scholarly journals β-Blockers for secondary prevention in stable coronary artery disease: can observational studies provide valid answers?

Heart ◽  
2014 ◽  
Vol 100 (22) ◽  
pp. 1741-1742
Author(s):  
James S Floyd
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Secondary Prevention ◽  
Observational Studies ◽  
Stable Coronary Artery Disease ◽  
Β Blockers ◽  
Artery Disease

scholarly journals β-blockers, calcium antagonists, and mortality in stable coronary artery disease: an international cohort study

2019 ◽  
Vol 40 (18) ◽  
pp. 1399-1407 ◽  
Author(s):  
Emmanuel Sorbets ◽  
Philippe Gabriel Steg ◽  
Robin Young ◽  
Nicolas Danchin ◽  
Nicola Greenlaw ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cohort Study ◽  
Coronary Artery ◽  
Calcium Antagonists ◽  
Stable Coronary Artery Disease ◽  
Β Blockers ◽  
Artery Disease

Abstract 15942: Oral Anticoagulation as Compared to Oral Anticoagulation Plus Single Antiplatelet Therapy in Stable Coronary Artery Disease With Af: A Meta-analysis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Igor Vaz ◽  
Ashish Kumar ◽  
Mariam Shariff ◽  
Rajkumar P Doshi ◽  
Rafael Duarte
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Oral Anticoagulation ◽  
Observational Studies ◽  
Stable Coronary Artery Disease ◽  
Treatment Strategies ◽  
Statistical Heterogeneity ◽  
All Cause Mortality ◽  
Artery Disease ◽  
Stable Cad

Introduction: There are limited data on the appropriate antithrombotic therapy in patients with stable coronary artery disease (CAD) and concurrent atrial fibrillation (AF). The efficacy of using a single antiplatelet (SAP) in addition to oral anticoagulation (OAC) as compared to OAC alone remains controversial, with the earlier regimen associated with increased risk of major bleeding. Methods: A systematic electronic search of the PubMed, EMBASE and Cochrane databases was performed to identify relevant publications. Inclusion criteria were randomized controlled studies (RCTs) and observational studies comparing OAC+SAPT to OAC alone in patients with stable CAD and concurrent AF. All-cause mortality, stroke and myocardial infarction (MI) were the endpoints analyzed. We used the inverse variance method with random-effect model to calculate the hazard ratio (HR) with 95% confidence interval (CI). Statistical heterogeneity was calculated using Higgins I2 statistics. All statistical analysis was performed using RevMan Version 5.3. Results: The final analysis included two RCTs and 3 observational studies comparing OAC+SAPT versus OAC alone in patients with stable CAD and AF. There was no difference in the rate of mortality between the two treatment strategies [HR: 1.13, 95%CI: 0.88-1.46, I2= 71%] [Figure, PANEL A]. Subgroup analysis based on RCTs and observation studies reported similar results. Additionally, there was no difference in the rate of stroke [HR: 1.24, 95%CI: 0.83-1.85, I2= 0%] [Figure, PANEL B]or MI [HR: 0.57, 95%CI: 0.29-1.14, I2= 0%] [Figure, PANEL C] between the two treatment strategies Conclusion: OAC+SAPT as compared to OAC alone in patients with stable CAD and AF was associated with similar rates of all-cause mortality, stroke and MI.

scholarly journals Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia

2011 ◽  
Vol 65 (3-4) ◽  
pp. 94-101
Author(s):  
Inga Balode ◽  
Sanda Jēgere ◽  
Iveta Mintāle ◽  
Inga Narbute ◽  
Gustavs Latkovskis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Angiotensin Receptor Blockers ◽  
Stable Coronary Artery Disease ◽  
Pulse Palpation ◽  
Co Morbidity ◽  
Β Blockers ◽  
Artery Disease

