▾ Enoximone and ▾ milrinone – inotropic vasodilators for severe heart failure

1991 ◽  
Vol 29 (10) ◽  
pp. 39-40
Keyword(s):  
Heart Failure ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Severe Heart Failure ◽  
Phosphodiesterase Inhibitors ◽  
First Line ◽  
Short Term ◽  
Failing Heart ◽  
Patients With Heart Failure

Enoximone (Perfan – Merrell) and milrinone (Primacor – Sterling-Winthrop) are phosphodiesterase inhibitors marketed for short-term intravenous use in patients with heart failure on intensive care units. The manufacturers claim that enoximone is ‘a first-line inotrope for the failing heart’ while milrinone is advocated for ‘resistant heart failure’. Are these drugs useful additions to existing treatments?

scholarly journals Changes in the Use of Intensive and Supportive Care with Heart Failure in the Last Month of Life Between 2001 and 2013

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 608-609
Author(s):  
Piling Chou ◽  
Peichao Lin
Keyword(s):  
Heart Failure ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Research Database ◽  
Global Epidemic ◽  
Research Guidelines ◽  
Patients With Heart Failure ◽  
End Stage ◽  
Analysis Of Claims Data ◽  
Over Time

Abstract Background Heart failure (HF) is a global epidemic affecting the elder globally. It is uncertain what care patients with heart failure receive at their end of life and what care trends are in the last month of life. OBJECTIVES: This study's objective was to investigate the changes in the use of intensive and supportive procedures for Taiwanese patients with heart failure in their last month of life during 2001-2013. Methods Analysis of claims data of 25,375 patients with heart failure obtained from the National Health Insurance Research Database was performed to investigate the changes in the use of intensive and supportive procedures for Taiwanese patients with heart failure in their last month of life during 2001-2013. Results Over the whole study period, 53.3% of patients with heart failure were admitted to intensive care units in their last month of life. The percentages of patients receiving mechanical ventilation (54.3%-41.5%), cardiopulmonary resuscitation (41.5%-16.7%), decreased over time. The percentages of patients receiving artificial hydration and nutrition (52.5.9%-56.8%) and extracorporeal membrane oxygenation(ECMO) (0.52%-1.78%) increased over time. Patients under 75 years old were more likely to be admitted to intensive care units. Conclusion Over time, supportive procedures increased, and intensive procedures decreased in patients with heart failure in the last month of life. This study highlights a need for research, guidelines, and training in how to provide palliative care for end-stage patients with heart failure.

scholarly journals The association between serum albumia and length of stay of intensive care units in patients with heart failure

2021 ◽  
Author(s):  
Tao Liu ◽  
Haochen Xuan ◽  
Lili Wang ◽  
Xiaoqun Li ◽  
Zhihao Lu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Intensive Care ◽  
Length Of Stay ◽  
Intensive Care Units ◽  
Medical Information ◽  
Smooth Curve ◽  
High Serum ◽  
Outcome Variable ◽  
Trend Test ◽  
Patients With Heart Failure

Abstract Objective: To assess the relationship between serum albumia and length of stay (LOS) of the intensive care units (ICUs).Design and Participants: we retrospectively analyze 2843 patients from the medical information mart for intensive care III (the MIMIC-III ) database. Materials and Methods: The exposure variable of the present study was serum albumia, which was defined as serum albumia level at the time of admission to ICUs. The outcome variable was LOS of ICUs. The final models were established by multivariate linear regression, and trend test and smooth fitting curves were used to evaluate the association between serum albumia level and LOS of ICUs. The subgroups were conducted based on age, sex and body mass index (BMI). Results: Higher serum albumia level can reduce LOS of ICUs in patients with heart failure (HF) than lower serum albumia level (β: -1.18; 95%CI: -1.50, -0.86; P <0.001). Trend test and smooth curve fittings suggested that LOS of ICUs was gradually shorten when serum albumia level was gradually increased. The subgroups based on age, sex and BMI demonstrated similar results between serum albumia level and LOS of ICUs.Conclusion: The negative correlation between serum albumia level and LOS of ICUs among patients with HF was found. High serum albumia level might reduce LOS of ICUs in patients with HF, and the conclusion might guide clinical treatments and judge prognosis.

scholarly journals Three dimensional echocardiography documents haemodynamic improvement by biventricular pacing in patients with severe heart failure

Heart ◽  
2001 ◽  
Vol 85 (5) ◽  
pp. 514-520
Author(s):  
W Y Kim ◽  
P Søgaard ◽  
P T Mortensen ◽  
H Kjærulf Jensen ◽  
A Kirstein Pedersen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Biventricular Pacing ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Walking Distance ◽  
Short Term ◽  
Bundle Branch Block ◽  
Patients With Heart Failure ◽  
Dimensional Echocardiography ◽  
Three Dimensional Echocardiography

