IDDF2021-ABS-0140 Gut microbiota significantly correlate with body constitution in traditional chinese medicine

AbstractCoronary heart disease (CHD) is a common ischaemic heart disease whose pathological mechanism has not been fully elucidated. Single target drugs, such as antiplatelet aggregation, coronary artery dilation and lipid-lowering medicines, can relieve some symptoms clinically but cannot effectively prevent and treat CHD. Accumulating evidence has revealed that alterations in GM composition, diversity, and richness are associated with the risk of CHD. The metabolites of the gut microbiota (GM), including trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) and bile acids (BAs), affect human physiology by activating numerous signalling pathways. Due to the advantage of multiple components and multiple targets, traditional Chinese medicine (TCM) can intervene in CHD by regulating the composition of the GM, reducing TMAO, increasing SCFAs and other CHD interventions. We have searched PubMed, Web of science, Google Scholar Science Direct, and China National Knowledge Infrastructure (CNKI), with the use of the keywords “gut microbiota, gut flora, traditional Chinese medicine, herbal medicine, coronary heart disease”. This review investigated the relationship between GM and CHD, as well as the intervention of TCM in CHD and GM, and aims to provide valuable insights for the treatments of CHD by TCM.

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Association between cancer-related fatigue and traditional Chinese medicine body constitution in female patients with breast cancer

Journal of Traditional and Complementary Medicine ◽

10.1016/j.jtcme.2020.08.005 ◽

2020 ◽

Author(s):

Sheuh-Mei Deng ◽

Aih-Fung Chiu ◽

Shin-Chung Wu ◽

Yu-Chuen Huang ◽

Shu-Chuan Huang ◽

...

Keyword(s):

Breast Cancer ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Female Patients ◽

Cancer Related Fatigue ◽

Body Constitution

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Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

Food & Function ◽

10.1039/c9fo00399a ◽

2019 ◽

Vol 10 (9) ◽

pp. 5886-5897 ◽

Cited By ~ 7

Author(s):

Wan Qu ◽

Shuo Liu ◽

Weijie Zhang ◽

Huawei Zhu ◽

Qian Tao ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Gut Microbiota ◽

Noncommunicable Diseases ◽

Mild Stress ◽

Chronic Unpredictable Mild Stress ◽

Brain Health ◽

Health Disorders ◽

Chinese Medicine Treatment ◽

Gut Microbiota Dysbiosis

Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.

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The effect of traditional Chinese medicine on gut microbiota in adults with type 2 diabetes

Medicine ◽

10.1097/md.0000000000022233 ◽

2020 ◽

Vol 99 (38) ◽

pp. e22233

Author(s):

Yujiao Zheng ◽

Qiyou Ding ◽

Lili Zhang ◽

Xiaowen Gou ◽

Yu Wei ◽

...

Keyword(s):

Type 2 Diabetes ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Gut Microbiota

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Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/8496817 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Wenfeng Xu ◽

Shuo Xu ◽

Shanshan Zhang ◽

Xuejun Wu ◽

Pengfei Jin

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Gut Microbiota ◽

Incubation Medium ◽

Toxic Elements ◽

The Other ◽

Traditional Chinese Medicines ◽

Chinese Medicines ◽

Scutellariae Radix

Niuhuang Jiedu tablet (NJT), a realgar (As2S2) containing Traditional Chinese Medicine (TCM), is a well-known formula. The safety of NJT is of growing concern since arsenic (As) is considered as one of the most toxic elements. NJT was demonstrated to be safer than realgar by our previous experiments and some other studies. The toxicity of realgar has been shown to be related to the amount of soluble or bioaccessible arsenic. In this study, the influences of the other TCMs in NJT on the bioaccessibility of arsenic from realgar, and the roles of gut microbiota during this process were investigated in vitro. Results showed that Dahuang (Rhei Radix et Rhizoma), Huangqin (Scutellariae Radix), Jiegeng (Platycodonis Radix), and Gancao (Glycyrrhizae Radix et Rhizoma) could significantly reduce the bioaccessibility of arsenic from realgar in artificial gastrointestinal fluids. Gut microbiota played an important role in decreasing the bioaccessibility of realgar because it was demonstrated to be able to absorb the soluble arsenic from realgar in the incubation medium. Dahuang, Huangqin, and Jiegeng could modulate the gut microbiota to enhance its arsenic absorption activity.

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Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2020.110857 ◽

2021 ◽

Vol 133 ◽

pp. 110857

Author(s):

Hai-Yu Zhang ◽

Jia-Xing Tian ◽

Feng-Mei Lian ◽

Min Li ◽

Wen-Ke Liu ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Gut Microbiota ◽

Metabolic Diseases ◽

Therapeutic Mechanisms

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Association study of diabetes mellitus and body constitution of traditional Chinese medicine

Traditional Medicine and Modern Medicine ◽

10.1142/s2575900019500022 ◽

2019 ◽

Vol 02 (01) ◽

pp. 1-6

Author(s):

Nabijan Mohammadturusn ◽

Yizhe Xu ◽

Fei Xu ◽

Yuanhao Zhang ◽

Zihui Tang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Total Sample ◽

Tolerance Test ◽

Oral Glucose ◽

Epidemiological Evidence ◽

Related Information ◽

Body Constitution ◽

Baseline Characteristics

Objective: We report on the association between traditional Chinese medicine (TCM) constitution and diabetes mellitus (DM) and provide epidemiological evidence for the theory of correlation between constitution and disease. Methods: A total of 3748 participants were used for data analysis, and all study subjects underwent a complete clinical baseline characteristics evaluation to collect related information. DM was determined by an oral glucose tolerance test. Multiple logistic regression (MLR) models were employed to detect the associations. Results: In total, 16.84% of the participants had DM in the total sample. Significant differences were found in age, height, weight, and heart rate, between the DM and non-DM groups. Univariate linear regression analyses indicated that the variables Qi_Deficient and Yang_Deficient were significantly associated with the outcome, and a negative correlation between TCM constitution and DM was found. After adjustment for relevant potential confounding factors, the MLR detected significant associations between both the Qi_Deficient and Yang_Deficient variables and DM ([Formula: see text]-value [Formula: see text] 0.015 for Qi_Deficient and [Formula: see text]-value [Formula: see text] for Yang_Deficient). In Qi_Deficient and Yin_Deficient participants, the odds ratios (ORs) for DM were 0.778 and 0.646, respectively. Conclusion: Qi_Deficient and Yang_Deficient were significantly associated with DM. These findings may provide insights for clinical practice for the prevention and diagnosis of DM.

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