Application of real-time contrast-enhanced ultrasound in differential diagnosis of liver malignancies

2019 ◽  
Vol 97 (5) ◽  
pp. 341-344 ◽  
Author(s):  
Hongling Li ◽  
Jin Li
Keyword(s):  
Hepatocellular Carcinoma ◽  
Differential Diagnosis ◽  
Liver Cancer ◽  
Real Time ◽  
Contrast Enhanced Ultrasound ◽  
Portal Venous Phase ◽  
Contrast Enhanced ◽  
Different Types ◽  
Venous Phase ◽  
Malignant Liver

The objective of this study was to evaluate the value of real-time contrast-enhanced ultrasound in differential diagnosis of malignant liver tumors. Sixty patients pathologically diagnosed with liver cancer from May 2016 to May 2017 were selected as the subjects. All patients received ultrasonic diagnosis followed by the observation on dynamic contrast enhancement of the image and the analysis on perfusion characteristics and difference in contrast-enhanced ultrasound results in patients with different types of liver cancer. The signal during the arterial phase of 21 patients with well-differentiated hepatocellular carcinoma increased, including 12 cases of slow withdrawal of portal venous phase. The relative height of artery of 30 patients with middle-low differentiation of hepatocellular carcinoma increased along with the speed at which the contrast media was washed out at the end of the portal phase. In 9 patients with intrahepatic bile duct cancer, the enhancement of the arteries was slightly increased in the periphery of the tumor and low enhancement was found in the portal venous phase. There were some differences in the timing and the intensity of the enhancement of the ultrasound signals with 3 different types of diseases (P < 0.05). There are obvious differences in real-time contrast-enhanced ultrasound features of patients with different types of malignant liver tumor, which may provide references for clinical diagnosis.

Contrast-Enhanced Ultrasound in Hepatobiliary Interventions

2019 ◽  
Vol 03 (03) ◽  
pp. 240-242
Author(s):  
Johannes Rübenthaler ◽  
Vincent Schwarze ◽  
Constantin Marschner ◽  
Giovanna Negrão de Figueiredo ◽  
Dirk-André Clevert
Keyword(s):  
Real Time ◽  
Image Guidance ◽  
Treatment Success ◽  
Interventional Treatment ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Real Time Image ◽  
Magnetic Resonance Imaging Mri ◽  
Malignant Liver ◽  
Time Image

AbstractContrast-enhanced ultrasound (CEUS) has been widely accepted as a diagnostic tool for the detection and evaluation of benign and malignant liver lesions and has been implemented into the clinical routine as a tool for percutaneous interventional real-time image guidance. CEUS can be combined with computed tomography (CT) and magnetic resonance imaging (MRI) datasets using real-time image fusion to additionally surveil proper interventional treatment and assess treatment success. This review describes the state-of-the-art use of CEUS for the surveillance and monitoring of interventional procedures of the liver and for the evaluation of postinterventional success.

scholarly journals Preoperative Prediction of Microvascular Invasion in Patients With Hepatocellular Carcinoma Based on Radiomics Nomogram Using Contrast-Enhanced Ultrasound

2021 ◽  
Vol 11 ◽  
Author(s):  
Di Zhang ◽  
Qi Wei ◽  
Ge-Ge Wu ◽  
Xian-Ya Zhang ◽  
Wen-Wu Lu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Size ◽  
Multivariate Logistic Regression Analysis ◽  
Microvascular Invasion ◽  
Validation Dataset ◽  
Contrast Enhanced Ultrasound ◽  
Clinical Model ◽  
Portal Venous Phase ◽  
Preoperative Prediction ◽  
Contrast Enhanced

