scholarly journals Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component

2018 ◽  
Vol 71 (6) ◽  
pp. 483-492 ◽  
Author(s):  
Aoife J McCarthy ◽  
Runjan Chetty
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Cell Component ◽  
Spindle Cell Component ◽  
Cellular Atypia ◽  
Spindle Cells ◽  
Lipomatous Tumour ◽  
Morphological Diagnosis ◽  
Well Differentiated

This is a review of the morphological spectrum of fatty tumours containing a component of spindle cells, highlighting the immunohistochemical and cytogenetic workup that is now mandatory for accurate diagnosis, with the goal of providing a practical approach for practising surgical pathologists. There have been significant advances in recent years in classifying and understanding the pathogenesis of fatty tumours with spindle cells, based on the correlation of histological, immunohistochemical and cytogenetic/molecular findings. In spite of this, morphological diagnosis and accurate classification of fatty tumours with spindle cells can be challenging to diagnostic pathologists. A group of three lesions: spindle cell lipoma, mammary-type myofibroblastoma and cellular angiofibroma share morphological features and are united by retinoblastoma protein (pRb) loss. Closely allied to these lesions, especially spindle cell lipoma is the newly designated atypical spindle cell lipomatous tumour, which shares morphological, immunohistochemical and cytogenetic features with the trio of tumours lacking nuclear pRb. All of these lesions lack MDM2 and CDK4 amplification as well and separation is based on clinical features, principally location. Atypical lipomatous tumour or well-differentiated liposarcoma shows retention of pRb but overexpression and amplification of MDM2. Fatty tumours with spindle cells need to be extensively sampled, with careful attention paid to cellular atypia and location, and they need to have immunohistochemical workup with pRb, MDM2, desmin, CD34 and p16. In addition, cytogenetic analysis for MDM2 and CDK4 amplification has become crucial for the proper identification of these lesions.

scholarly journals Carcinosarcoma of lung

2013 ◽  
Vol 3 (5) ◽  
pp. 419-421
Author(s):  
S Neupane ◽  
T Pathak ◽  
S Bastola ◽  
S Shrestha ◽  
CB Pun
Keyword(s):  
Spindle Cell ◽  
Histopathological Examination ◽  
Small Cell ◽  
Brush Cytology ◽  
Cell Component ◽  
Squamous Cells ◽  
Spindle Cell Component ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Pulmonary Carcinosarcoma

Primary carcinosarcoma of the lung is exceedingly rare. It is described as malignancy composed of a mixture of carcinoma and sarcoma elements. The sarcomatous element is usually spindle cell but may contain cartilage, bone or skeletal muscle. We report a case of pulmonary carcinosarcoma in a 66 years male who presented with cough, chest pain on exertion, anorexia and weight loss. Brush cytology revealed poorly differentiated non-small cell carcinoma. Histopathological examination showed proliferation of malignant spindle cells containing bone and malignant cartilage admixed with areas of keratinized squamous cells with few foci of ill-defined glandular structure. On immunohistochemistry, carcinomatous component of tumor showed positivity for cytokeratin AE1/AE3 and spindle cell component were positive for vimentin. These findings led to diagnosis of carcinosarcoma. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 419-421 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7873

scholarly journals Biphasic Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: A Case Report

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 323
Author(s):  
Sang Hwa Lee ◽  
Hyunjin Kim ◽  
Min Ju Kim ◽  
Byungwha Kim ◽  
Hyun-Soo Kim
Keyword(s):  
Spindle Cell ◽  
Papillary Adenocarcinoma ◽  
Low Grade ◽  
Cell Component ◽  
Spindle Cell Component ◽  
Thyroid Transcription Factor 1 ◽  
Spindle Cells ◽  
Thyroid Transcription Factor ◽  
Nasopharyngeal Mass ◽  
Transcription Factor 1

