scholarly journals Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e043658
Author(s):  
Maria Truesdale ◽  
Craig Melville ◽  
Fiona Barlow ◽  
Kirsty Dunn ◽  
Angela Henderson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intellectual Disabilities ◽  
Meta Analysis ◽  
Analysis Data ◽  
Quality Healthcare ◽  
Premature Deaths ◽  
Statistical Heterogeneity ◽  
Health Initiatives ◽  
People With Intellectual Disabilities ◽  
Associated Risk Factors

ObjectiveTo review and synthesise evidence on rates of respiratory-associated deaths and associated risk factors in the intellectual disability population.DesignSystematic review and meta-analysis.Data sourcesEmbase, CINAHL, ISI Web of Science (all databases including Medline) and PsychINFO were searched for studies published between 1st January 1985 and 27th April 2020 and examined study and outcome quality. Reference lists and Google Scholar were also hand searched.ResultsWe identified 2295 studies, 17 were included in the narrative synthesis and 10 studies (11 cohorts) in the meta-analysis. Data from 90 302 people with intellectual disabilities and 13 808 deaths from all causes in people with intellectual disabilities were extracted. Significantly higher rates of respiratory-associated deaths were found among people with intellectual disabilities (standardised mortality ratio(SMR): 10.86 (95% CI: 5.32 to 22.18, p<0.001) compared with those in the general population, lesser rates for adults with ID (SMR: 6.53 (95% CI: 4.29 to 9.96, p<0.001); and relatively high rates from pneumonia 26.65 (95% CI: 5.63 to 126.24, p<0.001). The overall statistical heterogeneity was I2=99.0%.ConclusionPremature deaths due to respiratory disorders are potentially avoidable with improved public health initiatives and equitable access to quality healthcare. Further research should focus on developing prognostic guidance and validated tools for clinical practice to mitigate risks of respiratory-associated deaths.PROSPERO registration numberCRD42020180479.

scholarly journals Preterm birth and its associated factors in Ethiopia: a systematic review and meta- analysis

2021 ◽  
Vol 21 (3) ◽  
pp. 1321-1333
Author(s):  
Fikadu Waltengus Sendeku ◽  
Fentahun Yenealem Beyene ◽  
Azimeraw Arega Tesfu ◽  
Simachew Animen Bante ◽  
Getnet Gedefaw Azeze
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Preterm Birth ◽  
Meta Analysis ◽  
Preterm Births ◽  
Pooled Analysis ◽  
Health Concern ◽  
Middle Income ◽  
Quality Healthcare ◽  
Associated Risk Factors

Background: Preterm birth is a public health concern globally. In low- and middle-income countries, like Ethiopia, preterm birth is under reported and underestimated. Therefore, this systematic review and meta-analysis assessed the pooled preva- lence and associated risk factors for preterm birth in Ethiopia. Methods: In this review the databases used were PubMed, Google scholar, EMBASE, HINARI and African journal online. Publication bias was checked using a funnel plot and Eggers test. Results: A total of 30 studies were included in this systematic review and meta-analysis. The overall pooled prevalence of preterm birth in Ethiopia was 11.4% (95% CI; 9.04, 13.76). On pooled analysis, preterm birth was associated with pregnan- cy-induced hypertension being HIV-positive, premature rupture of membrane, rural residence, the mother having a history of abortion, multiple pregnancies, and anemia during pregnancy. Conclusion: The national prevalence of preterm birth in Ethiopia was low. Early identifying those pregnant women who are at risk of the above determinants and proving quality healthcare and counsel them how to prevent preterm births, which decrease the rate of preterm birth and its consequences. So, both governmental and non-governmental health sectors work on the minimization of these risk factors. Keywords: Prevalence; pre-term birth; determinants; systematic review; meta-analysis; Ethiopia.

scholarly journals Factors leading to effective social participation promotion interventions for people with intellectual disability: a protocol for a systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Andrés Aparicio ◽  
Paulina Arango ◽  
Rosario Espinoza ◽  
Vicente Villate ◽  
Marcela Tenorio
Keyword(s):  
Systematic Review ◽  
Intellectual Disability ◽  
Intellectual Disabilities ◽  
Social Participation ◽  
Meta Analysis ◽  
Grey Literature ◽  
Well Being ◽  
Controlled Trials ◽  
Decision Making Processes ◽  
People With Intellectual Disabilities

