▾ Alfentanil in anaesthesia

Background Currently, the only approved muscle relaxant with a rapid onset and short duration of action is succinylcholine, a drug with some undesirable effects. Rapacuronium is an investigational nondepolarizing relaxant that also has a rapid onset and short duration and consequently should be compared with succinylcholine in its ability to facilitate rapid tracheal intubation. Methods This prospective, randomized clinical trial involved 336 patients. Anesthesia was induced with fentanyl and propofol and either 1.5 mg/kg rapacuronium or 1.0 mg/kg succinylcholine. The goal was to accomplish tracheal intubation by 60 s after administration of the neuromuscular blocking drug. Endotracheal intubation was performed, and conditions were graded by a blinded investigator. Recovery of neuromuscular function was assessed by electromyography. Results Intubation conditions were evaluated in 236 patients. Intubation by 60 s after drug administration occurred in 100% of patients with rapacuronium and in 98% with succinylcholine. Intubation conditions were excellent or good in 87% of patients with rapacuronium and in 95% with succinylcholine (P < 0.05). The time (median and range) to the first recovery of the train-of-four response was 8.0 (2.8-20.0) min with rapacuronium and 5.7 (1.8-17.7) min with succinylcholine (P < 0.05). The overall incidence of adverse effects was similar with both drugs. Conclusions A 1.5-mg/kg dose of rapacuronium effectively facilitates rapid tracheal intubation. It can be considered a valid alternative to 1.0 mg/kg succinylcholine for this purpose.

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Pharmacology of G-1-64, a new nondepolarizing neuromuscular blocking agent with rapid onset and short duration of action

Acta Anaesthesiologica Scandinavica ◽

10.1034/j.1399-6576.1999.430610.x ◽

1999 ◽

Vol 43 (6) ◽

pp. 651-657 ◽

Cited By ~ 18

Author(s):

L. Gyermek ◽

C. Lee ◽

N. Nguyen

Keyword(s):

Short Duration ◽

Blocking Agent ◽

Rapid Onset ◽

Neuromuscular Blocking ◽

Neuromuscular Blocking Agent ◽

Duration Of Action

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Effect of propofol on the haematological profile of pregnant Red Sokoto does

Savannah Veterinary Journal ◽

10.36759/svj.2018.002 ◽

2019 ◽

pp. 37-40

Keyword(s):

General Anaesthesia ◽

Jugular Vein ◽

Small Animal ◽

Rapid Onset ◽

Blood Parameters ◽

Duration Of Action ◽

Blood Samples ◽

Anaesthetic Agents ◽

Haematological Profile ◽

Apparently Healthy

Introduction: Propofol (Diprivan®) is now a mainstay drug during anaesthesia in human and small animal surgeries and this is as a result of its good quality anaesthesia, rapid onset, and short duration of action with rapid recoveries. There is paucity of information in Nigeria as per the use of general anaesthesia to carry out procedures in pregnant red Sokoto Does. The aim of this study is to assess the haematological profile of pregnant red Sokoto doe following propofol anaesthesia and also ascertain the safety of the drug during gestation. Methods: Ten apparently healthy pregnant Red Sokoto does were used for this study. The animals were acclimatised for two weeks and pregnancy was diagnosed using B-mode Real time® transcutaneous ultrasonography. The animals were grouped into two (A and B) comprising five animals each in their first and second trimesters respectively. Propofol at 4 mg/kg and 5 mg/kg was administered to the does in groups A and B respectively. Blood samples were collected via the jugular vein and analysed using full automated blood counter (Ehmma® PCE 210). Results: The result showed that the onset and duration of propofol anaesthesia at the two doses in both groups were smooth and rapid without much excitation. There were no significant (p < 0.05) differences in the blood parameters in both group when compared with the control. Significance: Our study lends credence to the fact that propofol anaesthesia is suitable and safe anaesthetic agents for induction and maintenance of general anaesthesia in pregnant red Sokoto does.

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Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2020.10.053 ◽

2021 ◽

Vol 534 ◽

pp. 988-994

Author(s):

Tomohisa Mori ◽

Yoshinori Takemura ◽

Takamichi Arima ◽

Yoshiyuki Iwase ◽

Michiko Narita ◽

...