Heart rate and other risk factors in outpatients with stable coronary artery disease in Latvia The aim of the study was to characterise coronary artery disease (CAD) outpatients in Latvia by risk factors (RF) including heart rate (HR), physical examination data, clinical data and treatment. Twelve practitioners had each examined and questioned 6 to 12 patients with established CAD (n = 120). The most frequent cardiovascular (CV) RF and co-morbidity were dyslipidemia (94.2%) and hypertension (78.3%), respectively. Prevalence of increased resting HR (≥70 bpm) was 35.9% and 33.6%, when measured by pulse palpation and electrocardiography, respectively. Regarding other RFs, prevalence of treated but insufficiently controlled blood pressure 140/90 mmHg, total cholesterol 1 > 5 mmol/l and triglycerides > 1.7 mmol/l was 25.8%, 30.1% and 33.3%, respectively. Aspirin, statins and angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers were used in 96.7%, 94.2% and 85.0% of cases, respectively. Beta blockers were used in 81.7% of cases. Average daily doses of most frequently used β blockers (metoprolol and bisoprolol) were 32% and 53% from target doses, respectively. In three cases β blockers were combined with ivabradin. Our results suggest that practitioners follow guidelines and consider CV prevention by treating CAD patients. Our data identified, however, unused potential for better control of increased HR by higher doses and combinations of HR-reducing agents.

Pattern of Use of β-Blockers in Older Patients with Stable Coronary Artery Disease

Drugs & Aging ◽  
2011 ◽  
Vol 28 (9) ◽  
pp. 703-711 ◽  
Author(s):  
Cristiana Vitale ◽  
Ilaria Spoletini ◽  
Maurizio Volterrani ◽  
Ferdinando Iellamo ◽  
Massimo Fini
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Older Patients ◽  
Stable Coronary Artery Disease ◽  
Β Blockers ◽  
Artery Disease

scholarly journals Dual Antiplatelet or Dual Antithrombotic Therapy for Secondary Prevention in High-Risk Patients with Stable Coronary Artery Disease?

2019 ◽  
Vol 119 (10) ◽  
pp. 1583-1589 ◽  
Author(s):  
Wael Sumaya ◽  
Tobias Geisler ◽  
Steen D. Kristensen ◽  
Robert F. Storey
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Secondary Prevention ◽  
Dual Antiplatelet Therapy ◽  
Stable Coronary Artery Disease ◽  
Risk Patients ◽  
History Of ◽  
Artery Disease

AbstractAntithrombotic treatment is a key component of secondary prevention following acute coronary syndromes (ACS). Although dual antiplatelet therapy is standard therapy post-ACS, duration of treatment is the subject of ongoing debate. Prolonged dual antiplatelet therapy in high-risk patients with history of myocardial infarction reduced the risk of recurrent myocardial infarction, stroke or cardiovascular death. Similarly, in patients with stable coronary artery disease, two-thirds of whom had a history of myocardial infarction, dual antithrombotic therapy with very-low-dose rivaroxaban and aspirin also resulted in improved ischaemic outcomes. In the absence of head-to-head comparison, choosing the most appropriate treatment strategy can be challenging, particularly when it comes to balancing the risks of ischaemia and bleeding. We aim to review the evidence for currently available antithrombotic treatments and provide a practical algorithm to aid the decision-making process.

scholarly journals INDICATIONS OF PRESCRIPTION OF STATINS IN TERTIARY CARE CENTRE OF NORTH INDIA

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Shilpa Atwal ◽  
Jitender Thakur
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Primary Prevention ◽  
Secondary Prevention ◽  
Stable Coronary Artery Disease ◽  
Tertiary Care ◽  
North India ◽  
Tertiary Care Centre ◽  
Unstable Coronary Artery Disease ◽  
Artery Disease

Background: To determine the indications for which statins are being prescribed Methods: Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months. Results: In our study, out of 243 prescriptions, 55.1%(n=134) were prescribed statins for secondary prevention and 44.9%(n=109) had statins prescribed for primary prevention. Overall coronary artery disease (37.03%) was the leading indication followed by Diabetes mellitus without ASCVD(70.64%).Other indications of secondary preventionincluded newly diagnosed statin naïve patients diagnosed with stable coronary artery disease ,unstable coronary artery disease /acute coronary artery disease , ischemic cardiovascular accidentsand peripheral arterial disease .64.22 percent patients in primary prevention group were diabetics in our study . Concluded: We concluded that secondary prevention was found to the more common indication of statin prescription than primary prevention (ratio 1.22:1). Keywords: Statin, CAD, Prevention

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