scholarly journals O20.1 A Clinical Endocervical Neisseria gonorrhoeae Isolate Transiently Colonizes the Nonhuman Primate Lower Genital Tract

2021 ◽  
Author(s):  
O Soge ◽  
Y Cosgrove-sweeney ◽  
R Pascual ◽  
D Patton
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Nonhuman Primate ◽  
Genital Tract ◽  
Lower Genital Tract ◽  
Gonorrhoeae Isolate

Neisseria gonorrhoeae

2020 ◽  
pp. 1025-1032
Author(s):  
Jackie Sherrard ◽  
Magnus Unemo
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sexual Activity ◽  
Antimicrobial Therapy ◽  
Genital Tract ◽  
Systemic Disease ◽  
Gonococcal Infection ◽  
Gram Negative ◽  
Lower Genital Tract ◽  
Direct Inoculation ◽  
Sex With Men

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that is transmitted by direct inoculation of infected secretion from one mucosa to another. It primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. Oropharyngeal and rectal infections are common in men who have sex with men but also occur in women. N. gonorrhoeae is almost exclusively transmitted by sexual activity. Oropharyngeal and rectal infections usually produce no symptoms; disseminated gonococcal infection is a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; traditionally more common in women than men. The gonococcus has adapted rapidly to prevalent antimicrobial usage, leading to resistance to all antibiotics used for treatment, notably penicillins, fluoroquinolones, macrolides, tetracycline, and cephalosporins. This development has resulted in major concerns internationally and the introduction of international and national action/response plans as well as dual antimicrobial therapy.

Lower genital tract infection with Chlamydia trachomatis and Neisseria gonorrhoeae in Icelandic women with salpingitis

1986 ◽  
Vol 155 (3) ◽  
pp. 602-607 ◽  
Author(s):  
Sigurdur S. Magnússon ◽  
Thordur Oskarsson ◽  
Reynir T. Geirsson ◽  
Benedikt Sveinsson ◽  
Olafur Steingrimsson ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Neisseria Gonorrhoeae ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Lower Genital Tract ◽  
Lower Genital Tract Infection

Neisseria gonorrhoeae

2010 ◽  
pp. 722-727
Author(s):  
D. Barlow ◽  
Jackie Sherrard ◽  
C. Ison
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sexual Activity ◽  
Clinical Features ◽  
Genital Tract ◽  
Systemic Disease ◽  
Gonococcal Infection ◽  
Gram Negative ◽  
Urethral Discharge ◽  
Lower Genital Tract ◽  
Specific Symptoms

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. It is almost exclusively transmitted by sexual activity. Clinical features—(1) Oropharyngeal and rectal infections usually produce no symptoms; (2) men—dysuria (50%) and urethral discharge (98%) develop after a median of more than 5 days; complications, e.g. epididymitis, orchitis, are rare; (3) women—there are no specific symptoms in the absence of complications, e.g. salpingitis, bartholinitis; (4) disseminated gonococcal infection—a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; more common in women than men....

scholarly journals Cervicovaginal microbiota predicts Neisseria gonorrhoeae clinical presentation

2021 ◽  
Author(s):  
Angela Lovett ◽  
Arlene C. Seña ◽  
Andrew N. Macintyre ◽  
Gregory D. Sempowski ◽  
Joseph A. Duncan ◽  
...  
Keyword(s):  
Microbial Community ◽  
Neisseria Gonorrhoeae ◽  
Bacterial Vaginosis ◽  
Microbial Communities ◽  
Genital Tract ◽  
Trichomonas Vaginalis ◽  
Nucleic Acid Amplification ◽  
Genital Tract Infection ◽  
Lower Genital Tract ◽  
Asymptomatic Individuals

AbstractNeisseria gonorrhoeae infection of the female lower genital tract can present with a spectrum of phenotypes ranging from asymptomatic carriage to symptomatic cervical inflammation, or cervicitis. The factors that contribute to the development of asymptomatic or symptomatic infections are largely uncharacterized. We conducted a pilot study to assess differences in the cervicovaginal microbial community of patients presenting with symptomatic vs. asymptomatic N. gonorrhoeae infections to a sexually transmitted infections (STI) clinic. DNA was isolated from cervicovaginal swab specimens from women who tested positive for N. gonorrhoeae infection using a clinical diagnostic nucleic acid amplification test. We performed deep sequencing of 16S ribosomal RNA gene amplicons, followed by microbiome analyses with QIIME, and species-specific real-time PCR to assess the composition of microbial communities cohabitating the lower genital tract with the infecting N. gonorrhoeae. Specimens collected from asymptomatic individuals with N. gonorrhoeae infection and no co-infection with Chlamydia trachomatis and/or Trichomonas vaginalis carried Lactobacillus-dominant microbial communities more frequently than symptomatic patients without co-infection. When compared to asymptomatic individuals, symptomatic women had microbial communities characterized by more diverse and heterogenous bacterial taxa, typically associated with bacterial vaginosis (BV) (Prevotella, Sneathia, Mycoplasma hominis and Bacterial Vaginosis-Associated Bacterium-1 (BVAB1)/”Candidatus Lachnocurva vaginae). Both symptomatic and asymptomatic N. gonorrhoeae patients with additional STI co-infection displayed a BV-like microbial community. We used a murine model of N. gonorrhoeae infection in mice pre-colonized with Lactobacillus crispatus to test whether pre-existing L. crispatus was protective from N. gonorrhoeae colonization or whether N. gonorrhoeae infection could drive the loss of L. crispatus during infection. Vaginal infection with either N. gonorrhoeae strain 1291 or an isogenic mutant known to exhibit lower inflammatory had no impact on Lactobacillus burden recovered from the mice. These data taken together suggest that Lactobacillus-dominant vaginal microbial community may protect individuals from developing symptoms during lower genital tract infection with N. gonorrhoeae.

RESULTS OF LOWER GENITAL TRACT INFECTION INTERVENTION AMONG KHMER WOMEN OF CHILDBEARING AGE IN CAN THO IN 2016

2018 ◽  
pp. 83-89
Author(s):  
Trung Thuan Phan ◽  
Dinh Binh Tran ◽  
Thanh Hue Dinh ◽  
Phong Son Dinh ◽  
Kieu Oanh Truong ◽  
...  
Keyword(s):  
Genital Tract ◽  
Common Knowledge ◽  
Intervention Group ◽  
Effective Intervention ◽  
Control Group ◽  
Childbearing Age ◽  
Lower Genital Tract ◽  
Genital Tract Infections ◽  
Tract Infections ◽  
Can Tho City

Objectives: To find a model that is effective intervention to reduce the incidence of lower genital tract infections in Khmer women. Subjects and Methods: The intervention study is carried which compared the test group with the control group of 400 Khmer women, aged 15 to 49 in Can Tho city. Results: The common knowledge of the prevention of lower genital tract infections in the intervention group increased from 30.9% in the control group to 54.5% in the intervention group. The general attitude toward the use of lower genital tract infections increased from 22.3% in the control group to 78.0% in the intervention group. This is a very significant improvement. The prevalence of subclinical infection of the intervention group (26.0%) was significantly lower than that of the control group (39.3%), the difference was statistically significant. Conclusion: Intervention effectiveness is good in both knowledge, attitudes and practices, especially the effectiveness of interventions in practice in Khmer women. Key words: Effective intervention, lower genital tract infections, Khmer women, Can Tho city

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