Sequence of Sockeye Salmon Type 1 and 2 Growth Hormone Genes and the Relationship of Rainbow Trout with Atlantic and Pacific Salmon

1993 ◽  
Vol 50 (8) ◽  
pp. 1738-1748 ◽  
Author(s):  
Robert H. Devlin
Keyword(s):  
Growth Hormone ◽  
Rainbow Trout ◽  
Gene Duplication ◽  
Atlantic Salmon ◽  
Sockeye Salmon ◽  
Pacific Salmon ◽  
Duplication Event ◽  
Breeding Population ◽  
Gene Duplication Event ◽  
Relationship Of

Two types of growth hormone genes have been isolated from sockeye salmon (Oncorhynchus nerka) and their complete nucleotide sequence determined. The genes encode proteins of 210 amino acids and show considerable similarity to growth hormones characterized in other salmonids and fishes. The two genes presumably arose from a gene duplication event that generated the tetraploid condition in salmonids and are highly conserved in their coding regions. The sequences have diverged approximately 18% in noncoding regions since the gene duplication event and show numerous deletions and/or insertions. Isolation of these two genes from a Pacific salmon allows comparison of their sequences to growth hormone genes characterized from rainbow trout and from Atlantic salmon. The results indicate that rainbow trout is more similar to Pacific than to Atlantic salmon and suggest that Atlantic salmon diverged from Pacific salmonids at a time when sockeye and rainbow trout were part of a common breeding population. These results support the recent reclassification of rainbow trout from the genus Salmo to Oncorhynchus.

A new aminopeptidase from diamondback moth provides evidence for a gene duplication event in Lepidoptera

1999 ◽  
Vol 8 (2) ◽  
pp. 171-177 ◽  
Author(s):  
W. X. Z. Chang ◽  
L. J. Gahan ◽  
B. E. Tabashnik ◽  
D. G. Heckel
Keyword(s):  
Gene Duplication ◽  
Diamondback Moth ◽  
Duplication Event ◽  
Gene Duplication Event

scholarly journals Early Archean origin of heterodimeric Photosystem I

2017 ◽  
Author(s):  
Tanai Cardona
Keyword(s):  
Gene Duplication ◽  
Photosystem I ◽  
Water Oxidation ◽  
Duplication Event ◽  
Oxygenic Photosynthesis ◽  
Recent Common Ancestor ◽  
Type I ◽  
Reaction Centre ◽  
Gene Duplication Event ◽  
Most Recent Common Ancestor

AbstractWhen and how oxygenic photosynthesis originated remains controversial. Wide uncertainties exist for the earliest detection of biogenic oxygen in the geochemical record or the origin of water oxidation in ancestral lineages of the phylum Cyanobacteria. A unique trait of oxygenic photosynthesis is that the process uses a Type I reaction centre with a heterodimeric core, also known as Photosystem I, made of two distinct but homologous subunits, PsaA and PsaB. In contrast, all other known Type I reaction centres in anoxygenic phototrophs have a homodimeric core. A compelling hypothesis for the evolution of a heterodimeric Type I reaction centre is that the gene duplication that allowed the divergence of PsaA and PsaB was an adaptation to incorporate photoprotective mechanisms against the formation of reactive oxygen species, therefore occurring after the origin of water oxidation to oxygen. Here I show, using sequence comparisons and Bayesian relaxed molecular clocks that this gene duplication event may have occurred in the early Archean more than 3.4 billion years ago, long before the most recent common ancestor of crown group Cyanobacteria and the Great Oxidation Event. If the origin of water oxidation predated this gene duplication event, then that would place primordial forms of oxygenic photosynthesis at a very early stage in the evolutionary history of life.

Use of sequence data from rainbow trout and Atlantic salmon for SNP detection in Pacific salmon

2005 ◽  
Vol 14 (13) ◽  
pp. 4193-4203 ◽  
Author(s):  
CHRISTIAN T. SMITH ◽  
CARITA M. ELFSTROM ◽  
LISA W. SEEB ◽  
JAMES E. SEEB
Keyword(s):  
Rainbow Trout ◽  
Atlantic Salmon ◽  
Pacific Salmon ◽  
Sequence Data ◽  
Snp Detection

scholarly journals Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

2020 ◽  
Vol 94 (8) ◽  
Author(s):  
Akaash K. Mishra ◽  
Crystal L. Moyer ◽  
Dafna M. Abelson ◽  
Daniel J. Deer ◽  
Kamel El Omari ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Gene Duplication ◽  
Mouse Model ◽  
Hemorrhagic Fever ◽  
Duplication Event ◽  
Fever Virus ◽  
Gene Duplication Event ◽  
Protective Antibody ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