Keyword(s):

G Protein ◽

Short Duration ◽

Rapid Onset

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Modern H1- antihistamines in the treatment of allergic rhinitis: focus on bilastine

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1462 ◽

2021 ◽

Vol 18 (2) ◽

pp. 66-76

Author(s):

Alexander V. Emelyanov ◽

Galina R. Sergeeva ◽

Evgenia V. Leshenkova

Keyword(s):

Allergic Rhinitis ◽

Experimental Studies ◽

Hepatic Metabolism ◽

Rapid Onset ◽

Perennial Allergic Rhinitis ◽

National Guidelines ◽

Duration Of Action ◽

Ocular Symptoms ◽

H1 Antihistamines ◽

Adults And Children

The second generation of H1-antihistamines is approved for the stepwise treatment of seasonal and perennial allergic rhinitis in adults and children by international and national guidelines. They reduce the severity of nasal and ocular symptoms of rhinitis and improve the quality of life of patients. Bilastine, a piperidine derivative, is a novel H1-antihistamine. It has a potent and selective effect on H1- receptors and a rapid onset and long duration of action and substantially reduces nasal and ocular symptoms of seasonal and perennial allergic rhinitis. Bilastine has no clinically substantial hepatic metabolism and has a high safety profile: it has no sedative effect, does not affect cognitive functions, has no cardiotoxic effects, and does not interact with alcohol and benzodiazepines in normal and high doses. Tachyphylaxis does not develop despite long-term (up to 1 year) use. Bilastine is registered for clinical use in adults and children aged 12 years. The results of clinical and experimental studies have demonstrated that bilastine has many of the features of modern H1-antihistamines recommended by international guidelines.

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Topical application of ASN008, a permanently charged sodium channel blocker, shows robust efficacy, a rapid onset and long duration of action in a mouse model of pruritus

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2019.06.518 ◽

2019 ◽

Vol 81 (4) ◽

pp. AB138

Keyword(s):

Mouse Model ◽

Sodium Channel ◽

Topical Application ◽

Channel Blocker ◽

Rapid Onset ◽

Sodium Channel Blocker ◽

Duration Of Action ◽

Long Duration

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Dose-Ranging Study in Younger Adult and Elderly Patients of ORG 9487, a New, Rapid-Onset, Short-Duration Muscle Relaxant

Anesthesia & Analgesia ◽

10.1213/00000539-199705000-00011 ◽

1997 ◽

Vol 84 (5) ◽

pp. 1011-1018 ◽

Cited By ~ 44

Author(s):

Raymond Kahwaji ◽

David R. Bevan ◽

George Bikhazi ◽

Colin A. Shanks ◽

Robert J. Fragen ◽

...

Keyword(s):

Elderly Patients ◽

Short Duration ◽

Muscle Relaxant ◽

Rapid Onset ◽

Org 9487 ◽

Dose Ranging

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Cluster Headache: Severity and Temporal Profiles of Attacks and Patient Activity Prior to And During Attacks

Cephalalgia ◽

10.1046/j.1468-2982.1981.0104209.x ◽

1981 ◽

Vol 1 (4) ◽

pp. 209-216 ◽

Cited By ~ 81

Author(s):

David Russell

Keyword(s):

Clinical Study ◽

Cluster Headache ◽

Short Duration ◽

Refractory Period ◽

Significant Positive Correlation ◽

Total Duration ◽

Rapid Onset ◽

Headache Severity ◽

Significant Difference ◽

Temporal Profiles

A detailed clinical study of 77 spontaneous cluster headache attacks has been carried out. The information was recorded during a period when patients were without medication and with the use of methods which were not dependent on the patients' memory of events. The findings stress the usual rapid onset and termination of attacks, and their short duration. There was a preponderance of attacks beginning during sleep and the majority of daytime attacks began when patients were physically relaxed. No significant difference between nocturnal and daytime attacks was found as regards severity or temporal profiles. A significant positive correlation was found between severity of maximal pain and both duration of maximal pain and total duration of attacks. “Abortive attacks” accounted for 16% of attacks. The apparent spontaneous arrest of these attacks does not appear to be due to special features of patient activity prior to or during attacks, nor are they restricted to a refractory period following more severe attacks.

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