EP430 Combination of FDG-PET metabolic parameters of cervical tumor and pelvic lymph nodes predict paraaortic lymph node involvement in locally advanced cervix cancer

2019 ◽  
Author(s):  
M Voglimacci ◽  
MA Angeles ◽  
A Lusque ◽  
H Leray ◽  
E Chantalat ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Fdg Pet ◽  
Locally Advanced ◽  
Lymph Node Involvement ◽  
Metabolic Parameters ◽  
Paraaortic Lymph Node ◽  
Cervical Tumor ◽  
Pelvic Lymph Nodes ◽  
Node Involvement

Anatomo-Pathological Problems in Radical Surgery of Prostatic Carcinoma: Lymph Nodes

1996 ◽  
Vol 63 (2) ◽  
pp. 188-191
Author(s):  
G. Severini ◽  
C. Morisi ◽  
M. Frigola ◽  
S. Arnone ◽  
S. Voce
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Prostatic Cancer ◽  
Prostatic Carcinoma ◽  
Advanced Disease ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Lymph Node Involvement ◽  
Retroperitoneal Lymphadenectomy ◽  
Node Involvement

One of biggest problems when assessing radical surgery of prostatic cancer is progression of the locally advanced disease when lymph nodes are positive. The following questions should be asked: 1) if there are patterns of lymph node involvement 2) if retroperitoneal lymphadenectomy is indispensable in pre-operative clinical removal 3) if the prognosis, in relation to lymph node invasion, worsens with the increase in number of positive lymph nodes or if the lesion becomes bilateral. The authors’ experience is reported.

18 Fluoro-2deoxy-d-Glucose-Positron Emission Tomography and Locally Advanced Cervical Cancer

2009 ◽  
Vol 19 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Stéphanie Motton ◽  
Thomas De Lapparent ◽  
Isabelle Brenot-Rossi ◽  
Max Buttarelli ◽  
Maryam Al Nakib ◽  
...  
Keyword(s):  
Lymph Node ◽  
Fdg Pet ◽  
Locally Advanced ◽  
False Negative ◽  
False Negative Rate ◽  
Lymph Node Involvement ◽  
Emission Tomography ◽  
Locally Advanced Cervical Cancer ◽  
Positron Emission ◽  
Node Involvement

Introduction:The aim of this study was to compare 18 fluoro-2deoxy-d-glucose-positron emission tomography (FDG-PET) after chemoradiation to histological findings after lymphadenectomy and radical hysterectomy and thus evaluate if FDG-PET could avoid surgery when negative.Methods:Twenty-one patients with locally advanced cervical cancer treated by chemoradiation, brachytherapy, and adjuvant surgery were prospectively enrolled. 18 Fluoro-2deoxy-d-glucose-PET was realized 5 weeks after concomitant chemoradiation and compared with histology.Results:18 Fluoro-2deoxy-d-glucose-PET assessed residual cervical involvement after chemoradiation with a sensitivity of 27.3%, specificity of 90%, and positive predictive value (PPV) of 75%. The negative predictive value (NPV) and the false-negative rate (FN) were 50%. Among patients with no evidence of disease on FDG-PET but with residual involvement on histology, 75% had residual involvement size under10 mm.For residual pelvic lymph node involvement, the specificity was 100%, NPV was 83.3%, and FN rate was 16.7%.For residual paraaortic lymph node involvement, specificity and sensitivity were 100%, but only 1 patient was concerned. Considering all the lymph node locations, sensitivity was 20%, specificity 100%, PPV 100%, and NPV 90%.Considering all localizations for each patient, control FDG-PET had a 30% sensitivity, 87% specificity, 80% PPV, and 43% NPV. False-negative rate was 43%.Conclusion:The aim of this study was to evaluate if control FDG-PET might avoid surgery for patients with a negative screening. Although FDG-PET is an interesting diagnostic test for residual lymph node involvement evaluation, it seems not accurate enough to be the only element of the surgery's indication. However, our sample size was too small to definitely conclude.

scholarly journals Influence of Covariates on Involved Lymph Nodes in Primary Breast Cancer Patients: Mixture Distribution Zero-Inflated Modeling Methodological Framework

2020 ◽  
Author(s):  
Madiha Liaqat ◽  
Shahid Kamal ◽  
Florian Fischer ◽  
Nadeem Zia
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Primary Breast Cancer ◽  
Negative Binomial ◽  
Lymph Node Involvement ◽  
Breast Cancer Patients ◽  
Node Involvement ◽  
Study Population

Abstract Background: Involvement of lymph nodes has been an integral part of breast cancer prognosis and survival. This study aimed to explore factors influencing on the number of auxiliary lymph nodes in women diagnosed with primary breast cancer by choosing an efficient model to assess excess of zeros and over-dispersion presented in the study population. Methods: The study is based on a retrospective analysis of hospital records among 5,196 female breast cancer patients in Pakistan. Zero-inflated Poisson and zero-inflated negative binomial modeling techniques are used to assess the association between under-study factors and the number of involved lymph nodes in breast cancer patients. Results: The most common breast cancer was invasive ductal carcinoma (54.5%). Patients median age was 48 years, from which women aged 46 years and above are the majority of the study population (64.8%). Examination of tumors revealed that over 2,662 (51.2%) women were ER-positive, 2,652 (51.0%) PR-positive, and 2,754 (53.0%) were Her2.neu-positive. The mean tumor size was 3.06 cm and histological grade 1 (n=2021, 38.9%) was most common in this sample. The model performance was best in the zero-inflated negative binomial model. Findings indicate that most factors related to breast cancer have a significant impact on the number of involved lymph nodes. Age is not contributed to lymph node status. Women having a larger tumor size suffered from greater number of involved lymph nodes. Tumor grades 11 and 111 contributed to higher numbers of positive lymph node.Conclusions: Zero-inflated models have successfully demonstrated the advantage of fitting count nodal data when both “at-harm” (lymph node involvement) and “not-at-harm” (no lymph node involvement) groups are important in predicting disease on set and disease progression. Our analysis showed that ZINB is the best model for predicting and describing the number of involved nodes in primary breast cancer, when overdispersion arises due to a large number of patients with no lymph node involvement. This is important for accurate prediction both for therapy and prognosis of breast cancer patients.

