Spousal concordance in pathophysiological markers and risk factors for type 2 diabetes: a cross-sectional analysis of The Maastricht Study

IntroductionWe compared the degree of spousal concordance in a set of detailed pathophysiological markers and risk factors for type 2 diabetes to understand where in the causal cascade spousal similarities are most relevant.Research design and methodsThis is a cross-sectional analysis of couples who participated in The Maastricht Study (n=172). We used quantile regression models to assess spousal concordance in risk factors for type 2 diabetes, including four adiposity measures, two dimensions of physical activity, sedentary time and two diet indicators. We additionally assessed beta cell function and insulin sensitivity and glucose metabolism status with fasting and 2-hour plasma glucose and hemoglobin A1c.ResultsThe strongest spousal concordance (beta estimates) was observed for the Dutch Healthy Diet Index (DHDI) in men. A one-unit increase in wives’ DHDI was associated with a 0.53 (95% CI 0.22 to 0.67) unit difference in men’s DHDI. In women, the strongest concordance was for the time spent in high-intensity physical activity (HPA); thus, a one-unit increase in husbands’ time spent in HPA was associated with a 0.36 (95% CI 0.17 to 0.64) unit difference in women’s time spent in HPA. The weakest spousal concordance was observed in beta cell function indices.ConclusionsSpousal concordance was strongest in behavioral risk factors. Concordance weakened when moving downstream in the causal cascade leading to type 2 diabetes. Public health prevention strategies to mitigate diabetes risk may benefit from targeting spousal similarities in health-related behaviors and diabetes risk factors to design innovative and potentially more effective couple-based interventions.

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Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes: a possible link suggested by cross-sectional analysis

Endocrine Journal ◽

10.1507/endocrj.ej11-0206 ◽

2012 ◽

Vol 59 (3) ◽

pp. 187-195 ◽

Cited By ~ 12

Author(s):

Yoshifumi Saisho ◽

Kumiko Tanaka ◽

Takayuki Abe ◽

Akira Shimada ◽

Toshihide Kawai ◽

...

Keyword(s):

Type 2 Diabetes ◽

Beta Cell ◽

Beta Cell Function ◽

Cell Function ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Sectional Analysis

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Selective association of electrocardiographic abnormalities with insulin sensitivity and beta-cell function in type 2 diabetes mellitus: a cross-sectional analysis

Diabetes/Metabolism Research and Reviews ◽

10.1002/dmrr.2794 ◽

2016 ◽

Vol 32 (7) ◽

pp. 736-744 ◽

Cited By ~ 2

Author(s):

Anish B. Bhatt ◽

Claire K. Mulvey ◽

Atif N. Qasim ◽

Jayamohan V. Nair ◽

Michael R. Rickels ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Insulin Sensitivity ◽

Beta Cell Function ◽

Cell Function ◽

Cross Sectional ◽

Sectional Analysis ◽

Electrocardiographic Abnormalities

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Association between plasma homocysteine levels and pancreatic islet beta-cell function in the patients with type 2 diabetes mellitus: a cross-sectional study from China

Annals of Palliative Medicine ◽

10.21037/apm-21-1671 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Xinlu Yuan ◽

Sheng Ding ◽

Ligang Zhou ◽

Song Wen ◽

Anqing Du ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Beta Cell Function ◽

Cell Function ◽

Cross Sectional Study ◽

Plasma Homocysteine ◽

Sectional Study ◽

Cross Sectional ◽

Pancreatic Islet Beta Cell

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We are Family

Californian Journal of Health Promotion ◽

10.32398/cjhp.v8i1.2034 ◽

2010 ◽

Vol 8 (1) ◽

pp. 88-97 ◽

Cited By ~ 4

Author(s):

Alexander Omolafe ◽

Michele Mouttapa ◽

Shari McMahan ◽

Sora Park Tanjasiri

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Family History ◽

African Americans ◽

Positive Family History ◽

Self Report ◽

Cross Sectional ◽

History Of

This cross-sectional study sought to describe an association between family history of type-2 diabetes and the awareness of risk factors, perceived threat and physical activity levels in African Americans. With a prevalence of 11.8%, African Americans remain disproportionately affected by the epidemic of diabetes. A risk factor that cannot be modified, but is important and closely linked with diabetes expression, family history, can be a considerable tool in promoting behavior change and reducing the risk of developing the condition in African Americans. A self-report questionnaire was administered to 133 church going African Americans, with 55 of them with a positive family history of type-2 diabetes (41.4%) and 78 (58.6%) without. None of the participants had been previously been diagnosed with type-2 diabetes. The results from the study indicated that African Americans with positive family history had a greater knowledge of risk factors, were more likely to indicate that their concern about the disease influences their eating habits and physical activity, and engaged in significantly more physical activity than those with no family history.

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Green Space Exposure Association with Type 2 Diabetes Mellitus, Physical Activity, and Obesity: A Systematic Review

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010097 ◽

2020 ◽

Vol 18 (1) ◽

pp. 97

Author(s):

Felipe De la Fuente ◽

María Angélica Saldías ◽

Camila Cubillos ◽

Gabriela Mery ◽

Daniela Carvajal ◽

...

