scholarly journals Canine Malignant Mammary Tumours II. Adenocarcinomas, Solid Carcinomas and Spindle Cell Carcinomas

1972 ◽  
Vol 9 (6) ◽  
pp. 447-470 ◽  
Author(s):  
W. Misdorp ◽  
E. Cotchin ◽  
J. F. Hampe ◽  
Anne G. Jabara ◽  
J. von Sandersleben
Keyword(s):  
Spindle Cell ◽  
Clinical Signs ◽  
Subjective Assessment ◽  
Simple Type ◽  
Well Differentiated ◽  
The Times ◽  
Lymphatic Permeation ◽  
Preliminary Classification ◽  
Mammary Adenocarcinomas

A preliminary classification of 130 canine mammary adenocarcinomas, 76 solid carcinomas, and nine spindle cell carcinomas, together with several subtypes, was constructed from pooled, selected (metastasized) material. Each tumour in this series was classified by subjective assessment of its quantitatively predominant histological picture. Many adenocarcinomas and solid carcinomas of simple type were infiltrative, and lymphatic permeation was often found. The complex types of adenocarcinomas and of solid carcinomas were expansive, and lymphatic permeation was rare. Some metastasized adenocarcinomas were well differentiated. The clinical signs, distribution of metastases and some preliminary data on the times of survival of dogs with various types of carcinomas are discussed.

scholarly journals Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component

2018 ◽  
Vol 71 (6) ◽  
pp. 483-492 ◽  
Author(s):  
Aoife J McCarthy ◽  
Runjan Chetty
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Cell Component ◽  
Spindle Cell Component ◽  
Cellular Atypia ◽  
Spindle Cells ◽  
Lipomatous Tumour ◽  
Morphological Diagnosis ◽  
Well Differentiated

This is a review of the morphological spectrum of fatty tumours containing a component of spindle cells, highlighting the immunohistochemical and cytogenetic workup that is now mandatory for accurate diagnosis, with the goal of providing a practical approach for practising surgical pathologists. There have been significant advances in recent years in classifying and understanding the pathogenesis of fatty tumours with spindle cells, based on the correlation of histological, immunohistochemical and cytogenetic/molecular findings. In spite of this, morphological diagnosis and accurate classification of fatty tumours with spindle cells can be challenging to diagnostic pathologists. A group of three lesions: spindle cell lipoma, mammary-type myofibroblastoma and cellular angiofibroma share morphological features and are united by retinoblastoma protein (pRb) loss. Closely allied to these lesions, especially spindle cell lipoma is the newly designated atypical spindle cell lipomatous tumour, which shares morphological, immunohistochemical and cytogenetic features with the trio of tumours lacking nuclear pRb. All of these lesions lack MDM2 and CDK4 amplification as well and separation is based on clinical features, principally location. Atypical lipomatous tumour or well-differentiated liposarcoma shows retention of pRb but overexpression and amplification of MDM2. Fatty tumours with spindle cells need to be extensively sampled, with careful attention paid to cellular atypia and location, and they need to have immunohistochemical workup with pRb, MDM2, desmin, CD34 and p16. In addition, cytogenetic analysis for MDM2 and CDK4 amplification has become crucial for the proper identification of these lesions.

Ultrastructure of mesotheliomas

1984 ◽  
Vol 42 ◽  
pp. 98-101
Author(s):  
Irving Dardick
Keyword(s):  
Electron Microscopy ◽  
Latent Period ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
Metastatic Adenocarcinoma ◽  
Cell Sarcoma ◽  
Cytological Features ◽  
Industrial Use ◽  
Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

Threat of premature birth: psycho-social aspects

2016 ◽  
pp. 86-89
Author(s):  
S. Zhuk ◽  
◽  
O. Schurevska ◽  
Keyword(s):  
Pregnant Women ◽  
Physical Functioning ◽  
Premature Birth ◽  
Defense Mechanisms ◽  
Subjective Evaluation ◽  
Clinical Signs ◽  
Subjective Assessment ◽  
Psychological Status ◽  
Stress Load ◽  
Mandatory Participation

