scholarly journals Prospective observational study of universal newborn eye screening in a hospital and community setting in New Zealand

2019 ◽  
Vol 3 (1) ◽  
pp. bmjpo-2018-000376 ◽  
Author(s):  
Samantha Kaye Simkin ◽  
Stuti L Misra ◽  
Malcolm Battin ◽  
Charles N J McGhee ◽  
Shuan Dai
Keyword(s):  
New Zealand ◽  
Optic Nerve ◽  
Congenital Cataract ◽  
Newborn Infants ◽  
Community Setting ◽  
Optic Nerve Hypoplasia ◽  
Wide Field ◽  
Ocular Abnormalities ◽  
Eye Screening ◽  
Retinal Haemorrhages

ObjectiveEarly detection of ocular abnormalities in newborn infants is essential for timely diagnosis and treatment. This study aimed to assess wide-field digital imaging for universal newborn eye screening (UNES) to determine the prevalence of ocular abnormalities, including retinal haemorrhages, in newborn infants in New Zealand.DesignProspective ocular screening study of infants.SettingA public hospital maternity ward and a community birth centre in Auckland, New Zealand.PatientsA total of 350 infants were enrolled in UNES, those with birth weight <1250 g or gestational age <30 weeks were excluded.MethodsWide-field digital images of the external eye and retina were captured by RetCam (Natus Medical, San Carlos, California, USA) and reviewed by an ophthalmologist via an established telemedicine methodology.Main outcome measuresDetection of ocular abnormalities, including retinal haemorrhages. Correlation between haemorrhages and maternal, obstetric and neonatal factors.ResultsA total of 346 infants completed screening (median age 2 days). Retinal haemorrhages were present in 50 cases (14.5%), two cases exhibited persistent retinal haemorrhages at 6-week follow-up. A significant increase in the odds of retinal haemorrhages was present for vaginal delivery compared with caesarean section. Other ocular abnormalities, including congenital cataract and optic nerve hypoplasia, were present in 1.4% of infants.ConclusionsOcular abnormalities were detected by UNES including congenital cataract and optic nerve hypoplasia. However, retinal haemorrhages, significantly associated with delivery modality, were the most common abnormality detected. The majority of retinal haemorrhages resolved spontaneously.

Neonatal eye screening for 203 healthy term newborns using a wide-field digital retinal imaging system

2019 ◽  
Author(s):  
Kenneth Teow Kheng Leong ◽  
Siti Nur Amira Abu Kassim ◽  
Jasvinjeet Kaur Sidhu ◽  
Zayani Zohari ◽  
Thivakar Sivalingam ◽  
...  
Keyword(s):  
Imaging System ◽  
Retinal Imaging ◽  
Common Finding ◽  
Wide Field ◽  
Retinal Haemorrhage ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Eye Screening ◽  
Term Newborns ◽  
Retinal Haemorrhages

Abstract Purpose This study aimed to determine the proportion and types of ocular abnormalities detected in healthy term newborns and also the risk factors associated with retinal haemorrhages. Method This cross-sectional study comprised of 203 participants, all healthy term newborn infants in the Obstetrics and Gynaecology ward at Hospital Kuala Lumpur over a six months period. The examination list includes external eye examination, red reflex test, and fundus imaging using a wide-field digital retinal imaging system (Phoenix Clinical ICON Paediatric Retinal Camera) by a trained Investigator. The pathologies detected were documented. The results were compared with similar studies previously published in the literature. Results Total ocular abnormalities were detected in 34% infants. The most common finding was retinal haemorrhage in 29.6% infants, of which 53.3% occurred bilaterally. Spontaneous vaginal delivery (SVD) remained the greatest risk factor which has nearly four times higher risk of newborns developing retinal haemorrhage compared to Lower Segment Caesarean Section (LSCS). There was a 6% increased likelihood of developing retinal haemorrhage for every 1 minute increment in the duration of 2nd stage of labour. Newborns delivered via SVD with episiotomy had 2.5 higher odds of developing retinal haemorrhage in newborns compared to SVD without episiotomy. Conclusion Universal eye screening for all newborns using a wide-field digital imaging system is possible, safe and useful in detecting posterior segment disorders. The most common abnormality detected is retinal haemorrhage. Although most resolve spontaneously, a longitudinal study is needed to study the long term effect of retinal haemorrhages in these infants.

