scholarly journals Primary biliary cholangitis and SARS-CoV-2 infection: incidence, susceptibility and outcomes

Gut ◽  
2021 ◽  
pp. gutjnl-2021-325700
Author(s):  
Javier Ampuero ◽  
Ana Lucena ◽  
Manuel Hernández-Guerra ◽  
Isabel Moreno-Moraleda ◽  
Juan Arenas ◽  
...  
2019 ◽  
Author(s):  
R Voitl ◽  
T Hippchen ◽  
C Zhang-Hagenlocher ◽  
KH Weiss ◽  
C Rupp

2018 ◽  
Vol 1 (2) ◽  
pp. 37-39
Author(s):  
Roongruedee Chaiteerakij

Autoimmuneliver diseases, particularly autoimmune hepatitis and primary biliary cholangitis,are not uncommon among the Thai population. This article summarizes main findings of studies of autoimmune liver diseases published during the past year, which included natural history and long-termoutcomes of primary biliary cholangitis treatment, a promising result of the new treatment for primary sclerosing cholangitis and outcomes of a second-line therapy of autoimmune hepatitis.


2020 ◽  
Author(s):  
Aidalina Mahmud ◽  
Poh Ying Lim ◽  
Hayati Kadir Shahar

BACKGROUND On March 18, 2020, the Malaysian government implemented Movement Control Order (MCO) to limit the contact rates among the population and infected individuals. OBJECTIVE The objective of this study was to forecast the trend of the COVID-19 epidemic in Malaysia in terms of its magnitude and duration. METHODS Data for this analysis was obtained from publicly available databases, from March 17 until March 27, 2020. By applying the Susceptible, Exposed, Infectious and Removed (SEIR) mathematical model and several predetermined assumptions, two analyses were carried out: without and with MCO implementation. RESULTS Without MCO, it is forecasted that it would take 18 days to reach the peak of infection incidence. The incidence rate would plateau at day 80 and end by day 94, with 43% of the exposed population infected. With the implementation of the MCO, it is forecasted that new cases of infection would peak at day 25, plateau at day 90 and end by day 100. At its peak, the infection could affect up to about 40% of the exposed population. CONCLUSIONS It is forecasted that the COVID-19 epidemic in Malaysia will subside soon after the mid-year of 2020. Although the implementation of MCO can flatten the epidemiological curve, it also prolongs the duration of the epidemic. The MCO can result in several unfavorable consequences in economic and psychosocial aspects. A future work of an exit plan for the MCO should also be devised and implemented gradually. The exit plan raises several timely issues of re-infection resurgence after MCO are lifted.


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