scholarly journals Post-traumatic growth and its relationship to quality of life up to 9 years after liver transplantation: a cross-sectional study in Spain

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017455 ◽  
Author(s):  
María Ángeles Pérez-San-Gregorio ◽  
Agustín Martín-Rodríguez ◽  
Mercedes Borda-Mas ◽  
María Luisa Avargues-Navarro ◽  
José Pérez-Bernal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
General Population ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Cross Sectional ◽  
Post Traumatic Growth ◽  
Post Traumatic ◽  
Liver Transplant Recipients

ObjectiveLittle is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG between liver transplant recipients and their caregivers.DesignCross-sectional case–control study.SettingUniversity Hospital in Spain.Participants240 adult liver transplant recipients who had undergone only one transplantation, with no severe mental disease, were the participants of the study. Specific additional analyses were conducted on the subset of 216 participants for whom caregiver data were available. Moreover, results were compared with a previously recruited general population sample.Outcome measuresAll participants completed the Posttraumatic Growth Inventory, and recipients also filled in the 12-Item Short-Form Health Survey. Relevant sociodemographic and clinical parameters were also assessed.ResultsIn the sample of 240 recipients, longer time since transplantation (>9 years) was associated with more pain symptoms (p=0.026). Regardless of duration, recipients showed lower scores on most quality of life dimensions than the general population. However, high PTG was associated with a significantly higher score on the vitality quality of life dimension (p=0.021). In recipients with high PTG, specific quality of life dimensions, such as bodily pain (p=0.307), vitality (p=0.890) and mental health (p=0.353), even equalled scores in the general population, whereas scores on general health surpassed them (p=0.006). Furthermore, liver transplant recipients (n=216) compared with their caregivers showed higher total PTG (p<0.001) and higher scores on the subscales relating to others (p<0.001), new possibilities (p<0.001) and appreciation of life (p<0.001).ConclusionsOur findings highlight the protective role of PTG in the long-term outcome of liver transplant recipients. Future studies should analyse and develop psychosocial interventions to strengthen PTG in transplant recipients and their caregivers.

scholarly journals Quality of Life in Liver Transplant Recipients: A Retrospective Study

2020 ◽  
Vol 17 (11) ◽  
pp. 3809
Author(s):  
Rosario Girgenti ◽  
Alessandro Tropea ◽  
Maria Antonina Buttafarro ◽  
Rosalia Ragusa ◽  
Martina Ammirata
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Deceased Donor ◽  
Transplant Recipients ◽  
Therapeutic Adherence ◽  
The Individual ◽  
End Stage ◽  
Liver Transplant Recipients

Background: This study aims to investigate the quality of life and the therapeutic compliance of the patients who received a liver transplant, from a living or deceased donor, at IRCCS ISMETT in the last three years. Liver transplantation is an effective therapeutic strategy for patients with end-stage liver failure. The quality of life (QOL) of liver disease patients is placed under considerable stress due to the debilitating clinical conditions and related issues experienced in everyday life by these individuals. The concept of QOL is being increasingly used to define the individual perception of health, including physical, mental, and social wellbeing. The success of a liver transplant should therefore be intended not only in terms of survival, but also of recovery of a satisfying quality of life. For this reason, our liver transplant recipients are closely monitored and supported from a psychological standpoint. This is done to monitor their ability to adapt to and comply with their clinical condition and to verify their gradual resumption of their path of life Methods: We retrospectively analyzed data collected by the IRCCS ISMETT Clinical Psychology Service during routine psychological follow-up of liver transplant recipients. Data refer to 82 patients who received a liver transplant between January 2017 and September 2019 and describe their QOL and therapeutic adherence. The obtained results were compared with the main studies on this issue available in literature. Results: Ninety-four percent of liver transplant recipients reported high mean scores of quality of life and therapeutic adherence 28% of patients reported at least one persistent annoying symptom after transplantation, although in some cases this did not affect the overall QOL. The results also refer to patients with a pre-transplant diagnosis of alcohol-related cirrhosis, who confirm their complete abstinence from alcohol. Conclusions: Our results confirm the efficacy of the liver transplantation to achieve of a good QOL. Furthermore, these patients seem to maintain high therapeutic adherence, thus ensuring a good outcome of the care received during the transplantation process.

