scholarly journals INDICATIONS OF PRESCRIPTION OF STATINS IN TERTIARY CARE CENTRE OF NORTH INDIA

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Shilpa Atwal ◽  
Jitender Thakur
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Primary Prevention ◽  
Secondary Prevention ◽  
Stable Coronary Artery Disease ◽  
Tertiary Care ◽  
North India ◽  
Tertiary Care Centre ◽  
Unstable Coronary Artery Disease ◽  
Artery Disease

Background: To determine the indications for which statins are being prescribed Methods: Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months. Results: In our study, out of 243 prescriptions, 55.1%(n=134) were prescribed statins for secondary prevention and 44.9%(n=109) had statins prescribed for primary prevention. Overall coronary artery disease (37.03%) was the leading indication followed by Diabetes mellitus without ASCVD(70.64%).Other indications of secondary preventionincluded newly diagnosed statin naïve patients diagnosed with stable coronary artery disease ,unstable coronary artery disease /acute coronary artery disease , ischemic cardiovascular accidentsand peripheral arterial disease .64.22 percent patients in primary prevention group were diabetics in our study . Concluded: We concluded that secondary prevention was found to the more common indication of statin prescription than primary prevention (ratio 1.22:1). Keywords: Statin, CAD, Prevention

scholarly journals Adherence to coronary artery disease secondary prevention medicines: exploring modifiable barriers

Open Heart ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. e000997 ◽  
Author(s):  
Rani Khatib ◽  
Kay Marshall ◽  
Jon Silcock ◽  
Claire Forrest ◽  
Alistair S Hall
Keyword(s):  
Coronary Artery Disease ◽  
Clinical Practice ◽  
Coronary Artery ◽  
Secondary Prevention ◽  
Tertiary Care ◽  
Self Report ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Modifiable Factors ◽  
Artery Disease

BackgroundNon-adherence to secondary prevention medicines (SPMs) among patients with coronary artery disease (CAD) remains a challenge in clinical practice. This study attempted to identify actual and potential modifiable barriers to adherence that can be addressed in cardiology clinical practice.MethodsThis was a cross-sectional, postal survey-based study of the medicines-taking experience of patients with CAD treated at a secondary/tertiary care centre. All participants had been on SPM for ≥3 months.ResultsIn total, 696 eligible patients were sent the survey and 503 responded (72.3%). The median age was 70 years, and 403 (80.1%) were male; the median number of individual daily doses of all medicines was 6. The rate of non-adherence to at least one SPM was 43.5% (n=219), but 53.3% of reported non-adherence was to only one SPM. Statins contributed to 66.7% and aspirin to 61.7% of overall non-adherence identified by the Single Question (SQ) tool. In 30.8% of non-adherent patients (n=65), this was at least partly intentional. Barriers included forgetfulness (84.9%; n=186), worry that medicines will do more harm than good (33.8%; n=74), feeling hassled about medicines taking (18.7%; n=41), feeling worse when taking medicines (14.2%; n=31) and not being convinced of the benefit of medicines (9.1%; n=20). In a multivariate analysis, modifiable factors associated with overall non-adherence included being prescribed aspirin (OR: 2.22; 95% CI: 1.18 to 4.17), having specific concern about SPM (OR: 1.12; 95% CI: 1.07 to 1.18) and issues with repeat prescriptions (OR: 2.48; 95% CI: 1.26 to 4.90). Different factors were often associated with intentional versus unintentional non-adherence.ConclusionsUsing appropriate self-report tools, patients share actual and potential modifiable barriers to adherence that can be addressed in clinical practice. Non-adherence behaviour was selective. Most non-adherence was driven by forgetfulness, concern about the harm caused by SPM and practical barriers.

TO STUDY THE USE OF GUIDELINES IN STATINS PRESCRIPTION AT TERTIARY CARE CENTRE OF NORTH INDIA

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Shilpa Atwal ◽  
Jitender Thakur
Keyword(s):  
Primary Prevention ◽  
Secondary Prevention ◽  
Tertiary Care ◽  
North India ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Total Study Population ◽  
Study Population

Background: To study the use of guidelines in statins prescription at tertiary care centre of North India Methods: Study was conducted on Patients with indications for statins presenting to cardiology OPD,Medicine OPD and Endocrinology OPD and started on statins at PGIMER, Chandigarh, within a period of 9 months. Results: In our study, 81.9% of total study population were receiving statins according to guideline and 18.1% were receiving statins not according to guideline. In the primary prevention group,91(83.5%) patients were receiving statins according to guideline and 18(16.5%) were receiving not according to guideline. In the secondary prevention group, 108(80.6%) patients were receiving statins according to guideline and 26(19.4%) patients were receiving statins not according to guideline. Concluded: In our study, more than two third of patients in our study were receiving prescriptions according to guideline Keywords: Statin, Guideline, Use

scholarly journals MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability

Open Heart ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. e001223 ◽  
Author(s):  
Sandeep Singh ◽  
Maurice W J de Ronde ◽  
Maayke G M Kok ◽  
Marcel AM Beijk ◽  
Robbert J De Winter ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Subclinical Atherosclerosis ◽  
Stable Coronary Artery Disease ◽  
Circulating Biomarkers ◽  
Unstable Coronary Artery Disease ◽  
Plaque Instability ◽  
Significant Difference ◽  
Differentially Expressed Mirnas ◽  
Artery Disease

BackgroundIn this study, we discovered and validated candidate microRNA (miRNA) biomarkers for coronary artery disease (CAD).MethodCandidate tissue-derived miRNAs from atherosclerotic plaque material in patients with stable coronary artery disease (SCAD) (n=14) and unstable coronary artery disease (UCAD) (n=25) were discovered by qPCR-based arrays. We validated differentially expressed miRNAs, along with seven promising CAD-associated miRNAs from the literature, in the serum of two large cohorts (n=395 and n=1000) of patients with SCAD and UCAD and subclinical atherosclerosis (SubA) and controls, respectively.ResultFrom plaque materials (discovery phase), miR-125b-5p and miR-193b-3p were most upregulated in SCAD, whereas miR-223-3p and miR-142-3p were most upregulated in patients with UCAD. Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR-223-3p, miR-133a-3p, miR-146-3p and miR-155-5p. The ischaemia-related miR-499-5p was also highly upregulated in patients with UCAD compared with the other groups (SCAD OR 20.63 (95% CI 11.16 to 38.15), SubA OR 96.10 (95% CI 40.13 to 230.14) and controls OR 15.73 (95% CI 7.80 to 31.72)). However, no significant difference in miR-499-5p expression was observed across SCAD, SubA and controls. MiR-122-5p was the only miRNA to be significantly upregulated in the serum of both patients with UCAD and SCAD.ConclusionIn conclusion, miR-122-5p and miR-223-3p might be markers of plaque instability.

scholarly journals Coronary artery disease in patients undergoing cardiac surgery for non-coronary lesions in a tertiary care centre

2014 ◽  
Vol 66 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Cholenahally Nanjappa Manjunath ◽  
Ashish Agarwal ◽  
Prabhavathi Bhat ◽  
Khandenahally Shankarappa Ravindranath ◽  
Rajiv Ananthakrishna ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cardiac Surgery ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Coronary Lesions ◽  
Artery Disease
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