THE KINETICS OF THE DECOMPOSITION REACTIONS OF THE LOWER PARAFFINS: IV. THE ROLE OF FREE RADICALS IN THE DECOMPOSITION OF n-BUTANE

1939 ◽  
Vol 17b (3) ◽  
pp. 105-120 ◽  
Author(s):  
E. W. R. Steacie ◽  
H. O. Folkins
Keyword(s):  
Nitric Oxide ◽  
Ethylene Oxide ◽  
Complete Suppression ◽  
Radical Chain ◽  
Decomposition Reactions ◽  
Maximum Inhibition ◽  
A Chain ◽  
Kinetics Of ◽  
Oxide Inhibition

An investigation has been made of the inhibition of free radical chain processes in the decomposition of n-butane by the addition of nitric oxide. The method was to initiate chains in butane at low temperatures by means of ethylene oxide, and then to investigate the efficiency of nitric oxide in suppressing these chains.It was found that nitric oxide is not completely efficient as a chain breaker, inasmuch as sensitization by ethylene oxide persisted in the presence of large amounts of nitric oxide. It is therefore concluded that maximum inhibition of organic decomposition reactions by nitric oxide does not in all cases correspond to complete suppression of chains, and hence the real chain length in such reactions may be greater than that inferred from the results of the nitric oxide inhibition method.

THE KINETICS OF THE DECOMPOSITION REACTIONS OF THE LOWER PARAFFINS: VII. THE NITRIC OXIDE INHIBITED DECOMPOSITION OF ETHANE

1940 ◽  
Vol 18b (11) ◽  
pp. 351-357 ◽  
Author(s):  
E. W. R. Steacie ◽  
Gerald Shane
Keyword(s):  
Nitric Oxide ◽  
Activation Energy ◽  
Thermal Decomposition ◽  
Free Radical ◽  
Radical Chain ◽  
Decomposition Reactions ◽  
Rearrangement Mechanism ◽  
Chain Lengths ◽  
Kinetics Of

An investigation has been made of the nitric oxide inhibited thermal decomposition of ethane. Apparent chain lengths of 2.4 to 5 are found at temperatures from 640° to 565 °C. The activation energy of the inhibited reaction is found to be 77.3 Kcal. The results are discussed and it is concluded that the thermal decomposition of ethane proceeds mainly by a rearrangement mechanism and that free-radical chain mechanisms for the ethane decomposition are untenable.

Role of AT1 receptors in the renal papillary effects of acute and chronic nitric oxide inhibition

1998 ◽  
Vol 274 (3) ◽  
pp. R760-R766 ◽  
Author(s):  
M. Clara Ortíz ◽  
Lourdes A. Fortepiani ◽  
Francisco M. Ruiz-Marcos ◽  
Noemí M. Atucha ◽  
Joaquín García-Estañ
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Angiotensin Ii ◽  
Chronic Administration ◽  
Acute Administration ◽  
Synthesis Inhibitor ◽  
Renal Vasoconstriction ◽  
Oxide Inhibition ◽  
Stimulation Of

Nitric oxide (NO) is a vasodilator substance controlling renal papillary blood flow (PBF) in the rat. In this study we have evaluated the role of AT1 angiotensin II receptors as modulators of the whole kidney and papillary vasoconstrictor effects induced by the acute or chronic inhibition of NO synthesis. Experiments have been performed in anesthetized, euvolemic Munich-Wistar rats prepared for the study of renal blood flow (RBF) and PBF. In normal rats, acute administration of the NO synthesis inhibitor N ω-nitro-l-arginine methyl ester (l-NAME) increased mean arterial pressure (MAP) and decreased RBF and PBF. Either acute or chronic treatment with the AT1 receptor blocker losartan did not modify the decreases in RBF or PBF secondary to l-NAME. In animals made hypertensive by chronic inhibition of NO, basal MAP was higher, whereas RBF and PBF were lower than in the controls. In these animals, acute or chronic administration of losartan decreased MAP and increased both RBF and PBF significantly. These results indicate that, under normal conditions, the decreases in RBF or PBF induced by the acute inhibition of NO synthesis are not modulated by AT1-receptor stimulation. However, the arterial hypertension, renal vasoconstriction, and reduced PBF present in chronic NO-deficient hypertensive rats is partially due to the effects of angiotensin II, via stimulation of AT1-receptors.

