Antagonism by phosphate buffer of the twitch loss in isolated muscle fibers produced by calcium-free solutions
1978 ◽
Vol 56
(3)
◽
pp. 523-526
◽
Keyword(s):
In 37 of 41 isolated frog skeletal muscle fiber preparations (one, two, or three fibers) the twitch was eliminated or reduced to < 10% of control by exposing the fibers to a 0-caicium, bicarbonate-buffered solution for 10 min or less. Replacing the bicarbonate by a phosphate buffer either prevented twitch inhibition or increased the 0-calcium exposure time required for its production. It is concluded that surface membrane-bound calcium ions (presumably in the t-tubules) are required to couple the action potential to the mechanical response and that phosphate ions inhibit the loss of the membrane-bound calcium ions into an external calcium-free solution.
1974 ◽
Vol 32
◽
pp. 154-155
Keyword(s):
2009 ◽
Vol 610-613
◽
pp. 1391-1394
Keyword(s):
1988 ◽
Vol 66
(9)
◽
pp. 1210-1213
◽
1966 ◽
Vol 62
(4)
◽
pp. 1089-1092
Keyword(s):
1995 ◽
Vol 85
(2)
◽
pp. 181-186
◽
Keyword(s):
EXTERNAL CALCIUM IONS AND MECHANICAL RESPONSES OF THE AORTA ISOLATED FROM THE CHOLESTEROL-FED RABBIT
1974 ◽
Vol 24
(1)
◽
pp. 167-169
◽
Keyword(s):
2006 ◽
Vol 35
(4)
◽
pp. 285-293
◽
1980 ◽
Vol 64
(4)
◽
pp. 357-360
◽