PurposeThis study aimed to develop a radiomics nomogram based on contrast-enhanced ultrasound (CEUS) for preoperatively assessing microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients.MethodsA retrospective dataset of 313 HCC patients who underwent CEUS between September 20, 2016 and March 20, 2020 was enrolled in our study. The study population was randomly grouped as a primary dataset of 192 patients and a validation dataset of 121 patients. Radiomics features were extracted from the B-mode (BM), artery phase (AP), portal venous phase (PVP), and delay phase (DP) images of preoperatively acquired CEUS of each patient. After feature selection, the BM, AP, PVP, and DP radiomics scores (Rad-score) were constructed from the primary dataset. The four radiomics scores and clinical factors were used for multivariate logistic regression analysis, and a radiomics nomogram was then developed. We also built a preoperative clinical prediction model for comparison. The performance of the radiomics nomogram was evaluated via calibration, discrimination, and clinical usefulness.ResultsMultivariate analysis indicated that the PVP and DP Rad-score, tumor size, and AFP (alpha-fetoprotein) level were independent risk predictors associated with MVI. The radiomics nomogram incorporating these four predictors revealed a superior discrimination to the clinical model (based on tumor size and AFP level) in the primary dataset (AUC: 0.849 vs. 0.690; p &lt; 0.001) and validation dataset (AUC: 0.788 vs. 0.661; p = 0.008), with a good calibration. Decision curve analysis also confirmed that the radiomics nomogram was clinically useful. Furthermore, the significant improvement of net reclassification index (NRI) and integrated discriminatory improvement (IDI) implied that the PVP and DP radiomics signatures may be very useful biomarkers for MVI prediction in HCC.ConclusionThe CEUS-based radiomics nomogram showed a favorable predictive value for the preoperative identification of MVI in HCC patients and could guide a more appropriate surgical planning.

Diagnostic accuracy of contrast-enhanced ultrasound for the differential diagnosis of hepatocellular carcinoma

2017 ◽  
Vol 29 (9) ◽  
pp. 1036-1044 ◽  
Author(s):  
Barbara Schellhaas ◽  
Ruediger S. Görtz ◽  
Lukas Pfeifer ◽  
Christian Kielisch ◽  
Markus F. Neurath ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Differential Diagnosis ◽  
Diagnostic Accuracy ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced

scholarly journals Intraoperative Cerebral Glioma Characterization with Contrast Enhanced Ultrasound

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Francesco Prada ◽  
Luca Mattei ◽  
Massimiliano Del Bene ◽  
Luca Aiani ◽  
Marco Saini ◽  
...  
Keyword(s):  
Real Time ◽  
Flow Distribution ◽  
Distribution Patterns ◽  
Cerebral Glioma ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Venous Phase ◽  
First Time ◽  
Fast Perfusion

Background. Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before.Aim. To perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas.Methods. We performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology.Results. We observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns.Conclusion. Our study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors’ biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.

scholarly journals Contrast-enhanced Ultrasound Features of Intrahepatic Cholangiocarcinoma: A New Perspective

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tianjiao Chen ◽  
Xiaoyan Chang ◽  
Ke Lv ◽  
Yong Wang ◽  
Xianshui Fu ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Color Doppler ◽  
Arterial Phase ◽  
Contrast Enhanced Ultrasound ◽  
Color Doppler Flow Imaging ◽  
Portal Venous Phase ◽  
Contrast Enhanced ◽  
Color Doppler Flow ◽  
Venous Phase ◽  
New Perspective

AbstractThe objective of this study was to illustrate our specific findings for intrahepatic cholangiocarcinoma (ICC) lesions on contrast-enhanced ultrasound (CEUS). In this study, 21 patients at our hospitals with pathologically proven ICC and CEUS data were retrospectively enrolled. General clinical data of the patients, and features of lesions on conventional and contrast-enhanced ultrasound were recorded. Two experienced radiologists retrospectively reviewed all images by consensus. On gray-scale sonography, hypoechoic, isoechoic and hyperechoic lesions accounted for 85.7%, 9.5% and 4.8%, respectively, of all lesions. Hypovascular patterns were found for 95.2% of the lesions on color Doppler flow imaging. During the arterial phase of CEUS, heterogeneous hyperenhancement, homogeneous hyperenhancement, rim-like hyperenhancement, isoenhancement and hypoenhancement were observed for 61.9%, 19.0%, 9.5%, 4.8%, 4.8% of the lesions, respectively. During the portal venous and late phases, 85.7% and 95.2% of the lesions, respectively, exhibited hypoenhancement. In addition, 66.7% of the ICC lesions exhibited washed-out interiors but little decrease in enhancement at the periphery during the portal venous phase, resulting in the formation of a hyperenhanced peripheral rim. In conclusion, the rim sign in the portal venous phase of CEUS could help diagnose ICC. This trait could be related to the infiltrating growth pattern of ICC.

Sign in / Sign up

Export Citation Format

Share Document