Improved carbohydrate tolerance in fibre-fed rats: studies of the chronic effect

1982 ◽  
Vol 60 (6) ◽  
pp. 769-776 ◽  
Author(s):  
Norman S. Track ◽  
Marilyn M. Cannon ◽  
Ann Flenniken ◽  
Stefa Katamay ◽  
Edward F. A. Woods
Keyword(s):  
Weight Gain ◽  
Glucose Uptake ◽  
Dietary Fibre ◽  
Chronic Effect ◽  
Carbohydrate Tolerance ◽  
Liquid Meal ◽  
Postprandial Plasma Glucose ◽  
Low Carbohydrate ◽  
Uptake Activity ◽  
Different Sources

The effect of chronic consumption of diets containing either different sources of dietary fibre (8% guar, 8% pectin, or 8% multifibre) or low carbohydrate upon carbohydrate tolerance was examined in rats. Weight gain was significantly lower throughout the entire 28-day study period with the guar group and after 20 days with the multifibre group. When tested with a liquid meal (1 g sucrose/kg body weight) after 14 days on the diets, only the guar rats had significantly lower fasting and postprandial plasma glucose concentrations. After 28 days, the improved carbohydrate tolerance persisted in the guar rats and started to appear in the multifibre rats. Pectin and low carbohydrate diets had no effect upon either weight gain or carbohydrate tolerance. Consuming the fibre diets did not affect jejunal sucrase activities. Jejunal glucose uptake activity was significantly diminished when measured in fasting guar rats while postprandially activities were similar to controls. Jejunal Na-K-ATPase activities in fasting and postprandial guar rats were not related to changes in glucose uptake. These studies confirm that only certain types of dietary fibre improve carbohydrate tolerance and suggest that reduced weight gain and altered intestinal glucose uptake are factors involved in the chronic fibre effect.

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

2020 ◽  
Vol 17 (7) ◽  
pp. 840-849
Author(s):  
Mahendra Gowdru Srinivas ◽  
Prabitha Prabhakaran ◽  
Subhankar Probhat Mandal ◽  
Yuvaraj Sivamani ◽  
Pranesh Guddur ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Molecular Design ◽  
Docking Studies ◽  
Antidiabetic Activity ◽  
Design Synthesis ◽  
In Silico Docking ◽  
Ppar Γ ◽  
Sar Studies ◽  
Structure Activity ◽  
Uptake Activity

Background: Thiazolidinediones and its bioisostere, namely, rhodanines have become ubiquitous class of heterocyclic compounds in drug design and discovery. In the present study, as part of molecular design, a series of novel glitazones that are feasible to synthesize in our laboratory were subjected to docking studies against PPAR-γ receptor for their selection. Methods and Results: As part of the synthesis of selected twelve glitazones, the core moiety, pyridine incorporated rhodanine was synthesized via dithiocarbamate. Later, a series of glitazones were prepared via Knovenageal condensation. In silico docking studies were performed against PPARγ protein (2PRG). The titled compounds were investigated for their cytotoxic activity against 3T3-L1 cells to identify the cytotoxicity window of the glitazones. Further, within the cytotoxicity window, glitazones were screened for glucose uptake activity against L6 cells to assess their possible antidiabetic activity. Conclusion: Based on the glucose uptake results, structure activity relationships are drawn for the title compounds.

In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes

Phytomedicine ◽  
2006 ◽  
Vol 13 (6) ◽  
pp. 434-441 ◽  
Author(s):  
R. Anandharajan ◽  
S. Jaiganesh ◽  
N.P. Shankernarayanan ◽  
R.A. Viswakarma ◽  
A. Balakrishnan
Keyword(s):  
Glucose Uptake ◽  
Pi3 Kinase ◽  
Syzygium Cumini ◽  
Glut 4 ◽  
L6 Myotubes ◽  
Uptake Activity

scholarly journals Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

2008 ◽  
Vol 56 (8) ◽  
pp. 1181-1183 ◽  
Author(s):  
Midori Nishide ◽  
Yutaka Yoshikawa ◽  
Eriko U. Yoshikawa ◽  
Kinuyo Matsumoto ◽  
Hiromu Sakurai ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Glucose Uptake ◽  
Rat Adipocytes ◽  
Uptake Activity ◽  
Isolated Rat

scholarly journals Hypothesis on the glucose production’s communication model between thebrain and other internal organs, especially the stomach and liver