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TLLG-NPPA) is a distinctly rare malignancy of the nasopharynx. Morphologically and immunophenotypically, TLLG-NPPA resembles papillary thyroid carcinoma (PTC) and is characterized by a papillary architecture with PTC-like nuclear features and thyroid transcription factor-1 expression. Recently, some cases of TLLG-NPPA with a spindle cell component have been reported. In this study, we report a very interesting case of biphasic TLLG-NPPA that was predominantly composed of spindle cells, with comprehensive analyses of its clinical, pathological, and immunophenotypical features. A 50-year-old woman presented with a sensation of a foreign body in the nasopharynx. Nasopharyngoscopy and computed tomography demonstrated a pedunculated mass arising from the nasopharyngeal roof. Based on the clinical impression of a nasopharyngeal tumor, an excisional biopsy was performed. At low-power magnification, the nasopharyngeal mass consisted of papillary tumor tissue, the growth pattern and architecture of which resembled those of PTC. The papillae were complex and packed tightly with fibrovascular cores. At high-power magnification, each papillary structure was lined with a pseudostratified cuboidal-to-columnar epithelium. The tumor cell nuclei frequently showed a ground-glass appearance, intranuclear grooves, pseudoinclusions, and membrane thickening and irregularity, resembling the characteristic nuclear morphology of PTC. These histological features were compatible with TLLG-NPPA. Intriguingly, in between the papillary components were spindle cells that appeared very similar to the glandular epithelial cells that imperceptibly merged with the papillary component. This spindle cell component comprised two-thirds of the entire tumor volume. The nuclear morphology of the spindle cell component was similar to that of the papillary component. On immunostaining, both the papillary and spindle cell components were diffusely and strongly positive for thyroid transcription factor-1, cytokeratin 7, cytokeratin 19, vimentin, and Hector Battifora mesothelial-1. In contrast, the tumor cells tested negative for p63, p40, smooth muscle actin, S-100, cytokeratin 5/6, thyroglobulin, BRAF V600E, and Epstein–Barr virus-encoded small RNAs. Only two cases of biphasic TLLG-NPPA exhibiting a prominent spindle cell component had been reported previously in the English literature. When the pathologist receives a primary nasopharyngeal mass with the aforementioned histological features, particularly biopsy specimens with predominant spindle cells, biphasic TLLG-NPPA should be considered in the differential diagnosis. By describing its detailed clinicopathological characteristics, we anticipate that this report will expand the existing knowledge on the spindle cell component associated with TLLG-NPPA.

scholarly journals Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (Lythognathus mormyrus)

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3413
Author(s):  
Massimo Orioles ◽  
Marco Galeotti ◽  
Pierpaolo Patarnello ◽  
Stefano Pizzolitto ◽  
Donatella Volpatti
Keyword(s):  
Spindle Cell ◽  
Giant Cells ◽  
Collagen Fibers ◽  
Sea Bream ◽  
Spindle Cell Lipoma ◽  
Marine Aquaculture ◽  
Spindle Cells ◽  
Adipocytic Tumors ◽  
Abundant Cytoplasm ◽  
The Masses

Cutaneous neoplasms affecting wild striped bream (Lythognathus mormyrus) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream.

scholarly journals Paratesticular Embryonal Rhabdomyosarcoma with Lung Metastasis – A Rare Case Report

2020 ◽  
Vol 7 (11) ◽  
pp. C164-168
Author(s):  
Anusha Ganapathi ◽  
Thanka J ◽  
Lawrence D'Cruze ◽  
Barathi G ◽  
Natarajan K ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Spermatic Cord ◽  
Rare Case ◽  
Spindle Cell ◽  
Malignant Tumors ◽  
Embryonal Rhabdomyosarcoma ◽  
Cell Component ◽  
Testicular Tumors ◽  
Spindle Cell Component ◽  
Rare Case Report

Paratesticular rhabdomyosarcomas (RMS) are very rare malignant tumors arising from the mesenchymal tissues of tunica, epididymis or spermatic cord. They present as painless hard masses in inguinoscrotal region, and large tumors can be mistaken for testicular tumors. They can spread to retroperitoneal lymph nodes or hematogenously metastasize to lung, bones and bone marrow. Here, we report a case of Embryonal RMS with spindle cell component presenting with painless scrotal mass and lung metastasis at initial diagnosis.

scholarly journals Canine Malignant Mammary Tumours II. Adenocarcinomas, Solid Carcinomas and Spindle Cell Carcinomas

1972 ◽  
Vol 9 (6) ◽  
pp. 447-470 ◽  
Author(s):  
W. Misdorp ◽  
E. Cotchin ◽  
J. F. Hampe ◽  
Anne G. Jabara ◽  
J. von Sandersleben
Keyword(s):  
Spindle Cell ◽  
Clinical Signs ◽  
Subjective Assessment ◽  
Simple Type ◽  
Well Differentiated ◽  
The Times ◽  
Lymphatic Permeation ◽  
Preliminary Classification ◽  
Mammary Adenocarcinomas

A preliminary classification of 130 canine mammary adenocarcinomas, 76 solid carcinomas, and nine spindle cell carcinomas, together with several subtypes, was constructed from pooled, selected (metastasized) material. Each tumour in this series was classified by subjective assessment of its quantitatively predominant histological picture. Many adenocarcinomas and solid carcinomas of simple type were infiltrative, and lymphatic permeation was often found. The complex types of adenocarcinomas and of solid carcinomas were expansive, and lymphatic permeation was rare. Some metastasized adenocarcinomas were well differentiated. The clinical signs, distribution of metastases and some preliminary data on the times of survival of dogs with various types of carcinomas are discussed.

