A tosyliminium ion-based total synthesis of (±)-schefferine
The synthesis of the phenolic tetrahydroprotoberberine alkaloid (±)-schefferine is reported, featuring as key steps a tosyliminium ion-mediated Friedel-Crafts alkylation of eugenol dimethyl ether and an intramolecular Mitsunobu-type amination.Key words: total synthesis, (±)-schefferine, natural product, tosyliminium ion, Mitsunobu amination.
2018 ◽
Vol 13
(7)
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pp. 1934578X1801300
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2001 ◽
Vol 79
(11)
◽
pp. 1562-1592
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