Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

2019 ◽  
Vol 10 (9) ◽  
pp. 5886-5897 ◽  
Author(s):  
Wan Qu ◽  
Shuo Liu ◽  
Weijie Zhang ◽  
Huawei Zhu ◽  
Qian Tao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Noncommunicable Diseases ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Brain Health ◽  
Health Disorders ◽  
Chinese Medicine Treatment ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.

scholarly journals Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhi-Yi Yan ◽  
Hai-Yan Jiao ◽  
Jian-Bei Chen ◽  
Kai-Wen Zhang ◽  
Xi-Hong Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Target Genes ◽  
Network Pharmacology ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Active Ingredients ◽  
Chinese Medicine Formula ◽  
Treatment Of Depression

Background: Depression is a stress-related disorder that seriously threatens people’s physical and mental health. Xiaoyaosan is a classical traditional Chinese medicine formula, which has been used to treat mental depression since ancient times. More and more notice has been given to the relationship between the occurrence of necroptosis and the pathogenesis of mental disorders.Objective: The purpose of present study is to explore the potential mechanism of Xiaoyaosan for the treatment of depression using network pharmacology and experimental research, and identify the potential targets of necroptosis underlying the antidepressant mechanism of Xiaoyaosan.Methods: The mice model of depression was induced by chronic unpredictable mild stress (CUMS) for 6 weeks. Adult C57BL/6 mice were randomly divided into five groups, including control group, chronic unpredictable mild stress group, Xiaoyaosan treatment group, necrostatin-1 (Nec-1) group and solvent group. Drug intervention performed from 4th to 6th week of modeling. The mice in Xiaoyaosan treatment group received Xiaoyaosan by intragastric administration (0.254 g/kg/d), and mice in CUMS group received 0.5 ml physiological saline. Meanwhile, the mice in Nec-1 group were injected intraperitoneally (i.p.) with Nec-1 (10 mg/kg/d), and the equivalent volume of DMSO/PBS (8.3%) was injected into solvent group mice. The behavior tests such as sucrose preference test, forced swimming test and novelty-suppressed feeding test were measured to evaluate depressive-like behaviors of model mice. Then, the active ingredients in Xiaoyaosan and the related targets of depression and necroptosis were compiled through appropriate databases, while the “botanical drugs-active ingredients-target genes” network was constructed by network pharmacology analysis. The expressions of RIPK1, RIPK3, MLKL, p-MLKL were detected as critical target genes of necroptosis and the potential therapeutic target compounds of Xiaoyaosan. Furthermore, the levels of neuroinflammation and microglial activation of hippocampus were measured by detecting the expressions of IL-1β, Lipocalin-2 and IBA1, and the hematoxylin and eosin (H&E) stained was used to observe the morphology in hippocampus sections.Results: After 6-weeks of modeling, the behavioral data showed that mice in CUMS group and solvent group had obvious depressive-like behaviors, and the medication of Xiaoyaosan or Nec-1 could improve these behavioral changes. A total of 96 active ingredients in Xiaoyaosan which could regulate the 23 key target genes were selected from databases. Xiaoyaosan could alleviate the core target genes in necroptosis and improve the hippocampal function and neuroinflammation in depressed mice.Conclusion: The activation of necroptosis existed in the hippocampus of CUMS-induced mice, which was closely related to the pathogenesis of depression. The antidepressant mechanism of Xiaoyaosan included the regulation of multiple targets in necroptosis. It also suggested that necroptosis could be a new potential target for the treatment of depression.

scholarly journals A comparative study of the main constituents and antidepressant effects of raw and vinegar-baked Bupleuri Radix in rats subjected to chronic unpredictable mild stress

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32652-32663 ◽  
Author(s):  
Tianli Lei ◽  
Yadan Wang ◽  
Mingxiao Li ◽  
Xin Zhang ◽  
Chongning Lv ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Comparative Study ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Antidepressant Effects ◽  
Bupleurum Scorzonerifolium ◽  
Bupleuri Radix

Bupleuri Radix (BR) is a traditional Chinese medicine (TCM) widely used in Asian nations, which originates fromBupleurum chinenseDC orBupleurum scorzonerifoliumWilld.