scholarly journals Correlation of lymph node size and their metastatic infiltration in gastric adenocarcinoma

2020 ◽  
Vol 7 (7) ◽  
pp. 2151
Author(s):  
Pratap Kumar Deb ◽  
Syed Abul Fazal
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Significant Proportion ◽  
Metastatic Potential ◽  
Lymph Node Involvement ◽  
Reliable Criterion ◽  
Lymph Node Size ◽  
Node Involvement ◽  
Carcinoma Stomach ◽  
High Chance

Background: In adenocarcinoma stomach, lymph node involvement is a significant predictor of survival, and a decisive factor in planning management. Size has always been an important criterion while considering the metastatic status of the node, in its radiological evaluation or otherwise. However, to what extent the size of a node can be considered as a reliable criterion for its metastatic potential remains a question.Methods: The present study is based on retrieving lymph nodes per operatively from patients of carcinoma stomach, measuring each node, evaluating its metastatic status and comparing the results to find a correlation between these two parameters.Results: The present study, examined a total of 187 nodes from 30 gastrectomy specimens. Among them, metastasis was found in 59 nodes (31.55%). Among these metastatic nodes, 34 (57.62%) were actually less than 5mm in size. Among the total sizes of all the lymph nodes examined, the mean±SD (standard deviation) of the metastasis positive nodes were found to be 6.42±3.86 mm, while that of the non-metastatic nodes were found to be 5.51±1.99 mm. However, it was also observed that larger nodes (>1 cm), tend to have a high chance of being malignant (62.5%).Conclusions: The above study shows though large nodes tend to be malignant, ignoring small nodes can lead to gross under staging or incomplete clearance while treating patients of adenocarcinoma stomach. Smaller nodes constitute a significant proportion of malignant nodes and must be evaluated. Size is not a reliable criterion of metastasis in lymph nodes of carcinoma stomach.

Renal Angiomyolipoma: Report of three cases with Regional Lymph Node Involvement and/or with Renal Cell Carcinoma

1995 ◽  
Vol 81 (6) ◽  
pp. 469-474 ◽  
Author(s):  
György Csanaky ◽  
Zoltán Szereday ◽  
Tamás Magyarlaki ◽  
Gábor Méhes ◽  
Tamás Herbert ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Malignant Transformation ◽  
Renal Cell ◽  
Dna Ploidy ◽  
Lymph Node Involvement ◽  
Node Involvement

Aims and background Angiomyolipomas (AMLs) are benign hamartoid tumors which frequently occur in tuberous sclerosis (TS). They may be manifest at different organ sites such as kidneys, lymph nodes, liver and lung and may be associated with renal cell carcinoma (RCC). The nature of multiple organ involvement in AML (metastasis versus multicentric synchronous tumors), the malignant transformation and the relation of AML to RCC have not been sufficiently clarified. Study design Three cases of renal AMLs in patients with tuberous sclerosis associated with lymphangioleiomyomatosis of the paraaortic lymph nodes and/or with RCC are reported. The concise clinical history of the patients as well as the findings of histology, immunohistochemistry and quantitative DNA analysis are presented. Results The multicentric form of AML and coincidence of renal AML and RCC were observed in 2 patients. AML and RCC were found within the same focus in one of the cases. RCCs were either aneuploid or “near diploid”, whereas one of the multicentric AMLs showed a discordant DNA ploidy pattern, namely aneuploidy in the kidney and diploidy in the lymph nodes. Conclusions The presented cases (all of them underwent periaortic lymphadenectomy) suggest that lymph node involvement in renal AML may be more frequent than expected (1-2% of all AMLs) on the basis of the few reported cases. The discordant DNA ploidy (renal versus lymph node lesions) observed in one of the cases with multicentric AML implies synchronous tumor growth at different sites rather than metastatic disease. The intimate coexistance of RCC and AML (RCC revealed by immunohistochemistry within a larger mass of renal AML) may indicate that malignant transformation of an AML should only be accepted, if such a coincidence is unequivocally excluded.

Lymphography in Sarcoidosis.

1974 ◽  
Vol 60 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Renato Musumeci ◽  
Carlo Uslenghi
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Pathological Findings ◽  
Node Biopsy ◽  
Node Involvement ◽  
Extensive Lymph Node

Abdominal lymphography was performed in 30 patients, 12 males and 18 females, with sarcoidosis. The diagnosis of disease was in every case histological, after mediastinal biopsy in 16 cases and after biopsy of lymph nodes in various sites in 14 cases. Mediastino-pulmonary involvement of varying degree was present in 23 patients. Lymphography revealed involvement of the inguinoretroperitoneal lymph nodes in 18 cases, bilateral in 15 of them. Lymphographic diagnosis of sarcoidosis is fairly arduous because the pattern elicited is very similar to that of lymphomas. The pathological findings were graded into 4 groups. No correlation between lymphographic pattern and duration and extent of the disease was demonstrated. In 5 patients with pathological lymphography lymph node biopsy confirmed the diagnosis. The routine use of lymphography in patients with sarcoidosis is not to be racommended because the demonstration of extensive lymph node involvement does not affect the treatment in any way.

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