The concept of a system has a long and distinguished history in the social sciences. In fact, Mattelart and Mattelart (1998) claim that “the idea of society as an organism, that is, a whole composed of organs performing predetermined functions, inspired the earliest conceptions of a ‘science of communication’”. We begin this chapter with a brief historical overview of the major systems perspectives that have been utilized in social theory and research: structural-functionalism, cybernetics, and general systems theory. We then apply recent developments in complex systems theories to organizational networks. In doing so, we look at communication and knowledge networks from the perspective of agent-based modeling and self-organizing systems. Mattelart and Mattelart (1998) trace the early growth of systems thinking in the social sciences. Adam Smith’s (1776) classic work, The Wealth of Nations, postulated that a laissez-faire system, the division of labor, and channels of communication and transportation were crucial aspects of economic prosperity. The key to economic and therefore social success was the unrestricted circulation of messages, materials, and money through secure networks. According to Mattelart and Mattelart (1998), Francois Quesnay, a French physician and economist, published an economic chart (tableau economique) in 1758. “The chart offers a macroscopic vision of an economy of ‘flows’ in the form of a geometrical zigzag figure in which the lines expressing exchange between human beings and the land, as well as among the three classes making up society, cut across each other and become intertwined”. The Mattelarts note that Claude Henri de Saint Simon’s eighteenth-century work also applied systems theory to the concept of networks. Saint-Simons’s theory conceived of society as “an organic system, a bundle or fabric of networks.... He attributed strategic importance to the development of a system of communication routes”. Out of this background Herbert Spencer (1820–1903) developed the first integrated theory of society built on a direct analogy with biological systems.