consequences. So far, focus has been laid on the association between reduced intrauterine fetal growth during late gestation and prematurity. The aim of the current study was to investigate the association between accelerated fetal growth in early pregnancy and the risk of preterm birth. Methods: This prospective cohort study included 69 617 singleton pregnancies without congenital malformations and with available biometric measurements during the first and second trimester. Estimation of fetal growth was based on measurements of biparietal diameter (BPD) at first and second trimester scan. We investigated the association between accelerated fetal growth and preterm birth prior to 37 weeks of gestation. The outcome was further stratified into very preterm birth (before 32 weeks of gestation) or moderate preterm birth (between 32 and 37 weeks of gestation) and medically induced or spontaneous preterm birth and was further explored. Results: The odds of prematurity were increased among fetuses with accelerated BPD growth (> 90th centile) estimated between first and second ultrasound scan, even after adjustment for possible confounders (aOR 1.36; 95% CI 1.20-1.54). The findings remained significant what regards moderate preterm births but not earlier births. Regarding medically induced preterm birth, the odds were found to be elevated in the group of fetuses with accelerated growth in early pregnancy (aOR 1.34; 95% CI 1.11-1.63). On the contrary, fetuses with delayed fetal growth exhibited lower risk for both overall and spontaneous preterm birth.Conclusions: Fetuses with accelerated BPD growth in early pregnancy, detected by ultrasound examination during the second trimester, exhibited increased risk of being born preterm. The findings of the current study suggest that fetal growth in early pregnancy should be taken into account when assessing the likelihood for preterm birth.

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