The Kinetic Activation Volumes for the Binding of Iodide to Cobalamin (Vitamin B12) Studied on a High Pressure Laser Temperature Jump Apparatus
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The relaxation kinetics of the reaction of iodide with cobalamin (vitamin B12) were studied on a high pressure laser temperature jump apparatus in aqueous solution at 25° and ionic strength 0.2 M. Analysis of the pressure dependence of the formation and dissociation rate constants gave their respective volumes of activation to be: ΔVf* = 5.50 ± 0.8 cm3 mol−1 and ΔVd* = 11.5 ± 1.6 cm3 mol−1 The positive activation volume for formation of the complex, ΔVf*, after appropriate correction for the volume change due to formation of an outer sphere complex, is consistent with a dissociative type mechanism in which the metal ion – water bond is stretched in the activated complex.
1976 ◽
Vol 72
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pp. 1362
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1976 ◽
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pp. 1820-1826
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2006 ◽
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pp. 615-627
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1988 ◽
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pp. 2807
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2018 ◽
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pp. 4146-4151
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1982 ◽
Vol 47
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pp. 1773-1779
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