A history of diabetes but not hyperglycaemia during exacerbation of obstructive lung disease has impact on long-term mortality: a prospective, observational cohort study

IntroductionThe Its Not JUST Idiopathic pulmonary fibrosis Study (INJUSTIS) is a multicentre, prospective, observational cohort study. The aims of this study are to identify genetic, serum and other biomarkers that may identify specific molecular mechanisms, reflecting disease endotypes that are shared among patients with progressive pulmonary fibrosis regardless of aetiology. Furthermore, it is anticipated that these biomarkers will help predict fibrotic activity that may identify patterns of disease behaviour with greater accuracy than current clinical phenotyping.Methods and analysis200 participants with the multidisciplinary team confirmed fibrotic lung disease (50 each of rheumatoid-interstitial lung disease (ILD), asbestosis, chronic hypersensitivity pneumonitis and unclassifiable ILD) and 50 idiopathic pulmonary fibrosis participants, recruited as positive controls, will be followed up for 2 years. Participants will have blood samples, lung function tests, quality of life questionnaires and a subgroup will be offered bronchoscopy. Participants will also be given the option of undertaking blinded home handheld spirometry for the first 3 months of the study. The primary end point will be identification of a biomarker that predicts disease progression, defined as 10% relative change in forced vital capacity (FVC) or death at 12 months.Ethics and disseminationThe trial has received ethical approval from the National Research Ethics Committee Nottingham (18/EM/0139). All participants must provide written informed consent. The trial will be overseen by the INJUSTIS steering group that will include a patient representative, and an independent chairperson. The results from this study will be submitted for publication in peer-reviewed journals and disseminated at regional and national conferences.Trial registration numberNCT03670576.

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Long-term prognosis of chronic cough: a prospective, observational cohort study

BMC Pulmonary Medicine ◽

10.1186/s12890-017-0496-1 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 13

Author(s):

Heikki O. Koskela ◽

Anne M. Lätti ◽

Minna K. Purokivi

Keyword(s):

Cohort Study ◽

Chronic Cough ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Observational Cohort ◽

Long Term Prognosis

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P124. A Non-surgical Approach to the Management of Patients with Lumbar Radiculopathy Secondary to Disc Herniation: A Prospective Observational Cohort Study with Long-term Follow-up

The Spine Journal ◽

10.1016/j.spinee.2008.06.766 ◽

2008 ◽

Vol 8 (5) ◽

pp. 161S ◽

Cited By ~ 1

Author(s):

Donald R. Murphy ◽

Eric L. Hurwitz ◽

Ericka E. McGovern

Keyword(s):

Cohort Study ◽

Disc Herniation ◽

Surgical Approach ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Lumbar Radiculopathy ◽

Long Term Follow Up ◽

Observational Cohort

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Long-term follow-up for Psychological stRess in Intensive CarE (PRICE) survivors: study protocol for a multicentre, prospective observational cohort study in Australian intensive care units

BMJ Open ◽

10.1136/bmjopen-2018-023310 ◽

2019 ◽

Vol 9 (1) ◽

pp. e023310

Author(s):

Sumeet Rai ◽

Rhonda Brown ◽

Frank van Haren ◽

Teresa Neeman ◽

Arvind Rajamani ◽

...

Keyword(s):

Cohort Study ◽

Intensive Care ◽

Family Members ◽

Psychological Outcomes ◽

Observational Cohort Study ◽

Screening Tools ◽

Prospective Observational Cohort Study ◽

Observational Cohort

IntroductionThere are little published data on the long-term psychological outcomes in intensive care unit (ICU) survivors and their family members in Australian ICUs. In addition, there is scant literature evaluating the effects of psychological morbidity in intensive care survivors on their family members. The aims of this study are to describe and compare the long-term psychological outcomes of intubated and non-intubated ICU survivors and their family members in an Australian ICU setting.Methods and analysisThis will be a prospective observational cohort study across four ICUs in Australia. The study aims to recruit 150 (75 intubated and 75 non-intubated) adult ICU survivors and 150 family members of the survivors from 2015 to 2018. Long-term psychological outcomes and effects on health-related quality of life (HRQoL) will be evaluated at 3 and 12 months follow-up using validated and published screening tools. The primary objective is to compare the prevalence of affective symptoms in intubated and non-intubated survivors of intensive care and their families and its effects on HRQoL. The secondary objective is to explore dyadic relations of psychological outcomes in patients and their family members.Ethics and disseminationThe study has been approved by the relevant human research ethics committees (HREC) of Australian Capital Territory (ACT) Health (ETH.11.14.315), New South Wales (HREC/16/HNE/64), South Australia (HREC/15/RAH/346). The results of this study will be published in a peer-reviewed medical journal and presented to the local intensive care community and other stakeholders.Trial registration numberACTRN12615000880549; Pre-results.

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The long-term postoperative trajectory of geriatric patients admitted for a hip fracture: A prospective observational cohort study

Orthopaedics & Traumatology Surgery & Research ◽

10.1016/j.otsr.2019.11.017 ◽

2020 ◽

Vol 106 (4) ◽

pp. 621-625 ◽

Cited By ~ 1

Author(s):

Philippe Beauchamp-Chalifour ◽

Etienne L. Belzile ◽

Louis-Charles Racine ◽

Marie-Pier Nolet ◽

Stéphane Lemire ◽

...

Keyword(s):

Cohort Study ◽

Hip Fracture ◽

Geriatric Patients ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Observational Cohort

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Prospective observational cohort study of early recurrent TIA

Neurology ◽

10.1212/wnl.0000000000010317 ◽

2020 ◽

Vol 95 (12) ◽

pp. e1733-e1744

Author(s):

Matteo Foschi ◽

Lucia Pavolucci ◽

Francesca Rondelli ◽

Luca Spinardi ◽

Elisabetta Favaretto ◽

...

Keyword(s):

Cohort Study ◽

Observational Cohort Study ◽

Large Artery ◽

Prospective Observational Cohort Study ◽

Stroke Incidence ◽

Long Term Outcome ◽

Coronary Syndrome ◽

Observational Cohort

ObjectivesTo evaluate the frequency, clinical and etiologic features, and short- and long-term outcomes of early recurrent TIA.MethodsThis prospective observational cohort study enrolled all consecutive patients with TIA referred to our emergency department and diagnosed by a vascular neurologist. Expedited assessment and best secondary prevention were performed within 24 hours. Primary endpoints were stroke and a composite outcome including stroke, acute coronary syndrome, and vascular death at 3, 12, and, for a subset of patients, 60 months; secondary outcomes were TIA relapse, cerebral hemorrhage, new-onset atrial fibrillation, and death resulting from other causes. Concordance between index TIA and subsequent stroke etiologies was also evaluated.ResultsA total of 1,035 patients (822 with a single TIA, 213 with recurrent TIA = 21%) were enrolled from August 2010 to December 2017. Capsular warning syndrome and large artery atherosclerosis showed the strongest relationship with early recurrent TIA. The risk of stroke was significantly higher in the early recurrent TIA subgroup at each follow-up, and most stroke episodes occurred within 48 hours of index TIA. TIAs with lesion, dysarthria, and leukoaraiosis were the 3- and 12-month independent predictors of stroke incidence after early recurrent TIA subgroup. Index TIA and subsequent stroke etiologies showed substantial concordance. An ABCD3 score >6 predicted a higher risk of stroke recurrence over the entire follow-up.ConclusionsOur study evaluated long-term outcome after early recurrent TIA. Our observations support the importance of promptly detecting and treating patients with early recurrent TIAs to reduce the high early and long-term risk of poor clinical outcomes.

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