ABSTRACT Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of the most widespread tick-borne viral infection in humans. CCHFV encodes a secreted glycoprotein (GP38) of unknown function that is the target of a protective antibody. Here, we present the crystal structure of GP38 at a resolution of 2.5 Å, which revealed a novel fold primarily consisting of a 3-helix bundle and a β-sandwich. Sequence alignment and homology modeling showed distant homology between GP38 and the ectodomain of Gn (a structural glycoprotein in CCHFV), suggestive of a gene duplication event. Analysis of convalescent-phase sera showed high titers of GP38 antibodies indicating immunogenicity in humans during natural CCHFV infection. The only protective antibody for CCHFV in an adult mouse model reported to date, 13G8, bound GP38 with subnanomolar affinity and protected against heterologous CCHFV challenge in a STAT1-knockout mouse model. Our data strongly suggest that GP38 should be evaluated as a vaccine antigen and that its structure provides a foundation to investigate functions of this protein in the viral life cycle. IMPORTANCE Crimean-Congo hemorrhagic fever virus (CCHFV) is a priority pathogen that poses a high risk to public health. Due to the high morbidity and mortality rates associated with CCHFV infection, there is an urgent need to develop medical countermeasures for disease prevention and treatment. CCHFV GP38, a secreted glycoprotein of unknown function unique to the Nairoviridae family, was recently shown to be the target of a protective antibody against CCHFV. Here, we present the crystal structure of GP38, which revealed a novel fold with distant homology to another CCHFV glycoprotein that is suggestive of a gene duplication event. We also demonstrate that antibody 13G8 protects STAT1-knockout mice against heterologous CCHFV challenge using a clinical isolate from regions where CCHFV is endemic. Collectively, these data advance our understanding of GP38 structure and antigenicity and should facilitate future studies investigating its function.

IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE

1963 ◽  
Vol 41 (4) ◽  
pp. 875-887 ◽  
Author(s):  
D. R. Idler ◽  
B. Truscott ◽  
H. C. Freeman ◽  
V. Chang ◽  
P. J. Schmidt ◽  
...  
Keyword(s):  
Atlantic Salmon ◽  
Sockeye Salmon ◽  
Pacific Salmon ◽  
In Vivo Metabolism ◽  
Hormone Metabolism ◽  
The Pacific ◽  
Imminent Death ◽  
High Concentrations ◽  
Sexually Mature

Intra-arterially injected cortisone-4-C14 and cortisol-4-C14 were cleared from the plasma of sexually mature and spawned sockeye salmon (O. nerka) at a much slower rate than from the plasma of immature sockeye and spawned Atlantic salmon (S. salar). The results explain the elevated hormone levels found in the blood of mature and spawned sockeye salmon. The normal clearance rate found with Atlantic salmon, which frequently survive spawning, would indicate that the impaired hormone metabolism was associated with the imminent death of the Pacific salmon rather than with the act of spawning.Testosterone and 17α-hydroxyprogesterone were found to be precursors of 11-ketotestosterone, a sex hormone found in high concentrations in the blood of mature sockeye salmon. Testosterone was also formed in vivo from 17α-hydroxyprogesterone. The results suggest more than one pathway for the synthesis of 11-ketotestosterone in salmon. Cortisol was converted to cortisone but no conversion of the former to 11-ketotestosterone could be demonstrated.

IN VIVO METABOLISM OF STEROID HORMONES BY SOCKEYE SALMON: (A) IMPAIRED HORMONE CLEARANCE IN MATURE AND SPAWNED PACIFIC SALMON (O. NERKA) (B) PRECURSORS OF 11-KETOTESTOSTERONE

1963 ◽  
Vol 41 (1) ◽  
pp. 875-887
Author(s):  
D. R. Idler ◽  
B. Truscott ◽  
H. C. Freeman ◽  
V. Chang ◽  
P. J. Schmidt ◽  
...  
Keyword(s):  
Atlantic Salmon ◽  
Sockeye Salmon ◽  
Pacific Salmon ◽  
In Vivo Metabolism ◽  
Hormone Metabolism ◽  
The Pacific ◽  
Imminent Death ◽  
High Concentrations ◽  
Sexually Mature

Intra-arterially injected cortisone-4-C14 and cortisol-4-C14 were cleared from the plasma of sexually mature and spawned sockeye salmon (O. nerka) at a much slower rate than from the plasma of immature sockeye and spawned Atlantic salmon (S. salar). The results explain the elevated hormone levels found in the blood of mature and spawned sockeye salmon. The normal clearance rate found with Atlantic salmon, which frequently survive spawning, would indicate that the impaired hormone metabolism was associated with the imminent death of the Pacific salmon rather than with the act of spawning.Testosterone and 17α-hydroxyprogesterone were found to be precursors of 11-ketotestosterone, a sex hormone found in high concentrations in the blood of mature sockeye salmon. Testosterone was also formed in vivo from 17α-hydroxyprogesterone. The results suggest more than one pathway for the synthesis of 11-ketotestosterone in salmon. Cortisol was converted to cortisone but no conversion of the former to 11-ketotestosterone could be demonstrated.

scholarly journals Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Madhuri A. Inupakutika ◽  
Soham Sengupta ◽  
Rachel Nechushtai ◽  
Patricia A. Jennings ◽  
Jose’ N. Onuchic ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Gene Duplication ◽  
Duplication Event ◽  
Gene Duplication Event

scholarly journals Sequences encoding two trypsin inhibitors occur in strikingly similar genomic environments

1986 ◽  
Vol 233 (2) ◽  
pp. 443-450 ◽  
Author(s):  
I B Kingston ◽  
S Anderson
Keyword(s):  
Gene Duplication ◽  
Trypsin Inhibitor ◽  
Bovine Genome ◽  
Duplication Event ◽  
The Other ◽  
Bovine Pancreatic Trypsin Inhibitor ◽  
Gene Duplication Event ◽  
Coding Region ◽  
Pancreatic Trypsin Inhibitor ◽  
Putative Intron

The nucleotide sequences of two approx. 4 kilobase pair segments of the bovine genome are presented. One segment contains a coding region for bovine pancreatic trypsin inhibitor (BPTI) and the other segment contains a coding region for a BPTI homologue. The two 4 kilobase pair sequences are strikingly similar over approx. 3.4 kilobase pairs of their sequence, including putative intron sequences, suggesting that they have evolved from a gene duplication event.

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