The objective: to study the psychological characteristics of women’s status in one of the most common complications of pregnancy - the threat of termination of pregnancy, depending on the level of stress load. Patients and methods. We have studied the psychological status (the Holmes-Rahe level of psychosocial stress, the Spielberg-Hanin level of anxiety, V.I.Dobryakov’s related to a pregnancy test, diagnosis of psychological defense mechanisms, assessment of quality of life) 60 pregnant women with threat of premature birth in the third trimester of pregnancy. Surveyed women were divided into 2 groups: group 1 included 30 pregnant women – forced migrant of Donetsk and Lugansk area and 2 group – 30 pregnant women who resided in Kiev. Results. At the same clinical picture of the threat of premature birth we detected discrepancy between the subjective assessment of their condition in women – forced migrants: a high level of situational and personal anxiety, decrease in physical (physical functioning, role-physical functioning) and psychological (social functioning, role emotional functioning) health, doubtful and pathological subtypes of gestational dominant. This creates prerequisites for complications of pregnancy, childbirth and postpartum future period and requires the participation of psychologists in the work with this category of patients. Conclusion. So, revealed a discrepancy between the objective clinical signs similar obstetric pathology (on the example of threatened abortion) in pregnant women with different levels of stress load and their subjective evaluation of their condition that affects their psychological status. This should be reflected in individually tailored therapy and be mainstreamed into the work of obstetricians and gynecologists with these patients, and requires mandatory participation of psychologists in the work with this category of patients. Key words: pregnancy, the threat of premature birth, stress, psychological status.

Objective and parametric methods used in functional classification disabled swimmers

Physiotherapy ◽  
2013 ◽  
Vol 21 (3) ◽  
Author(s):  
Natalia Uścinowicz ◽  
Wojciech Seidel ◽  
Paweł Zostawa ◽  
Sebastian Klich
Keyword(s):  
Medical Diagnosis ◽  
Olympic Games ◽  
Objective Evaluation ◽  
Subjective Assessment ◽  
Fair Play ◽  
Functional Classification ◽  
Kinematic Parameters ◽  
Athletes With Disabilities ◽  
Rule Out

AbstractThe recent Olympic Games in London incited much interest in the competition of disabled athletes. Various people connected with swimming, including coaches and athletes, have speculated about the fairness of competitions of disabled athletes. A constant problem are the subjective methods of classification in disabled sport. Originally, athletes with disabilities were classified according to medical diagnosis. Due to the injustice which still affects the competitors, functional classification was created shortly after. In the present review, the authors show the anomalies in the structure of the classification. The presented discovery led to the suggestion to introduce objective methods, thanks to which it would be no longer necessary to rely on the subjective assessment of the classifier. According to the authors, while using objective methods does not completely rule out the possibility of fraud by disabled athletes in the classification process, it would certainly reduce their incidence. Some of the objective methods useful for the classification of disabled athletes are: posturography, evaluation of the muscle parameters, electrogoniometric assessment, surface electromyography, and analysis of kinematic parameters. These methods have provide objective evaluation in the diagnostic sense but only if they are used in tandem. The authors demonstrate the undeniable benefits of using objective methods. Unfortunately, there are not only advantages of such solution, there also several drawbacks to be found. The conclusion of the article is the statement by the authors that it is right to use objective methods which allow to further the most important rule in sport: fair-play.

Malignant Ameloblastoma, Spindle Cell Variant

2003 ◽  
Vol 127 (3) ◽  
pp. 352-355
Author(s):  
Richard J. Zarbo ◽  
Mark T. Marunick ◽  
Robert Johns
Keyword(s):  
Spindle Cell ◽  
Intracranial Extension ◽  
Low Grade ◽  
Epithelial Proliferation ◽  
American Girl ◽  
Spindle Cell Proliferation ◽  
Histologic Pattern ◽  
Cell Variant ◽  
Well Differentiated ◽  
African American Girl

Abstract In this report, we document the histologic and clinical features of a previously undefined spindle cell variant of ameloblastoma that eventually behaved in a malignant fashion during a protracted course. The predominant histologic pattern was a well-differentiated, cellular, spindled epithelial proliferation arising in the maxilla of a 14-year-old African American girl. Over 19 years, the patient experienced numerous local recurrences, metastases to distant bones after 15 years, and finally bulky local recurrence with intracranial extension resulting in death. This ameloblastic malignancy histologically simulates a low-grade true sarcoma or an ameloblastic sarcoma, but differs in that the extensive spindle cell proliferation is epithelial, characterized by strong cytokeratin immunoreactivity and negative vimentin staining.

scholarly journals Revisiting the question of cutaneous vasculitis classification