Mechanisms of traditional Chinese medicine in modulating gut microbiota metabolites-mediated lipid metabolism

2021 ◽  
pp. 114207
Author(s):  
Yingying Li ◽  
Xinyu Ji ◽  
Haonan Wu ◽  
Xiang Li ◽  
Huamin Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota

scholarly journals Composition of “gold juice” using an ancient method based on intestinal microecology

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052093128
Author(s):  
Qiuwei Li ◽  
Liying Guo ◽  
Li Wang ◽  
Jing Miao ◽  
Huantian Cui ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Fecal Microbiota Transplantation ◽  
Antibiotic Use ◽  
Fecal Microbiota ◽  
Healthy Children ◽  
Fecal Samples ◽  
16S Rdna Sequence Analysis ◽  
History Of ◽  
Chinese Medicine Treatment

Objective To identify potentially effective bacterial components of gold juice, a traditional Chinese medicine treatment used for fecal microbiota transplantation. Methods Fecal samples were collected from five healthy children (two boys and three girls; mean age, 7.52 ± 2.31 years). The children had no history of antibiotic use or intestinal microecological preparation in the preceding 3 months. Fresh fecal samples were collected from children to prepare gold juice in mid-to-late November, in accordance with traditional Chinese medicine methods, then used within 7 days. Finally, 16S rDNA sequence analysis was used to identify potentially effective bacterial components of gold juice. QIIME software was used for comparisons of microbial species among gold juice, diluent, filtrate, and loess samples. Results Microflora of gold juice exhibited considerable changes following “ancient method” processing. Microbial components significantly differed between gold juice and filtrate samples. The gold juice analyzed in our study consisted of microbes that synthesize carbohydrates and amino acids by degrading substances, whereas the filtrate contained probiotic flora, Bacteroides, and Prevotella 9. Conclusions This study of microbial components in gold juice and filtrate provided evidence regarding effective bacterial components in gold juice, which may aid in clinical decisions concerning fecal microbiota transplantation.

scholarly journals Gut microbiota: a potential target for traditional Chinese medicine intervention in coronary heart disease

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Tian-Yi Cheng ◽  
Jia-Xin Li ◽  
Jing-Yi Chen ◽  
Pei-Ying Chen ◽  
Lin-Rui Ma ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Short Chain Fatty Acids ◽  
Lipid Lowering ◽  
China National Knowledge Infrastructure ◽  
Antiplatelet Aggregation ◽  
Single Target

AbstractCoronary heart disease (CHD) is a common ischaemic heart disease whose pathological mechanism has not been fully elucidated. Single target drugs, such as antiplatelet aggregation, coronary artery dilation and lipid-lowering medicines, can relieve some symptoms clinically but cannot effectively prevent and treat CHD. Accumulating evidence has revealed that alterations in GM composition, diversity, and richness are associated with the risk of CHD. The metabolites of the gut microbiota (GM), including trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs) and bile acids (BAs), affect human physiology by activating numerous signalling pathways. Due to the advantage of multiple components and multiple targets, traditional Chinese medicine (TCM) can intervene in CHD by regulating the composition of the GM, reducing TMAO, increasing SCFAs and other CHD interventions. We have searched PubMed, Web of science, Google Scholar Science Direct, and China National Knowledge Infrastructure (CNKI), with the use of the keywords “gut microbiota, gut flora, traditional Chinese medicine, herbal medicine, coronary heart disease”. This review investigated the relationship between GM and CHD, as well as the intervention of TCM in CHD and GM, and aims to provide valuable insights for the treatments of CHD by TCM.

scholarly journals Treatment of Oral Ulcer Based on TCM Syndrome Differentiation

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Ying Yao ◽  
Li Liu
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Severe Case ◽  
Oral Ulcer ◽  
Syndrome Differentiation ◽  
Tcm Syndrome ◽  
Chinese Medicine Treatment

Oral ulcer is a kind of ulcerative injury that occurs in the oral mucosa and is very common in clinic. In severe case, it can affect the quality of life of the patients. Western medicine treatment of oral ulcer is often prone to relapse, while the effect of traditional Chinese medicine treatment is remarkable.

scholarly journals On the Treatment of Kidney Fibrosis from the Theory of Internal Deficiency of Qi and the Coexistence of Phlegm and Blood Stasis

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Liu Min ◽  
Leng Wei
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Theoretical Basis ◽  
Renal Fibrosis ◽  
Blood Stasis ◽  
Point Of View ◽  
Kidney Fibrosis ◽  
Cause And Effect ◽  
Pathological Characteristics ◽  
Chinese Medicine Treatment

Traditional Chinese medicine believes that the etiology and pathogenesis of renal fibrosis are characterized by deficiency of the lung, spleen and kidney, and phlegm, blood stasis, dampness and poison. The positive and the evil can influence each other and cause and effect each other, forming the pathological characteristics of the deficiency, the deficiency, the deficiency and the reality. Chinese medicine treatment of the disease has its unique advantages, external and internal injury equal emphasis, correction and dispelling evil and regulation. From the point of view of "deficiency of qi and coexistence of phlegm and blood stasis", the treatment of renal fibrosis can provide theoretical basis for the treatment of the disease.

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