Abstract Background People with intellectual disabilities have been historically excluded from decision-making processes. Previous literature indicates that increasing social participation may be an effective way to address this exclusion, but no systematic review of interventions designed to increase social participation of people with intellectual disabilities have been conducted. This study aims to identify and organize the factors associated with interventions that increase the social participation of people with intellectual disabilities and to provide a set of best of practices for future interventions. Methods/design The databases Web of Science, Scopus, LILACS, and PubMed will be searched for articles from January 2004 onwards; grey literature search will be identified through searching additional databases (such as Google Scholar and EBSCO databases). Randomized controlled trials, nonrandomized controlled trials, and controlled pre–post studies will be included. Noncontrolled pre–post studies will also be included. Observational or qualitative studies will be excluded. The primary outcomes are measures of social participation. Secondary outcomes include measures of well-being, stigma, knowledge about rights, and advocacy processes. Two reviewers will independently screen articles, extract relevant data, and assess the quality of the studies. We will provide a meta-analysis of included studies if possible, or a quantitative narrative synthesis otherwise. Discussion This systematic review will add to our understanding of effective social participation interventions for people with intellectual disability. It will allow us to identify and organize which factors lead to an increase in social participation and help us define a set of best practices to be followed by future interventions. Systematic review registration PROSPERO CRD42020189093

scholarly journals Exercise interventions to improve balance for young people with intellectual disabilities: a systematic review and meta‐analysis

2018 ◽  
Vol 61 (4) ◽  
pp. 406-418 ◽  
Author(s):  
Christophe Maïano ◽  
Olivier Hue ◽  
Alexandre J S Morin ◽  
Geneviève Lepage ◽  
Danielle Tracey ◽  
...  
Keyword(s):  
Systematic Review ◽  
Young People ◽  
Intellectual Disabilities ◽  
Meta Analysis ◽  
Exercise Interventions ◽  
People With Intellectual Disabilities

scholarly journals Factors Leading to the Success of Social Participation Promotion Programs for People with Intellectual Disability: A Protocol for A Systematic Review

2020 ◽  
Author(s):  
Andrés Aparicio ◽  
Paulina Arango ◽  
Rosario Espinoza ◽  
Vicente Villate ◽  
Marcela Tenorio
Keyword(s):  
Systematic Review ◽  
Intellectual Disability ◽  
Intellectual Disabilities ◽  
Social Participation ◽  
Social Inclusion ◽  
Positive Impact ◽  
Meta Analysis ◽  
Grey Literature ◽  
Before And After ◽  
People With Intellectual Disabilities

Abstract Background People with intellectual disabilities have been historically excluded from decision-making processes. Previous literature indicates that social participation may be an effective tool to increase social inclusion, but no systematic review of interventions focused on social participation of people with intellectual disabilities have been conducted. This study aims to identify and organize the factors associated with social participation interventions having a positive impact on social inclusion of people with intellectual disabilities; and to provide a set of best of practices for future interventions. Methods/design This systematic review of the literature will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) recommendations. The databases Web of Science, EBSCO, Scopus, LILACS and PubMed will be searched for articles between January 1 st , 2004 and December 31 st , 2019; a grey literature search will also be conducted. Randomized control trials, nonrandomized control trials, and controlled before and after studies will be included. If necessary, noncontrolled before and after studies will also be included. Observational or qualitative studies will be excluded. The primary outcome is success of intervention. Secondary outcomes include measures of social participation. Two reviewers will independently screen articles, extract relevant data and assess the quality of the studies. Discussion This systematic review will add to our understanding of successful social participation interventions for people with intellectual disability. It will allow us to identify and organize which factors lead to an increase in social participation and help us define a set of best practices to be followed by future interventions. Systematic review registration This protocol is submitted to the PROSPERO registry of the University of York (reference number: 189093).

Effects of diacerein intake on cardiometabolic profiles in type 2 diabetics: a systematic review and meta-analysis of clinical trials.

2020 ◽  
Vol 27 ◽  
Author(s):  
Peyman Nowrouzi-Sohrabi ◽  
Reza Tabrizi ◽  
Mohammad Jalali ◽  
Navid Jamali ◽  
Shahla Rezaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Body Weight ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Cochrane Central Register ◽  
Statistical Heterogeneity

Introduction: A systematic review and meta-analysis of clinical trials was undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2 ) statistic. Data were pooled using random-effect models and weighted mean difference (WMD). Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2 = 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2 = 9.5%) were identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD - 9.00; 95%CI -22.57 to 4.57; P= 0.194; I2 = 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI 0.95 to 1.73; P= 0.569; I2 = 2.2%), body weight (WMD -0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2 = 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2 = 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2 = 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2 = 37.8%). Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of effect was observed for FBS, HOMA-IR, body weight, triglycerides, total-cholesterol, HDL-cholesterol or LDL-cholesterol.

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