Neisseria gonorrhoeae

2010 ◽  
pp. 722-727
Author(s):  
D. Barlow ◽  
Jackie Sherrard ◽  
C. Ison
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sexual Activity ◽  
Clinical Features ◽  
Genital Tract ◽  
Systemic Disease ◽  
Gonococcal Infection ◽  
Gram Negative ◽  
Urethral Discharge ◽  
Lower Genital Tract ◽  
Specific Symptoms

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. It is almost exclusively transmitted by sexual activity. Clinical features—(1) Oropharyngeal and rectal infections usually produce no symptoms; (2) men—dysuria (50%) and urethral discharge (98%) develop after a median of more than 5 days; complications, e.g. epididymitis, orchitis, are rare; (3) women—there are no specific symptoms in the absence of complications, e.g. salpingitis, bartholinitis; (4) disseminated gonococcal infection—a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; more common in women than men....

Neisseria gonorrhoeae

2020 ◽  
pp. 1025-1032
Author(s):  
Jackie Sherrard ◽  
Magnus Unemo
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sexual Activity ◽  
Antimicrobial Therapy ◽  
Genital Tract ◽  
Systemic Disease ◽  
Gonococcal Infection ◽  
Gram Negative ◽  
Lower Genital Tract ◽  
Direct Inoculation ◽  
Sex With Men

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that is transmitted by direct inoculation of infected secretion from one mucosa to another. It primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. Oropharyngeal and rectal infections are common in men who have sex with men but also occur in women. N. gonorrhoeae is almost exclusively transmitted by sexual activity. Oropharyngeal and rectal infections usually produce no symptoms; disseminated gonococcal infection is a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; traditionally more common in women than men. The gonococcus has adapted rapidly to prevalent antimicrobial usage, leading to resistance to all antibiotics used for treatment, notably penicillins, fluoroquinolones, macrolides, tetracycline, and cephalosporins. This development has resulted in major concerns internationally and the introduction of international and national action/response plans as well as dual antimicrobial therapy.

Lower genital tract infection with Chlamydia trachomatis and Neisseria gonorrhoeae in Icelandic women with salpingitis

1986 ◽  
Vol 155 (3) ◽  
pp. 602-607 ◽  
Author(s):  
Sigurdur S. Magnússon ◽  
Thordur Oskarsson ◽  
Reynir T. Geirsson ◽  
Benedikt Sveinsson ◽  
Olafur Steingrimsson ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Neisseria Gonorrhoeae ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Lower Genital Tract ◽  
Lower Genital Tract Infection

scholarly journals Relapsing Polychondritis: An Updated Review

Biomedicines ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 84 ◽  
Author(s):  
Francesco Borgia ◽  
Roberta Giuffrida ◽  
Fabrizio Guarneri ◽  
Serafinella Cannavò
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Functional Impairment ◽  
Clinical Presentation ◽  
Systemic Disease ◽  
Relapsing Polychondritis ◽  
Review Article ◽  
Therapeutic Options ◽  
Immune Mediated ◽  
Specific Symptoms

Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options.

scholarly journals Male urethritis with or without discharge: a clinico aetiological study in Hi-tech Medical College and Hospital Bhubaneswar, Odisha

2018 ◽  
Vol 4 (4) ◽  
pp. 484
Author(s):  
Binayak Chandra Dwari ◽  
Mamata Bhatt ◽  
Minati Mishra ◽  
Nalinikanta Tripathy ◽  
P. K. Sathpathy
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Economic Status ◽  
Causative Organism ◽  
Urine Specimen ◽  
Gonococcal Infection ◽  
Urethral Discharge ◽  
Medical College ◽  
Male Patients ◽  
Nongonococcal Urethritis ◽  
Acute Condition

<p class="abstract"><strong>Background:</strong> Urethritis or inflammation of the urethra is a multifactorial condition. Urethritis is called gonococcal urethritis (GU) when Neisseria gonorrhoeae is detected in urethral smear of the patient and nongonococcal urethritis (NGU) when this organism cannot be visualized.</p><p class="abstract"><strong>Methods:</strong> Urethritis cases were identified from the dermatology OPD record. A retrospective analysis of data of patients diagnosed as GU and NGU for a period of 5 years (from August 2012-July 2017) was made. We have included only male patients more than 10 year.<strong></strong></p><p class="abstract"><strong>Results:</strong> Neisseria gonorrhoeae (61.42%) and Chlamydia trachomatis (45.9%) were the most common causative organism among urethritis and nongonococcal urethritis (NGU) respectively. Chlamydia urethritis had been confirmed by demonstrating ≥5 polymorphonuclear lymphocytes (PMNLs) from the anterior urethra using a Gram stained urethral smear. Acute condition (7-14 days) more common in GU. Dysuria and purulent urethral discharge (68.6%) was more common in GU. In urine specimen pus cells count were more than 10. The most common age group was 21-30 year (42.86%). Most patients were from low socio-economic status (62.85%). Sexual exposure was more common in unmarried patients (94.74%). Heterosexual exposure (93.75%) was more common. Urethritis was also associated with other infection in 18 patients.</p><p class="abstract"><strong>Conclusions:</strong> Urethritis is inflammation of urethra which is manifested by dysuria with or without urethral discharge. Though there is increased incidence of Chlamydia infections, still now Gonococcal infection is the most common cause of urethritis.</p><p class="abstract"> </p>

scholarly journals Profil uretritis gonokokus dan uretritis non gonokokus di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari – Desember 2013

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Jonna Palenewen ◽  
Ferra O. Mawu ◽  
Nurdjanah J. Niode
Keyword(s):  
Sexual Orientation ◽  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Descriptive Study ◽  
Sexual Contact ◽  
Gram Negative Bacteria ◽  
Negative Bacterium ◽  
Gram Negative ◽  
Urethral Discharge ◽  
Gonococcal Urethritis

