Family history of myocardial infarction as an independent risk factor for coronary heart disease.

Abstract The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.

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Significance of plasma free fatty acid level for assessing and diagnosing acute myocardial infarction

Biomarkers in Medicine ◽

10.2217/bmm-2019-0291 ◽

2020 ◽

Vol 14 (9) ◽

pp. 739-747

Author(s):

Ying Kan ◽

Hairong Wang ◽

Jide Lu ◽

Zijun Lin ◽

Jie Lin ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

Fatty Acid ◽

Free Fatty Acid ◽

Independent Risk Factor ◽

Characteristic Curve ◽

Free Fatty Acid Level

Aim: To clarify the diagnostic value of the circulating free fatty acid (FFA) level for acute myocardial infarction (AMI) in coronary heart disease patients. Methods & results: A total of 1776 patients were screened by coronary angiography from October 2014 to February 2016. The plasma FFA level was significantly higher in coronary heart disease patients with lesions in three or more vessels than those with lesions in one or two vessels. Moreover, an elevated FFA level was identified as an independent risk factor for AMI on multivariate regression analysis and shown to be a sensitive and specific indicator for AMI diagnosis by receiver operating characteristic curve analysis. Conclusion: An elevated FFA level is an independent risk factor and independent diagnostic marker for AMI.

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Relation of the Leu40Arg variant of glycoprotein IIIA to personal and family history of myocardial infarction

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/v10046-009-0025-6 ◽

2009 ◽

Vol 63 (3) ◽

pp. 100-103

Author(s):

Normunds Līcis ◽

Gustavs Latkovskis ◽

Baiba Krivmane ◽

Milāna Zabunova ◽

Marina Berzina ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Significant Role ◽

Fibrinogen Receptor ◽

Glycoprotein Iiia ◽

History Of

Relation of the Leu40Arg variant of glycoprotein IIIA to personal and family history of myocardial infarction GPIIb/IIIa fibrinogen receptor is a key element of the thrombotic pathway. In this study, we investigated the possible relation of PlA1/A2 polymorphism (1565T>C; Leu33Pro) and a rare 1586T>G (Leu40Arg) variation of GPIIIa gene to personal and family history of myocardial infarction (MI) among 601 patients with angiographically confirmed coronary heart disease. Four hundred and fifteen patients had MI and 94 of individuals reported family history of premature MI. The Arg40 (1586G) variant (n = 4) was present exclusively in MI-patients and significantly correlated with a family history of premature MI (P = 0.013), whereas the Pro33 (1565C; PlA2) allele (n = 204) was similarly prevalent among different groups of patients. These data indicate the importance of the Arg40 variant but do not support a significant role of Pro33 allele in susceptibility to MI.

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Effects of coronary computer tomography angiography screening on smoking habits in asymptomatic individuals with family history of premature coronary heart disease

New Emirates Medical Journal ◽

10.2174/0250688201999200415094822 ◽

2020 ◽

Vol 01 ◽

Author(s):

Nadim Shah ◽

Mohamed Abdulla Alraqabani Almteiri ◽

Samer Noaman ◽

Nicholas Cox ◽

Chiew Wong ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Computer Tomography ◽

Smoking Habit ◽

Smoking Habits ◽

Premature Coronary Heart Disease ◽

History Of ◽

Computer Tomography Angiography

Background: The Screening for Asymptomatic Coronary Heart disease in the Siblings of young Myocardial Infarction patients study (SACHSMI) investigated the association between index myocardial infarction patient sibling(s) and obstructive coronary heart disease as detected by coronary computer tomography angiography (CCTA). The results of SACHSMI described a statistically significant association between smoking and prevalence of stenosis detected by CCTA. Data is lacking, however, regarding CCTA screening effects on smoking habits of young individuals. Methods: Fifty asymptomatic siblings of prospectively identified index myocardial infarction patients, aged 55 years or younger, were screened. These 50 sibling participants were shown and explained their CCTA results. The participants were followed using telephone call at 1 and 12 months after screening to assess any change in their smoking habits. The primary outcome of interest was to identify any change in smoking habit among the participants of the SACHSMI study undergoing CCTA 1 and 12 months post scanning. Results: Of the 50 participants, 20 (40%) had a history of smoking. One month post CCTA, 12 (60%; 95% confidence interval (CI): 36% to 81%) participants either stopped smoking (7/20 (35%; 95% CI: 15% to 59%)) or reduced (5/20 (25%; 95% CI: 9% to 49%)) the number of cigarettes smoked daily. At 12 months post CCTA, 11 (55%; 95% CI: 32% to 77%) participants either stopped smoking (6/20 (30%; 95% CI: 12% to 54%)) or reduced (5/20 (25%; 95% CI: 9% to 49%)) the number of cigarettes smoked daily. Conclusions: Screening individuals with family history of premature CHD via CCTA may have the additional benefit of reducing smoking in the short term.

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