scholarly journals Effects of high-load and low-load resistance training in patients with coronary artery disease: rationale and design of a randomised controlled clinical trial

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e051325
Author(s):  
Tim Kambic ◽  
Nejc Šarabon ◽  
Vedran Hadžić ◽  
Mitja Lainscak
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Clinical Community ◽  
Randomised Controlled Clinical Trial ◽  
Registration Number ◽  
Artery Disease ◽  
Randomised Controlled

IntroductionResistance training (RT) combined with aerobic training (AT) enhances the effects of cardiac rehabilitation (CR) in patients with coronary artery disease (CAD). However, it remains to be investigated which type of RT (high loads (HLs) vs low loads (LLs)) is more efficacious in improving exercise performance, cardio-metabolic health and quality of life.Methods and analysisA randomised, controlled, clinical trial will enrol 20 patients with CAD into each of three study arms (total 60 patients): HL-RT (70%–80% of one repetition maximum (1-RM)) combined with AT; LL-RT (30%–40% of 1-RM) combined with AT and AT alone as standard care. Primary outcomes (maximal aerobic capacity, maximal leg isometric strength) will be assessed at baseline and after 36 training sessions. Other outcomes will include acute haemodynamic responses to LL-RT and HL-RT, body composition, physical performance, blood biomarkers (lipids, glucose metabolism, inflammation, growth factors), physical activity and quality of life. The intention-to-treat principle will be used to analyse the data.Ethics and disseminationThe study design and protocol have been approved by the National Medical Ethics Committee of Slovenia (registration number: 0120-573/2019/15). The study will be conducted in accordance with the Declaration of Helsinki. The results of the study will be published as peer-reviewed manuscripts and congress presentations, communicated with patients and the clinical community, and shared through posts on social media. The findings of the study will be disseminated among the national CR clinical community (CR centres, Slovenian association of coronary clubs) with active participation of the patients enrolled in the study. This study will expand our knowledge of RT in combination with AT in CR. We expect to find different effects of HL-RT versus LL-RT, with implications for RT strategies in rehabilitation of patients with CAD.Trial registration numberNCT04638764.

scholarly journals Impact of oral rehabilitation on the quality of life of partially dentate elders in a randomised controlled clinical trial: 2 year follow-up

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0203349 ◽  
Author(s):  
Gerald McKenna ◽  
Patrick Finbarr Allen ◽  
Martina Hayes ◽  
Cristiane DaMata ◽  
Ciaran Moore ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Oral Rehabilitation ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled ◽  
Partially Dentate

HFrEF other treatment: revascularization

ESC CardioMed ◽  
2018 ◽  
pp. 1881-1884
Author(s):  
Eric Velazquez ◽  
Mark C. Petrie
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Coronary Artery Disease ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Common Cause ◽  
Reduced Ejection Fraction ◽  
Artery Disease

Although coronary artery disease is the most common cause of heart failure with reduced ejection fraction (HFrEF), the role of revascularization as a treatment strategy to improve survival, reduce morbidity, and enhance the quality of life has only begun to be investigated in recent years. To date, a sole randomized controlled clinical trial has been completed. This chapter summarizes what is currently known and what is unknown with respect to revascularization for the treatment of HFrEF.

scholarly journals Japanese sake yeast supplementation improves the quality of sleep: a double‐blind randomised controlled clinical trial

2015 ◽  
Vol 25 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Noriyuki Monoi ◽  
Ayumi Matsuno ◽  
Yuki Nagamori ◽  
Eriko Kimura ◽  
Yoshitaka Nakamura ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Quality Of Sleep ◽  
Double Blind ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

scholarly journals Phantom motor execution as a treatment for phantom limb pain: protocol of an international, double-blind, randomised controlled clinical trial

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021039 ◽  
Author(s):  
Eva Lendaro ◽  
Liselotte Hermansson ◽  
Helena Burger ◽  
Corry K Van der Sluis ◽  
Brian E McGuire ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Phantom Limb Pain ◽  
Phantom Limb ◽  
Controlled Clinical Trial ◽  
Motor Execution ◽  
Limb Pain ◽  
Double Blind ◽  
Randomised Controlled Clinical Trial ◽  
Randomised Controlled

IntroductionPhantom limb pain (PLP) is a chronic condition that can greatly diminish quality of life. Control over the phantom limb and exercise of such control have been hypothesised to reverse maladaptive brain changes correlated to PLP. Preliminary investigations have shown that decoding motor volition using myoelectric pattern recognition, while providing real-time feedback via virtual and augmented reality (VR-AR), facilitates phantom motor execution (PME) and reduces PLP. Here we present the study protocol for an international (seven countries), multicentre (nine clinics), double-blind, randomised controlled clinical trial to assess the effectiveness of PME in alleviating PLP.Methods and analysisSixty-seven subjects suffering from PLP in upper or lower limbs are randomly assigned to PME or phantom motor imagery (PMI) interventions. Subjects allocated to either treatment receive 15 interventions and are exposed to the same VR-AR environments using the same device. The only difference between interventions is whether phantom movements are actually performed (PME) or just imagined (PMI). Complete evaluations are conducted at baseline and at intervention completion, as well as 1, 3 and 6 months later using an intention-to-treat (ITT) approach. Changes in PLP measured using the Pain Rating Index between the first and last session are the primary measure of efficacy. Secondary outcomes include: frequency, duration, quality of pain, intrusion of pain in activities of daily living and sleep, disability associated to pain, pain self-efficacy, frequency of depressed mood, presence of catastrophising thinking, health-related quality of life and clinically significant change as patient’s own impression. Follow-up interviews are conducted up to 6 months after the treatment.Ethics and disseminationThe study is performed in agreement with the Declaration of Helsinki and under approval by the governing ethical committees of each participating clinic. The results will be published according to the Consolidated Standards of Reporting Trials guidelines in a peer-reviewed journal.Trial registration numberNCT03112928; Pre-results.

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