OBJECTIVESTo quantify the short term haemodynamic effects of biventricular pacing in patients with heart failure and left bundle branch block by using three dimensional echocardiography.DESIGNThree dimensional echocardiography was performed in 15 consecutive heart failure patients (New York Heart Association functional class III or IV) with an implanted biventricular pacing system. Six minute walk tests were performed to investigate the effect of biventricular pacing on exercise capacity. Data were acquired at sinus rhythm and after short term (2–7 days) biventricular pacing.RESULTSCompared with baseline values, biventricular pacing significantly reduced left ventricular end diastolic volume (EDV) by mean (SD) 4.0 (5.1)% (p < 0.01) and end systolic volume (ESV) by 5.6 (6.4)% (p < 0.02). Mitral regurgitant fraction was significantly reduced by 11 (12.1)% (p < 0.003) and forward stroke volume (FSV) increased by 13.9 (18.6)% (p < 0.02). Exercise capacity was significantly improved with biventricular pacing by 48.4 (43.3)% (p < 0.00001). Regression analyses showed that the percentage increase in FSV independently predicted percentage improvement in walking distance (r2 = 0.73, p < 0.0002). Both basal QRS duration and QRS narrowing predicted pacing efficacy, showing a significant correlation with %ΔEDV, %ΔESV, and %ΔFSV.CONCLUSIONSIn five of 15 consecutive patients with heart failure and left bundle branch block, biventricular pacing induced a more than 15% increase in FSV, which predicted a more than 25% increase in walking distance and was accompanied by an immediate reduction in left ventricular chamber size and mitral regurgitation.

scholarly journals Psychological stress and short-term hospitalisations or death in patients with heart failure

Heart ◽  
2016 ◽  
Vol 102 (22) ◽  
pp. 1820-1825 ◽  
Author(s):  
Romano Endrighi ◽  
Andrew J Waters ◽  
Stephen S Gottlieb ◽  
Kristie M Harris ◽  
Andrew J Wawrzyniak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Psychological Stress ◽  
Short Term ◽  
Patients With Heart Failure

Anaemia and heart failure

Open Medicine ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. 11-25
Author(s):  
Enrico Vizzardi ◽  
Tania Bordonali ◽  
Elena Tanghetti ◽  
Marco Metra ◽  
Livio Cas
Keyword(s):  
Heart Failure ◽  
Ventricular Dysfunction ◽  
Severe Heart Failure ◽  
Left Ventricular ◽  
Favourable Effect ◽  
Heart Failure Trial ◽  
Patients With Heart Failure ◽  
Darbepoetin Alpha ◽  
Main Determinants ◽  
Independent Determinant

AbstractAnaemia is one of the most frequent co-morbidities in patients with heart failure. Its prevalence increases from 4% to7% in subjects with asymptomatic left ventricular dysfunction to >30% in patients with severe heart failure. Renal insufficiency, activation of inflammatory mediators and treatment with renin-angiotensin antagonists seem to be its main determinants. The results of many studies agree in providing evidence that anaemia is a powerful independent determinant of survival in patients with heart failure. However, the mechanisms of this relation are still not fully understood. Moreover a favourable effect of the correction of anaemia on prognosis has not yet been shown. Also In addition to this, controlled studies assessing its effects on exercise tolerance have yielded controversial results. Further research is needed to assess the effect of correcting anaemia in chronic heart failure (CHF) patients; ongoing reduction of events with RED-HF (Darbepoetin alpha in heart failure) trial will help define the role.

scholarly journals Bridge to ß Blockade in Severe Heart Failure: The Use of Phosphodiesterase Inhibitors

2000 ◽  
Vol 6 (3) ◽  
pp. 164-166 ◽  
Author(s):  
Khalid Muhammad ◽  
Hector O. Ventura ◽  
Dwight D. Stapleton ◽  
Frank W. Smart
Keyword(s):  
Heart Failure ◽  
Severe Heart Failure ◽  
Phosphodiesterase Inhibitors

Short-Term Effect of Cardiac Rehabilitation in Acute Stage in Patients with Heart Failure and Reduced Activities of Daily Living

2011 ◽  
Vol 17 (9) ◽  
pp. S167
Author(s):  
Ryuichiro Fukushima ◽  
Eiji Taguchi ◽  
Tomohiro Sakamoto ◽  
Kazuhiro Nishigami ◽  
Toshihiro Honda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Activities Of Daily Living ◽  
Cardiac Rehabilitation ◽  
Daily Living ◽  
Acute Stage ◽  
Term Effect ◽  
Short Term ◽  
Short Term Effect ◽  
Patients With Heart Failure
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