An Exploratory Investigation of Quality of Life in Adult Liver Transplant Recipients

2005 ◽  
Vol 15 (4) ◽  
pp. 392-396
Author(s):  
Kathy B. Bean
Keyword(s):  
Quality Of Life ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Policy Makers ◽  
Survey Tool ◽  
Face To Face ◽  
Exploratory Investigation ◽  
Liver Transplant Recipients

Quality of life is an important outcome indicator of experiences associated with liver transplantation. Unfortunately, quality of life has been defined in many different ways, causing confusion and misconceptions among practitioners, researchers, policy makers, and patients. This exploratory qualitative study was initiated to gain greater understanding regarding the adult transplant recipients' experiences with liver transplantation in order to direct future studies with this population and to assist in selection of a relevant quality of life survey tool for quantitative investigation. Twelve informants (7 women, 5 men) shared their experiences in face-to-face interviews conducted by the researcher. Analysis of these interviews reveals the importance of physiologic, psychological, social, spiritual, family, and socioeconomic aspects of quality of life for liver transplant recipients.

scholarly journals Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ahad Eshraghian ◽  
Elham Moasser ◽  
Negar Azarpira ◽  
Mohammad Reza Fattahi ◽  
Saman Nikeghbalian ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Hepatic Steatosis ◽  
Cross Sectional Study ◽  
Genetic Variations ◽  
Transplant Recipients ◽  
Sectional Study ◽  
Proprotein Convertase ◽  
Cross Sectional ◽  
Liver Transplant Recipients

Abstract Background Genetic abnormalities might have important role in pathogenesis of hepatic steatosis after liver transplantation. We aimed to investigate association between genetic variations in transmembrane 6 superfamily member 2 (TM6SF2) rs58542926, proprotein convertase subtilisin/kexin type 9 (PCSK9) rs505151 and proprotein convertase subtilisin/kexin type 7 (PCSK7) rs2277287 with hepatic steatosis in liver transplant recipients. Methods In a cross-sectional study, adult (> 18 years) liver transplant recipients who were referred for their routine post-transplant follow-up between June 2018 and September 2018 were included in the study. Hepatic steatosis in transplant recipients was assessed by controlled attenuation parameter (CAP). Polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) was used to study TM6SF2 rs58542926, PCSK7 rs2277287 and PCSK9 rs505151 genotypes. Results 107 liver transplant recipients were included. There was no association between different genotypes of PCSK9 rs505151 and PCSK7 rs2277287 with hepatic steatosis in liver transplant recipients (P value > 0.05). The presence of TT genotype of TM6SF2 rs58542926 was higher in patients with hepatic steatosis measured by CAP after liver transplantation. In patients with moderate and severe hepatic steatosis (grade 2 and 3 steatosis), AG + GG genotypes of PCSK9 rs505151 were more prevalent than AA genotype (OR 8.667; 95% CI 1.841–40.879; P value = 0.004) compared to patients with mild steatosis (grade 1). In multivariate regression model, AG + GG genotypes of PCSK9 rs505151 were associated with moderate and severe steatosis in liver transplant recipients (OR 5.747; 95% CI 1.086–30.303; P value = 0.040). Conclusions Genetic variations in TM6SF2 rs58542926 and PCSK9 rs505151 might be associated with hepatic steatosis in liver transplant recipients.

scholarly journals Impact of biliary complications on quality of life in live-donor liver transplant recipients

2021 ◽  
Vol 13 (10) ◽  
pp. 1405-1416
Author(s):  
Reginia Nabil Guirguis ◽  
Ehab Hasan Nashaat ◽  
Azza Emam Yassin ◽  
Wesam Ahmed Ibrahim ◽  
Shereen A Saleh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Transplant ◽  
Live Donor ◽  
Transplant Recipients ◽  
Donor Liver ◽  
Live Donor Liver Transplant ◽  
Live Donor Liver ◽  
Donor Liver Transplant ◽  
Liver Transplant Recipients
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