2021 ◽  
Vol 97 (4) ◽  
pp. 48-59
Author(s):  
Alexey V. Samtsov ◽  
Vladislav R. Khairutdinov ◽  
Evgeny V. Sokolovskiy ◽  
Muza M. Kokhan ◽  
Irena E. Belousova ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Picture ◽  
Integrated Assessment ◽  
Clinical Signs ◽  
Cutaneous Vasculitis ◽  
Vascular Lesions ◽  
Instrumental Methods

Currently, there is no generally accepted terminology and classification of vasculitis and vascular cutaneous disorders. In Russia there are various approaches to the classification of cutaneous vasculitis vascular lesions are classified according to clinical signs, etiology and pathogenesis. Significant difficulties are caused by the lack of a unified terminology, clear diagnostic criteria for vasculitis and the existence of a large number of duplicate names, among which there are many eponymous terms. This issue is one of the most complex, confusing and debatable not only in dermatovenereology, but also in other disciplines. Modern principles of diagnosis of cutaneous vasculitis are based on an integrated assessment of the data of the disease history, clinical picture, laboratory and instrumental methods of examination. For standardization of definitions and diagnostic criteria, it is necessary, first of all, to adopt a unified interdisciplinary classification of vasculitis, which will be based on the etiopathogenetic principle. The applied unified classification of cutaneous vasculitis is proposed for discussion.

scholarly journals A review of the classification of nonstrabismic binocular vision anomalies

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Charles Darko-Takyi ◽  
Naimah Ebrahim Khan ◽  
Urvashni Nirghin
Keyword(s):  
Binocular Vision ◽  
Systemic Disease ◽  
Clinical Signs ◽  
Review Literature ◽  
Test Procedures ◽  
Convergence Insufficiency ◽  
Different Types ◽  
Proper Diagnosis ◽  
Divergence Insufficiency

There are conflicting and confusing ideas in literature on the different types of accommodative and vergence anomalies as different authors turn to classify them differently. This paper sought to review literature on the different classifications and types of nonstrabismic binocular vision anomalies and harmonize these classifications. Search engines, namely Google scholar, Medline, Cinahl and Francis databases, were used to review literature on the classification of accommodative and vergence dysfunctions using keywords like <em>binocular vision dysfunctions</em>, <em>classification of nonstrabismic binocular vision disorders or anomalies</em>, <em>accommodative disorders/anomalies classification</em> and <em>vergence disorders/anomalies classifications</em>, and included works that described these anomalies. Nonstrabismic binocular vision anomalies are classified as accommodative and vergence anomalies. There are three different major types of accommodative anomalies, namely accommodative insufficiency, accommodative infacility (accommodative inertia), and accommodative excess (accommodative spasm), and seven different types of vergence anomalies (convergence insufficiency, convergence excess, divergence insufficiency, divergence excess, basic esophoria, basic exophoria and fusional vergence dysfunctions), which are functional in origin. Functionally, there is a commonly reported interaction between accommodative and convergence insufficiency referred to as pseudoconvergence insufficiency. Accommodative paralysis (subtype of accommodative insufficiency) and vergence anomalies – <em>i.e.</em>, convergence paralysis, convergence spasm and divergence paralysis – are non-functional in origin with underlying systemic disease etiologies. Systemic convergence insufficiency, associated with subnormal accommodation, is a non-functional interaction between the accommodative and convergence insufficiency. The classification of nonstrabismic binocular vision anomalies is based on the description of the clinical signs and the underlying etiology either functional or non-functional in origin. Proper diagnosis and management involves investigation of the underlying etiology in addition to the battery of binocular vision test procedures.

Congenital and Pediatric Glaucomas, by Robert N. Shaffer, M.D., F.A.C.S. and Daniel I. Weiss, M.D. St. Louis: C. V. Mosby Company, 1970, 221 pp., $20.50

PEDIATRICS ◽  
1971 ◽  
Vol 47 (6) ◽  
pp. 1103-1104
Author(s):  
David S. Walton
Keyword(s):  
Final Section ◽  
Clinical Signs ◽  
Diagnostic Techniques ◽  
Operative Techniques ◽  
Concise Review ◽  
Detailed Classification ◽  
Methods Of Treatment

The authors begin their presentation–in this, the first textbook I know of devoted entirely to pediatric glaucomas–with a detailed classification of glaucomas in childhood. This is followed by a discussion of diagnostic techniques and the important clinical signs encountered in the pediatric glaucomas. A description of the conditions assoiated with childhood glaucomas follows, including a concise review of their distinguishing ocular features, with additional comments on treatment. The final section deals with methods of treatment; appropriate emphasis is given to the operative techniques used in performing a goniotomy.

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