Prominent role of NF-κB in the induction of endothelial activation by endogenous nitric oxide inhibition

Nitric Oxide ◽  
2009 ◽  
Vol 21 (3-4) ◽  
pp. 184-191 ◽  
Author(s):  
Guido Lazzerini ◽  
Serena Del Turco ◽  
Giuseppina Basta ◽  
Ana O’Loghlen ◽  
Antonella Zampolli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Activation ◽  
Nitric Oxide Inhibition ◽  
Endogenous Nitric Oxide ◽  
Oxide Inhibition

Role of Binding Site Loops in Controlling Nitric Oxide Release:  Structure and Kinetics of Mutant Forms of Nitrophorin 4†,‡

Biochemistry ◽  
2004 ◽  
Vol 43 (21) ◽  
pp. 6679-6690 ◽  
Author(s):  
Estelle M. Maes ◽  
Andrzej Weichsel ◽  
John F. Andersen ◽  
Donald Shepley ◽  
William R. Montfort
Keyword(s):  
Nitric Oxide ◽  
Binding Site ◽  
Nitric Oxide Release ◽  
Nitrophorin 4 ◽  
Mutant Forms ◽  
Kinetics Of

Role of prostanoids and nitric oxide inhibition in rats with experimental hepatic fibrosis

2000 ◽  
Vol 56 (3) ◽  
pp. 181-188 ◽  
Author(s):  
M. Criado ◽  
O. Flores ◽  
Ma J. Vázquez ◽  
A. Esteller
Keyword(s):  
Nitric Oxide ◽  
Hepatic Fibrosis ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

The thermal decomposition of aliphatic aldehydes

1963 ◽  
Vol 276 (1365) ◽  
pp. 278-292 ◽  
Keyword(s):  
Nitric Oxide ◽  
Thermal Decomposition ◽  
Chain Reaction ◽  
Chance Coincidence ◽  
Limited Success ◽  
Molecular Reaction ◽  
A Chain ◽  
The Stability ◽  
Oxide Inhibition ◽  
Chain Propagation And Termination

The thermal decomposition of acetaldehyde, propionaldehyde, n -butyraldehyde and iso-butyraldehyde, as investigated by the static method, is essentially homogeneous, inhibitable by propylene, isobutene and small amounts of nitric oxide, and generally catalyzed at high inhibitor concentrations. The kinetic order of the uninhibited decomposition exhibits little obvious regularity, but that of the maximally inhibited reaction is approximately 1.5 for all three inhibitors. Kates of the uninhibited decomposition do not follow the sequence in the homologous series, and there is no systematic variation in the extent of inhibition from one aldehyde to another. For each aldehyde, the minimum rates for the three inhibitors in general are not identical, nevertheless exhibit a correspondence probably close enough to eliminate chance coincidence. The kinetic and analytical results of the uninhibited decomposition can be approximately described by a Kice-Herzfeld-type mechanism, with the kinetics in each case largely determined by the stability of radicals and their reactions in chain propagation and termination. The question whether the maximally inhibited reaction is a molecular reaction or a chain reaction is surveyed. Although the results cannot be completely accounted for by a molecular reaction alone, a chain mechanism for propylene inhibition involving allyl radicals likewise has only limited success. For nitric-oxide inhibition, it is not certain how far the results are affected by the occurrence of the subsequent catalyzed reaction. No definite conclusion can thus be reached about the nature of the maximally inhibited reaction.

scholarly journals Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertension

2004 ◽  
Vol 89 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Juan Sáinz ◽  
Antonio Osuna ◽  
Rosemary Wangensteen ◽  
Juan de Dios Luna ◽  
Isabel Rodríguez-Gómez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Sex Hormones ◽  
Nitric Oxide Inhibition ◽  
Induced Hypertension ◽  
Oxide Inhibition
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