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Risk Factors ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Data Extraction ◽

Green Spaces ◽

Cross Sectional

Type 2 diabetes mellitus (T2DM) is a public health challenge that must be addressed considering the large number of risk factors involved in its appearance. Some environmental risk factors are currently described as predictors of diabetes, with access to green spaces being an element to consider in urban settings. This review aims to study the association between exposure to green spaces and outcomes such as diabetes, obesity, and physical activity in the general population. A systematic review was carried out using the PubMed, Embase, and LILACS databases and other sources. The search strategy was carried out from October 2019 to October 2020. Cross-sectional and cohort studies were included. The article selection was made by a pair of reviewers, and data extraction was carried out using a data extraction sheet. The quality assessment of the included studies was carried out using a validated tool. Finally, 19 scientific articles were included in this review. Evidence supports that people and communities exposed to green spaces, especially in their neighborhood, reduce the risk of T2DM and reduce the risk of being obese and increase the likelihood of physical activity. The onset of T2DM can be moderated by using green spaces, improving physical activity levels, and reducing the risk of being overweight and obese.

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CKD and CKDu in northern Peru: a cross-sectional analysis under the DEGREE protocol

BMC Nephrology ◽

10.1186/s12882-021-02239-8 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Andrea Ruiz-Alejos ◽

Ben Caplin ◽

J. Jaime Miranda ◽

Neil Pearce ◽

Antonio Bernabé-Ortiz

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Activity Levels ◽

Cross Sectional ◽

Heavy Proteinuria ◽

Factors Associated ◽

Physical Activity Levels ◽

Northern Peru

Abstract Background This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e., work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e., smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1–2.5%) had an eGFR < 60 mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4–1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

10.21203/rs.3.rs-68853/v1 ◽

2020 ◽

Author(s):

Andrea O. Ruiz-Alejos ◽

Ben Caplin ◽

J. Jaime Miranda ◽

Neil Pearce ◽

Antonio Bernabé-Ortiz

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Activity Levels ◽

Cross Sectional ◽

Heavy Proteinuria ◽

Factors Associated ◽

Physical Activity Levels ◽

Northern Peru

Abstract Aims: This study estimated the prevalence of low eGFR in those without known hypertension, T2DM or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru. Methods: A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤ 60 mL/min/1.7 m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e. work in agriculture or sugarcane, water source, heat, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e. smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others). Results: A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% − 2.5%) had an eGFR < 60 mL/min/1.7 m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% − 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18–3.34), hypertension (OR = 2.07; 1.26–3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18–3.27) were factors associated with low eGFR. Conclusions: A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

10.21203/rs.3.rs-68853/v2 ◽

2020 ◽

Author(s):

Andrea O. Ruiz-Alejos ◽

Ben Caplin ◽

J. Jaime Miranda ◽

Neil Pearce ◽

Antonio Bernabé-Ortiz

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Activity Levels ◽

Cross Sectional ◽

Heavy Proteinuria ◽

Factors Associated ◽

Physical Activity Levels ◽

Northern Peru

Abstract Background:This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru.Methods:A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e. work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e. smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others).Results:A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% - 2.5%) had an eGFR <60mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% - 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18 – 3.34), hypertension (OR = 2.07; 1.26 – 3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18 – 3.27) were factors associated with low eGFR.Conclusions:A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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CKD and CKDu in Northern Peru: a cross-sectional analysis under the DEGREE protocol

10.21203/rs.3.rs-68853/v3 ◽

2021 ◽

Author(s):

Andrea O. Ruiz-Alejos ◽

Ben Caplin ◽

J. Jaime Miranda ◽

Neil Pearce ◽

Antonio Bernabé-Ortiz

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Type 2 Diabetes ◽

Activity Levels ◽

Cross Sectional ◽

Heavy Proteinuria ◽

Factors Associated ◽

Physical Activity Levels ◽

Northern Peru

Abstract Background: This study estimated the prevalence and risk factors for decreased estimated glomerular filtration rate (eGFR) in those without known hypertension, type 2 diabetes mellitus, or heavy proteinuria as a surrogate marker for chronic kidney disease of unknown cause (CKDu) among adults in the North of Peru.Methods:A cross-sectional study was conducted following the Disadvantaged Populations eGFR Epidemiology (DEGREE) Study protocol. Low eGFR was defined based on a single eGFR ≤60 mL/min/1.7m2 estimated using the CKD-EPI equation. Environmental conditions related to CKDu (i.e., work in agriculture or sugarcane, water source, heat intolerance, and pesticide exposure) were evaluated, in addition to traditional risk factors for CKD (i.e., smoking, heavy drinking, physical activity, hypertension, type 2 diabetes mellitus, urolithiasis, among others).Results:A total of 1514 subjects were included in the study, mean age 45.1 (SD: 16.4), and 55.2% were females. Overall, only 26 cases (1.7%; 95%CI: 1.1% - 2.5%) had an eGFR <60mL/min/1.7m2 compatible with CKD definition; when those with hypertension and type-2 diabetes or heavy proteinuria were excluded, according to the DEGREE protocol, the estimate fell to 0.9% (95%CI: 0.4% - 1.5%). Low physical activity levels (OR = 1.99; 95%CI: 1.18 – 3.34), hypertension (OR = 2.07; 1.26 – 3.41), and urolithiasis (OR = 1.97; 95%CI: 1.18 – 3.27) were factors associated with low eGFR.Conclusions: A low population-based prevalence of low eGFR (as a surrogate for CKDu), both in rural and urban settings areas, in the Northern Peru, was found. Low physical activity levels, hypertension and urolithiasis were factors associated with low eGFR. Interventions to prevent CKD cases may be focused on well-known CV risk factors and urolithiasis.

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