Ocular findings in Universal Eye Screening of healthy, full-term newborn infant in Jakarta. The incidence and its risk factors: an observational study

2019 ◽  
Author(s):  
Rita S Sitorus ◽  
Indra Maharddhika Pambudy ◽  
Rinawati Rohsiswatmo ◽  
Julie Dewi Barliana ◽  
Dian Estu Yulia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Univariate Analysis ◽  
Newborn Infants ◽  
Retinal Hemorrhage ◽  
Full Term ◽  
Wide Field ◽  
Ocular Abnormalities ◽  
Term Newborn ◽  
Eye Screening ◽  
Ocular Abnormality

Abstract Background To document ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 hours after birth using the RetCam shuttle (Natus Medical Incorporated, USA). All eye findings were documented and analyzed according to obstetric and neonatal risk factors. Results Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common findings (88%) in which 2.67% involved the macula, followed with chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18-0.41, p<0.001) as the protective factor towards RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24-2.72, p=0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19-0.44, p<0.001), while other risk factors were not. Conclusions Our study supports previous reports that universal eye screening is an essential procedure which may detect several important ocular abnormalities. Retinal hemorrhage is the most common ocular abnormality and is associated with the methods of delivery and duration of labor. As the ocular abnormalities may go unnoticed during standard practice, a universal eye screening program could be considered as an essential part of newborn screening especially amongst those with prolonged labors.

scholarly journals Neonatal Eye Screening for 203 Healthy Term Newborns Using a Wide-Field Digital Retinal Imaging System

2020 ◽  
Author(s):  
Kenneth Teow Kheng Leong ◽  
Siti Nur Amira Abu Kassim ◽  
Jasvinjeet Kaur Sidhu ◽  
Zayani Zohari ◽  
Thivakar Sivalingam ◽  
...  
Keyword(s):  
Imaging System ◽  
Newborn Infants ◽  
Cross Sectional Study ◽  
Common Finding ◽  
Wide Field ◽  
Retinal Haemorrhage ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
Lower Segment Caesarean Section ◽  
Retinal Haemorrhages

Abstract Purpose: This study aimed to determine the proportion and types of ocular abnormalities detected in healthy term newborns and also the risk factors associated with retinal haemorrhages.Method: This cross-sectional study comprised of 203 participants, all healthy term newborn infants in the Obstetrics and Gynaecology ward at Hospital Kuala Lumpur over a six months period. The examination list includes external eye examination, red reflex test, and fundus imaging using a wide-field digital retinal imaging system (Phoenix Clinical ICON Paediatric Retinal Camera) by a trained Investigator. The pathologies detected were documented. The results were compared with similar studies previously published in the literature.Results: Total ocular abnormalities were detected in 34% infants. The most common finding was retinal haemorrhage in 29.6% infants, of which 53.3% occurred bilaterally. Spontaneous vaginal delivery (SVD) remained the greatest risk factor which has nearly 3.5 times higher risk of newborns developing retinal haemorrhage compared to Lower Segment Caesarean Section (LSCS). There was a 6% increased likelihood of developing retinal haemorrhage for every 1 minute increment in the duration of 2nd stage of labour. Conclusion: Universal eye screening for all newborns using a wide-field digital imaging system is possible, safe and useful in detecting posterior segment disorders. The most common abnormality detected is retinal haemorrhage. Although most resolve spontaneously, a longitudinal study is needed to study the long term effect of retinal haemorrhages in these infants.

scholarly journals Retinal abnormalities in universal eye screening of healthy, full-term newborn infants in Jakarta. The incidence and its risk factors: a pilot study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rita S. Sitorus ◽  
Indra Maharddhika Pambudy ◽  
Rinawati Rohsiswatmo ◽  
Julie Dewi Barliana ◽  
Dian Estu Yulia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Newborn Infants ◽  
Retinal Hemorrhage ◽  
Full Term ◽  
Common Finding ◽  
Wide Field ◽  
Ocular Abnormalities ◽  
Term Newborn ◽  
Eye Screening ◽  
Ocular Abnormality

Abstract Aim To screen for ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 h after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal findings were documented and analyzed according to obstetric and neonatal risk factors. Results Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common finding (88%) in which 2.67% involved the macula, followed by chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18–0.41, p < 0.001) was a protective factor against RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24–2.72, p = 0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19–0.44, p < 0.001), while other risk factors were not. Conclusions Our study showed that universal eye screening in healthy neonates is beneficial in the early diagnosis, monitoring and treatment of ocular abnormalities such as retinal hemorrhage, chorioretinitis and retinoblastoma. Retinal hemorrhage is the most common ocular abnormality and is associated with the delivery method and the duration of labor. Universal eye screening is visual-saving and life-saving for neonates with chorioretinitis, retinoblastoma as well as other abnormalities and should be mandatory in newborn screening.

Retinal abnormalities in Universal Eye Screening of healthy, full-term newborn infant in Jakarta. The incidence and its risk factors:  A Pilot study.

