scholarly journals IDDF2018-ABS-0149 Manipulation of gut microbiota in in vitro model of colorectal cancer: positive effects of lactobacillus rhamnosus against fusobacterium nucleatum

2018 ◽  
Author(s):  
Tan Wei Jian ◽  
Norfilza Mohd Mokhtar ◽  
Raja Affendi Raja Ali ◽  
Wong Kon Ken
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
In Vitro Model ◽  
Lactobacillus Rhamnosus ◽  
Fusobacterium Nucleatum ◽  
Positive Effects ◽  
Vitro Model

scholarly journals Efficacy of DOPE/DC-cholesterol liposomes and GCPQ micelles as AZD6244 nanocarriers in a 3D colorectal cancer in vitro model

Nanomedicine ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. 331-344 ◽  
Author(s):  
Víctor López-Dávila ◽  
Tarig Magdeldin ◽  
Hazel Welch ◽  
Miriam Victoria Dwek ◽  
Ijeoma Uchegbu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
In Vitro Model ◽  
Vitro Model

scholarly journals The efficacy of cetuximab in a tissue-engineered three-dimensional in vitro model of colorectal cancer

2014 ◽  
Vol 5 ◽  
pp. 204173141454418 ◽  
Author(s):  
Tarig Magdeldin ◽  
Víctor López-Dávila ◽  
Cecile Villemant ◽  
Grant Cameron ◽  
Rosemary Drake ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
In Vitro Model ◽  
Three Dimensional ◽  
Vitro Model

In-vitro model for studying methanogens in human gut microbiota

Anaerobe ◽  
2015 ◽  
Vol 34 ◽  
pp. 50-52 ◽  
Author(s):  
William Tottey ◽  
Nadia Gaci ◽  
Guillaume Borrel ◽  
Monique Alric ◽  
Paul W. O'Toole ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
In Vitro Model ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Vitro Model

scholarly journals In vitro model insights into the role of human gut microbiota on arsenic bioaccessibility and its speciation in soils

2020 ◽  
Vol 263 ◽  
pp. 114580 ◽  
Author(s):  
Haifeng Chi ◽  
Yanwei Hou ◽  
Guofeng Li ◽  
Youchi Zhang ◽  
Frédéric Coulon ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
In Vitro Model ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Vitro Model

scholarly journals Effects of functional pasta ingredients on different gut microbiota as revealed by TIM-2 in vitro model of the proximal colon

2019 ◽  
Vol 10 (3) ◽  
pp. 301-313
Author(s):  
A. Martina ◽  
G.E. Felis ◽  
M. Corradi ◽  
C. Maffeis ◽  
S. Torriani ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
In Vitro Model ◽  
Bacillus Coagulans ◽  
Proximal Colon ◽  
Gene Profiling ◽  
Rrna Gene ◽  
Dietary Interventions ◽  
Vitro Model ◽  
Microbial Groups

Diet-related modulation of gut microbiota and its metabolic activity represents an intriguing research context, particularly in the case of disorders related to imbalances in gut microbial communities. We here explored the effects of Bacillus coagulans GBI-30, 6086 (BC30), β-glucans, and innovative whole-grain pastas, with or without these functional ingredients, on gut microbiota from three groups of children, presenting different susceptibility to type 1 diabetes, by using the well-controlled TNO in vitro model of the proximal colon (TIM-2). Short- and branched-chain fatty acids production and microbiota composition were assessed by means of gas chromatography and 16S rRNA gene profiling, respectively. In most cases, in vitro dietary interventions caused microbiota-dependent modulations as a result of intergroup variability, but also specific changes in microbial groups were shared between the three microbiotas, highlighting specific diet-microbial taxa connections.

A Novel In Vitro Model of Lymphatic Metastasis from Colorectal Cancer

2007 ◽  
Vol 143 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Peter S. Yoo ◽  
Abby L. Mulkeen ◽  
Alan Dardik ◽  
Charles H. Cha
Keyword(s):  
Colorectal Cancer ◽  
Lymphatic Metastasis ◽  
In Vitro Model ◽  
Vitro Model

scholarly journals A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3915
Author(s):  
Mônica Maurer Sost ◽  
Sanne Ahles ◽  
Jessica Verhoeven ◽  
Sanne Verbruggen ◽  
Yala Stevens ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
In Vitro Model ◽  
Citrus Fruit ◽  
Short Chain Fatty Acids ◽  
Overweight And Obesity ◽  
Fruit Extract ◽  
Healthy Human ◽  
Human Volunteers ◽  
Vitro Model

The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE led to a dose-dependent increase in Roseburia, Eubacterium ramulus, and Bacteroides eggerthii. There was a shift in production of short-chain fatty acids, where acetate production increased on CFE, while butyrate decreased. In overweight and obesity, acetate has been shown to increase fat oxidation when produced in the distal gut, and stimulate secretion of appetite-suppressive neuropeptides. Thus, the data in the in vitro model point towards mechanisms underlying the effects of the polyphenols in CFE with respect to modulation of the gut microbiota, both in composition and activity. These results should be confirmed in a clinical trial.

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