scholarly journals Protocol for the avatar acceptability study: a multiperspective cross-sectional study evaluating the acceptability of using patient-derived xenografts to guide personalised cancer care in Australia and New Zealand

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e024064 ◽  
Author(s):  
Claire E Wakefield ◽  
Emma L Doolan ◽  
Joanna E Fardell ◽  
Christina Signorelli ◽  
Veronica F Quinn ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Cancer Care ◽  
New Technologies ◽  
Cross Sectional Study ◽  
Decisional Balance ◽  
Local Health ◽  
Sectional Study ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Advantages And Disadvantages

IntroductionPatient-derived xenografts (PDXs) have the potential to transform personalised cancer care, however, little is known about the acceptability of using PDXs to guide treatment decision-making. Given that patient and community preferences can influence satisfaction with care as well as the success of new technologies, we will evaluate the acceptability of PDXs in individuals affected by cancer and community comparisons.Methods and analysisThis comparative cross-sectional study will recruit 323 individuals affected by cancer (cancer survivors (of childhood or adult cancer) and parents of childhood cancer survivors) and 323 community comparisons (adults and parents). We will collect data via structured interviews and questionnaires. To determine the acceptability of PDXs, we will assess five domains: willingness to use PDXs when/if diagnosed with cancer, perceived advantages and disadvantages of PDXs, maximum acceptable out-of-pocket costs per patient, maximum acceptable turnaround time to receive results and maximum acceptable number of mice sacrificed per patient. The primary endpoint will be participants’ decisional balance ratio (calculated as participants’ advantages ratings divided by perceived disadvantages ratings).Ethics and disseminationThe study protocol has been approved by the South Eastern Sydney Local Health District Human Research Ethics Committee (HREC:12/173) and UNSW Sydney (HC15773). The results will be disseminated in peer-reviewed journals and at scientific conferences. A lay summary will be published on the Behavioural Sciences Unit website.

scholarly journals Healthcare utilisation, cancer screening and potential barriers to accessing cancer care in rural South West Nigeria: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e040352
Author(s):  
Avinash Sharma ◽  
Olusegun Isaac Alatise ◽  
Kelli O'Connell ◽  
Samson Gbenga Ogunleye ◽  
Adewale Abdulwasiu Aderounmu ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Cancer Care ◽  
Healthcare Utilisation ◽  
Cross Sectional Study ◽  
Personal Income ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Potential Barriers ◽  
South West

Background/aimsCancer burden is predicted to double by 2030 in sub-Saharan Africa; access to healthcare services for cancer management is a priority in the region. In Nigeria, National Cancer Control Plan aims to ensure >50% cancer screening of eligible populations by 2022 for all Nigerians. We describe healthcare utilisation, cancer screening activities and potential barriers to accessing cancer care within an understudied rural community-based adult population in South West Nigeria.MethodsIn April 2018, we conducted a cross-sectional study of community-based adults (>18 years) ~130 km east of Ibadan, 250 km from Lagos in Osun State, South West Nigeria. Participants completed a face-to-face survey in local dialect. We used a questionnaire to assess demographics, health status, income, medical expenditures, doctor visits and cancer screening history.ResultsWe enrolled 346 individuals: with median age of 52 years and 75% women. Of the entire cohort, 4% had medical insurance. 46% reported a major medical cost in the last year. Cancer screening activities were infrequent in eligible participants: 1.5% reported having had cervical cancer screening, 3.3% mammogram and 5% colonoscopy screening. Cancer screening assessment was less frequent in those with less income and lower education levels. Using a multivariable logistic regression model including personal income, insurance status and education, higher personal income was associated with more cancer screening activity (OR 2.7, 95% CI 1.3 to 5.7, p<0.01). Despite this, most individuals had contact with a primary healthcare doctor (52% in the last year), and over 70% access to radio and TV suggesting the opportunity to expand community-based screening interventions and awareness exists.ConclusionsDespite national increases in cancer cases, we highlight a deficiency in cancer screening and universal healthcare coverage within a community-based adult Nigerian population. Subject to availability of governmental resources, increasing financial risk protection, awareness and targeted resource allocation may help expand access in Nigeria.

Wide variability in colorectal cancer screening uptake by general practitioner: Cross-sectional study

2021 ◽  
pp. 096914132110357
Author(s):  
Cecilia Acuti Martellucci ◽  
Maria E Flacco ◽  
Margherita Morettini ◽  
Giusi Giacomini ◽  
Matthew Palmer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Geographical Area ◽  
Central Italy ◽  
Cross Sectional Study ◽  
Local Health ◽  
Sectional Study ◽  
Cross Sectional ◽  
Crc Screening ◽  
Screening Uptake