2019 ◽  
Author(s):  
Rita S Sitorus ◽  
Indra Maharddhika Pambudy ◽  
Rinawati Rohsiswatmo ◽  
Julie Dewi Barliana ◽  
Dian Estu Yulia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Univariate Analysis ◽  
Newborn Infants ◽  
Retinal Hemorrhage ◽  
Full Term ◽  
Wide Field ◽  
Ocular Abnormalities ◽  
Term Newborn ◽  
Eye Screening ◽  
Ocular Abnormality

Abstract Background: To document ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings. Methods: A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 hours after birth using the RetCam shuttle (Natus Medical Incorporated, USA). Retinal hemorrhages findings were documented and analyzed according to obstetric and neonatal risk factors. Results: Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common findings (88%) in which 2.67% involved the macula, followed with chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18-0.41, p<0.001) as the protective factor towards RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24-2.72, p=0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19-0.44, p<0.001), while other risk factors were not. Conclusions: Our study supports previous reports that universal eye screening is an essential procedure which may detect several important ocular abnormalities. Retinal hemorrhage is the most common ocular abnormality and is associated with the methods of delivery and duration of labor. As the ocular abnormalities may go unnoticed during standard practice, a universal eye screening program could be considered as an essential part of newborn screening especially amongst those with prolonged labors.

scholarly journals Neonatal eye screening for 203 healthy term new-borns using a wide-field digital retinal imaging system

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kenneth Teow Kheng Leong ◽  
Siti Nur Amira Abu Kassim ◽  
Jasvinjeet Kaur Sidhu ◽  
Zayani Zohari ◽  
Thivakar Sivalingam ◽  
...  
Keyword(s):  
Imaging System ◽  
Retinal Imaging ◽  
Common Finding ◽  
Wide Field ◽  
Retinal Haemorrhage ◽  
Cross Sectional ◽  
Ocular Abnormalities ◽  
New Born ◽  
Eye Screening ◽  
Eye Examination

Abstract Background The current practice for new-born eye examination by an Ophthalmologist in Malaysian hospitals is limited to only preterm new-borns, syndromic or ill infants. Healthy term new-borns are usually discharged without a thorough eye examination. This study is aimed at determining the proportion and types of ocular abnormalities detected in purportedly healthy term new-borns. Method This cross-sectional study is comprised of 203 participants, all purportedly healthy term new-born infants from the Obstetrics and Gynaecology ward at Hospital Kuala Lumpur over a 6 months period. The examination list includes external eye examination, red reflex test, and fundus imaging using a wide-field digital retinal imaging system (Phoenix Clinical ICON Paediatric Retinal Camera) by a trained Investigator. The pathologies detected were documented. The results were compared and correlated with similar studies published in the literature previously. Results Total ocular abnormalities were detected in 34% of the infants. The most common finding was retinal haemorrhage in 29.6% of the infants, of which 53.3% occurred bilaterally. Spontaneous vaginal delivery (SVD) remained the greatest risk factor which has nearly 3.5 times higher risk of new-borns developing retinal haemorrhage compared to Lower Segment Caesarean Section (LSCS). There was a 6% increased likelihood of developing retinal haemorrhage for every 1-min increment in the duration of 2nd stage of labour. Conclusion Universal eye screening for all new-borns using a wide-field digital imaging system is realistically possible, safe, and useful in detecting posterior segment disorders. The most common abnormality detected is retinal haemorrhage.

Clinical and demographic associations with optic nerve hypoplasia in New Zealand

2014 ◽  
Vol 98 (10) ◽  
pp. 1364-1367 ◽  
Author(s):  
Yi Wei Goh ◽  
Dale Andrew ◽  
Charles McGhee ◽  
Shuan Dai
Keyword(s):  
New Zealand ◽  
Optic Nerve ◽  
Optic Nerve Hypoplasia

Unilateral optic nerve hypoplasia in a case of septo-optic dysplasia

2021 ◽  
Author(s):  
R. El Hachimi ◽  
S. Benchekroun ◽  
R. El Hadiri ◽  
L.O. Cherkaoui
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Hypoplasia

scholarly journals Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil

Viruses ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 1
Author(s):  
Andréia Veras Gonçalves ◽  
Demócrito de B. Miranda-Filho ◽  
Líbia Cristina Rocha Vilela ◽  
Regina Coeli Ferreira Ramos ◽  
Thalia V. B. de Araújo ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Viral Infections ◽  
Case Series ◽  
Optic Nerve Hypoplasia ◽  
Endocrine Dysfunction ◽  
Careful Monitoring ◽  
Early Puberty ◽  
Growth Impairment ◽  
Appropriate Treatment ◽  
The Brain

Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary.

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