Epithelioid Leiomyosarcoma of the External Deep Soft Tissue

2002 ◽  
Vol 126 (4) ◽  
pp. 468-470 ◽  
Author(s):  
Tetsuji Yamamoto ◽  
Rieko Minami ◽  
Chiho Ohbayashi ◽  
Mayumi Inaba
Keyword(s):  
Soft Tissue ◽  
Tumor Cells ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Immunohistochemical Analysis ◽  
Deep Soft Tissue ◽  
Cell Component ◽  
Spindle Cell Component

Abstract Epithelioid leiomyosarcoma in the external deep soft tissue is extremely rare. Most epithelioid leiomyosarcomas occur in the uterus. We present a case of epithelioid leiomyosarcoma occurring in the muscle of the thigh of a 78-year-old man. Histologically, the tumor predominantly consisted of round or polygonal cells arranged in sheets with a focal spindle cell component. Immunohistochemical analysis revealed that the tumor cells expressed vimentin, α-smooth muscle actin, and α-sarcomeric actin. The tumor was negative for desmin, S100 protein, glial fibrillary acidic protein, pan-keratin, epithelial membrane antigen, CAM 5.2, HMB-45, leukocyte common antigen, factor VIII–associated antigen, and CD34. Electron microscopically, some tumor cells contained abundant actin-type filaments in their cytoplasm.

Malignant Transformation of Metaplastic Thymoma into High-Grade Sarcomatoid Carcinoma: A Case Report

2021 ◽  
pp. 106689692110704
Author(s):  
Zheng Hua Piao ◽  
Jin Ping Chen ◽  
Hai Ren Chen ◽  
Xin Cheng Zhou
Keyword(s):  
Mediastinal Mass ◽  
Spindle Cell ◽  
Postoperative Radiotherapy ◽  
Sarcomatoid Carcinoma ◽  
Anterior Mediastinal Mass ◽  
High Grade ◽  
Ki 67 ◽  
Cellular Atypia ◽  
Spindle Cells ◽  
Cell Components

The correlation of histogenesis between metaplastic thymoma and thymic sarcomatoid carcinoma is unclear. We report a case of metaplastic thymoma transformed into high-grade sarcomatoid carcinoma. A 64  ×  54  ×  32 mm anterior mediastinal mass in a 61-year-old woman microscopically consisted mainly of classic metaplastic thymoma, with the center dominated by high-grade sarcomatoid carcinoma. In some areas, both epithelial and spindle cell components of the metaplastic thymoma showed increased cellular atypia, mitotic activity, and focal necrosis and gradually transformed into the polygonal/pleomorphic and spindle cell components of sarcomatoid carcinoma. Immunohistochemically, the characteristics of the polygonal/pleomorphic sarcomatoid cells were similar to those of the epithelial component of metaplastic thymoma, while the spindle sarcomatoid cells were more similar to the spindle cells component of metaplastic thymoma. The Ki-67 index was less than 5% in the metaplastic thymoma areas but up to 70% in the sarcomatoid carcinoma area. Radical operation and postoperative radiotherapy were performed. Multifocal relapses at the pleura occurred 13 months after surgery.

Pancreatic Carcinosarcoma with a Rare Presentation

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S65-S66
Author(s):  
J Khan ◽  
S Guo
Keyword(s):  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
World Health ◽  
Rare Entity ◽  
Cell Component ◽  
Rare Presentation ◽  
Term Survival ◽  
Cytoplasmic Staining ◽  
Spindle Cell Component ◽  
Head Of The Pancreas

Abstract Introduction/Objective Carcino-sarcoma of the pancreas is a rare tumor and very limited clinical and pathologic data have been reported in the literature. As per World Health Organization (WHO) classification of tumors of the digestive system, the carcinosarcoma of the pancreas is classified together with sarcomatoid carcinoma and anaplastic giant cell carcinomas in undifferentiated carcinoma of pancreas. Carcinosarcoma is a rare entity with very poor prognosis. Methods/Case Report Here we report a rare case of pancreatic carcinosarcoma in a 68 year old male patient who underwent a pancreatoduodenectomy for unilocular cystic mass in the head of the pancreas. The mass grossly replaces the whole head of the pancreas. Histologically, the lesion showed a high-grade spindle cell component and adjacent moderately differentiated adenocarcinoma. On immunohistochemical examination, the carcinomatous component was positive for epithelial markers, and the sarcomatous component was positive for DOG1 and had a focal cytoplasmic staining for S-100. The diagnosis of pancreatic carcinosarcoma was rendered. Treatment options are same as of pancreatic carcinoma. Surgical resection is the best option available for patients. Systemic chemotherapy is indicated for patients with distant metastasis or patients with other contraindications. Despite surgery and adjuvant chemotherapy, recurrence rates are high, and prognosis is poor. However, there are no relevant standard chemotherapies available. Based on the limited number of reported cases, the prognosis of carcinosarcoma of the pancreas appears to be poor. But some cases with long term survival have been reported. There are very few primary pancreatic neoplasms with carcinomatous and sarcomatous components reported in the current literature. Results (if a Case Study enter NA) NA Conclusion This case highlights the importance of familiarity with histopathology of this rare entity, and to order proper immunohistochemical and molecular work-up when there is a suspicious abnormal spindle cell component.

Sign in / Sign up

Export Citation Format

Share Document