Abstract: Gonococcal urethritis (GU) is an inflammation of the urethra caused by Gram negative bacteria Neisseria gonorrhoeae associated with complaints of itching and burning sensation, pain during urination, mucopurulent urethral discharge from the tip of the urethra which sometimes bleeds, and pollakiuria. Non-gonococcal urethritis (NGU) is an inflammation of the urethra caused by Gram-negative bacterium Chlamydia trachomatis which is transmitted through sexual contact. Symptoms include mild dysuria, an uneasy feeling in the urethra, pollakiuria, and seropurulent urethral discharge. This study aimed to determine the profile of gonococcal urethritis and non-gonococcal urethritis in the Dermatovenereology Clinic of Prof. Dr. R. D. Kandou Hospital Manado from January-December 2013. This was a retrospective descriptive study based on the type of disease (GU or NGU), age, occupation, and sexual orientation. The results showed 204 cases of sexual transmitted infections (STIs). There were 27 cases of GU (6 %) and 10 cases of NGU (2 %). Most of GU and NGU patients were 25-44 years (17,46%) with private employment (17,47 %), and sexual orientation to heterosexual (37,10 %). Keywords: gonococcal urethritis, non-gonococcal urethritisAbstrak: Uretritis gonokokus (UG) ialah peradangan uretra disebabkan oleh bakteri Gram negatif Neisseria gonorrhoeae dengan keluhan gatal, panas, nyeri saat berkemih, dapat disertai keluar duh tubuh mukopurulen dari ujung uretra yang kadang mengeluarkan darah, dan polakisuria. Uretritis non gonokokus (UNG) ialah peradangan uretra disebabkan oleh bakteri Gram negatif Chlamydia trachomatis yang ditularkan melalui kontak seksual. Gejala berupa disuria ringan, perasaan tidak enak di uretra, polakisuria, dan keluarnya duh tubuh seropurulen. Penelitian ini bertujuan untuk mengetahui profil uretritis gonokokus dan non gonokokus di Poliklinik Kulit dan Kelamin RSUP Prof Dr. R. D. Kandou Manado periode Januari-Desember 2013. Jenis penelitian ini deskriptif retrospektif berdasarkan jenis penyakit (UG atau UNG), usia, pekerjaan, dan orientasi seksual. Hasil penelitian menunjukkan dari 204 kasus infeksi menular seksual (IMS) terdapat 27 kasus UG (6%) dan 10 kasus UNG (2%). Penderita terbanyak pada kelompok usia 25-44 tahun (17,46%), dengan pekerjaan swasta (17,47%), serta orientasi seksual dengan heteroseksual (37,100%).Kata kunci: uteritis gonokokus, uretritis non gonokokus

scholarly journals Cervicovaginal microbiota predicts Neisseria gonorrhoeae clinical presentation

2021 ◽  
Author(s):  
Angela Lovett ◽  
Arlene C. Seña ◽  
Andrew N. Macintyre ◽  
Gregory D. Sempowski ◽  
Joseph A. Duncan ◽  
...  
Keyword(s):  
Microbial Community ◽  
Neisseria Gonorrhoeae ◽  
Bacterial Vaginosis ◽  
Microbial Communities ◽  
Genital Tract ◽  
Trichomonas Vaginalis ◽  
Nucleic Acid Amplification ◽  
Genital Tract Infection ◽  
Lower Genital Tract ◽  
Asymptomatic Individuals

AbstractNeisseria gonorrhoeae infection of the female lower genital tract can present with a spectrum of phenotypes ranging from asymptomatic carriage to symptomatic cervical inflammation, or cervicitis. The factors that contribute to the development of asymptomatic or symptomatic infections are largely uncharacterized. We conducted a pilot study to assess differences in the cervicovaginal microbial community of patients presenting with symptomatic vs. asymptomatic N. gonorrhoeae infections to a sexually transmitted infections (STI) clinic. DNA was isolated from cervicovaginal swab specimens from women who tested positive for N. gonorrhoeae infection using a clinical diagnostic nucleic acid amplification test. We performed deep sequencing of 16S ribosomal RNA gene amplicons, followed by microbiome analyses with QIIME, and species-specific real-time PCR to assess the composition of microbial communities cohabitating the lower genital tract with the infecting N. gonorrhoeae. Specimens collected from asymptomatic individuals with N. gonorrhoeae infection and no co-infection with Chlamydia trachomatis and/or Trichomonas vaginalis carried Lactobacillus-dominant microbial communities more frequently than symptomatic patients without co-infection. When compared to asymptomatic individuals, symptomatic women had microbial communities characterized by more diverse and heterogenous bacterial taxa, typically associated with bacterial vaginosis (BV) (Prevotella, Sneathia, Mycoplasma hominis and Bacterial Vaginosis-Associated Bacterium-1 (BVAB1)/”Candidatus Lachnocurva vaginae). Both symptomatic and asymptomatic N. gonorrhoeae patients with additional STI co-infection displayed a BV-like microbial community. We used a murine model of N. gonorrhoeae infection in mice pre-colonized with Lactobacillus crispatus to test whether pre-existing L. crispatus was protective from N. gonorrhoeae colonization or whether N. gonorrhoeae infection could drive the loss of L. crispatus during infection. Vaginal infection with either N. gonorrhoeae strain 1291 or an isogenic mutant known to exhibit lower inflammatory had no impact on Lactobacillus burden recovered from the mice. These data taken together suggest that Lactobacillus-dominant vaginal microbial community may protect individuals from developing symptoms during lower genital tract infection with N. gonorrhoeae.

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