Objectives Despite several interventions, colorectal cancer (CRC) screening uptake remains below acceptable levels in Italy. Among the potential determinants of screening uptake, only a few studies analysed the role of general practitioners (GPs). The aim was to evaluate the variation in screening uptake of the clusters of subjects assisted by single GPs. Setting Ancona province, Central Italy. Methods Cross-sectional study, including all residents aged 50–69 years, who were offered the public screening programme with biannual faecal immunochemical tests. Demographic (of all GPs) and screening data (of all eligible residents) for years 2018–2019 were collected from the official electronic datasets of the Ancona Local Health Unit. The potential predictors of acceptable screening uptake, including GP's gender, age, and number of registered subjects, were evaluated using random-effect logistic regression, with geographical area as the cluster unit. Results The final sample consisted of 332 GP clusters, including 120,178 eligible subjects. The overall province uptake was 38.0% ± 10.7%. The uptake was lower than 30% in one-fifth of the GP clusters, and higher than 45% in another fifth. At multivariable analysis, the significant predictors of uptake were younger GP age ( p = 0.010) and lower number of registered subjects ( p < 0.001). None of the GP clusters with 500 subjects or more showed an uptake ≥45%. Conclusions The wide variation across GPs suggests they might substantially influence screening uptake, highlighting a potential need to increase their commitment to CRC screening. Further research is needed to confirm the role of the number of registered subjects.

scholarly journals Use of psychotropic medications by caregivers of elderly patients with dementia: is this a sign of caregiver burden?

2012 ◽  
Vol 70 (3) ◽  
pp. 169-174 ◽  
Author(s):  
Einstein Francisco Camargos ◽  
Andrea Brígida Souza ◽  
Aline Silva Nascimento ◽  
Alessandra Cicari Morais-e-Silva ◽  
Juliana Lima Quintas ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Caregiver Burden ◽  
Psychotropic Drugs ◽  
Cross Sectional Study ◽  
Psychotropic Medications ◽  
Sectional Study ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Sleeping Pills

This study evaluated the consumption of psychotropic medications by caregivers of elderly patients with or without dementia. This was a cross-sectional study conducted at all geriatric units in Brasília, Brazil, during a two-month period. Structured interviews were performed with 311 caregivers of people with or without dementia and they completed questionnaires. Among the caregivers, 196 (63%) were caregivers of patients with dementia and 115 (37%) were caregivers of patients without dementia. Forty-four caregivers (14.1%) were taking psychotropic drugs (benzodiazepines or antidepressants), and this usage was more frequent among caregivers of patients with dementia (p<0.01). Twenty-two caregivers of patients with dementia (11.4%) had used sleeping pills after beginning care, compared with only five (4.3%) caregivers of patients without dementia (p<0.01). In conclusion, this study found that caregivers of patients with dementia took psychotropic drugs (benzodiazepines and antidepressants) more frequently than the ones of patients without dementia.

Healthy behaviors are associated with positive outcomes for cancer survivors with ostomies: a cross-sectional study

2020 ◽  
Author(s):  
Julia Mo ◽  
Cynthia A. Thomson ◽  
Virginia Sun ◽  
Christopher S. Wendel ◽  
Mark C. Hornbrook ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Cross Sectional Study ◽  
Positive Outcomes ◽  
Sectional Study ◽  
Cross Sectional ◽  
Healthy Behaviors

scholarly journals Perbedaan Proporsi Gangguan Depresi dan Gangguan Cemas Antara Mahasiswa Preklinik dan Klinik

2017 ◽  
Vol 6 (3) ◽  
pp. 146
Author(s):  
Yoan Chou ◽  
Dharmady Agus ◽  
Dwi Jani Juliawati
Keyword(s):  
Anxiety Disorder ◽  
Medical Students ◽  
Depressive Disorder ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Structured Interviews ◽  
Cross Sectional ◽  
Icd 10

Background: Medical education is full of burden and pressure, so that medical students are prone to get depressive disorder and anxiety disorder. These have been proven by several researches conducted in the faculties of medicine from abroad as well as in Indonesia. Medical students, either preclinical or clinical, need to face many obstacles, but clinical students have more demands than preclinical students and they are directly responsible for patient safety. The more demands of the clinical students made them prone to have more depressive and anxiety disorder.Method: This research was conducted as a cross-sectional study on 200 students on Atma Jaya Medicine Faculty by choosing 100 pre-clinical and clinical students with simple random sampling. Data were collected with structured interviews by using MINI ICD-10 instrument to determine the depressive and anxiety disorder.Results: There were significant differences between the proportion of depressive disorder and anxiety disorder among preclinical and clinical students in FKUAJ 2015 (p = 0.044 and p = 0.048). The proportion of depressive disorder and anxiety disorder in clinical students are higher than preclinical students (29% vs. 17% and 38% vs. 25%).Conclusions: Clinical students are more prone to get depressive disorder 1,99 times and anxiety disorder 1,84 times than preclinical students FKUAJ year 2015 

Modality-specific exercise guidelines and quality of life in kidney cancer survivors: A cross-sectional study

2018 ◽  
Vol 27 (10) ◽  
pp. 2419-2426 ◽  
Author(s):  
Linda Trinh ◽  
Dominick A. Strom ◽  
Jaime N. Wong ◽  
Kerry S. Courneya
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Kidney Cancer ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Specific Exercise ◽  
Cross Sectional ◽  
Exercise Guidelines
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