2020 ◽  
Keyword(s):  
Glucose Production ◽  
Internal Communication ◽  
Cooking Methods ◽  
Communication Model ◽  
Internal Organs ◽  
Continuous Glucose Monitor ◽  
Solid Meal ◽  
Liquid Meal ◽  
Postprandial Plasma Glucose ◽  
Lower Glucose

After reviewing the research results for six months, from September 2019 through February 2020, the author identified a probable internal communication model between the nervous system and certain vital internal organs, specifically the stomach and liver regarding postprandial plasma glucose (PPG) production. The author used a continuous glucose monitor device to collect 50,000 glucose data during the past 665 days. He focused on studying the relationships among different food nutritional contents, cooking methods, food material’s physical phases, and different characteristics and variants from his glucose waveform patterns. In this study, he focused on the three major meal groups based on food nutritional ingredients, meal’s preparation, and cooking methods of eggs, squash, and cabbage to create soup-based (liquid) meal and pan-fried (solid) meal. The PPG waveforms from these three meal groups demonstrated that soup-based liquid food produced a much lower glucose value than the pan-fried solid food. Although both liquid and solid meals have similar identical nutritional ingredients, he questions why did this occur? His hypothesis is that his PPG differences are due to specific physical phase of his finished meal either “liquid” or “solid”, which is his ready-to-eat meal’s final physical “phase” that determines his PPG characteristics and waveforms. The author utilized his GH-Method: math-physical medicine (MPM) approach to explore a T2D patient’s glucose production situation from a scientific view of the brain and nervous system’s functionalities. If this specific approach and above interpretation are accurate, we can then “trick” our brain into producing a “lesser” amount of glucose after food intake without altering or sacrificing the needed food nutritional balance. As a result, T2D patients can simply change their cooking method in order to lower both of their peak PPG values and their average PPG levels.

scholarly journals Hypoglycemic Effect of Vitexin in C57BL/6J Mice and HepG2 Models

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Weidong Xu ◽  
Jiayao Li ◽  
Weipeng Qi ◽  
Ye Peng
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Glucose Uptake ◽  
Lipid Content ◽  
Hepg2 Cells ◽  
Body Weight Gain ◽  
Tnf Α ◽  
Hepatic Lipid Content

Apigenin-8-C-glucoside (vitexin), a natural phytochemical contained in hawthorn, has been reported to have versatile beneficial bioactivities, such as antioxidation, anticancer property, and adipogenesis inhibition. The present research aimed to determine the influence of vitexin on insulin resistance elicited by HFD in mice and HepG2 cells. Vitexin markedly alleviated body weight gain and improved glucose and insulin intolerance induced by HFD. Vitexin partially normalized blood glucose, cholesterol, TNF-α, and hepatic lipid content. Moreover, vitexin recovered the reduced glucose uptake induced by glucosamine. The present results indicate that vitexin prevents HFD-induced insulin resistance.

scholarly journals Performance of Broilers Fed Diets Supplemented With Graded Levels of Soybean Oil and Different Sources of Bone Meal

2016 ◽  
Vol 4 (3) ◽  
pp. 272-280
Author(s):  
Surya Prasad Tiwari ◽  
Maheshwor Sapkota ◽  
Dainik Bahadur Nepali ◽  
Jagat Lal Yadav ◽  
Geeta Jamarkattel Tiwari
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Soybean Oil ◽  
Body Weight Gain ◽  
Feed Consumption ◽  
Bone Meal ◽  
Weight Percentage ◽  
Calcium Phosphorus ◽  
Different Sources ◽  
Average Body

An experiment was conducted to investigate the effects of inclusion of three levels of soybean oil (0%, 2% and 4%) and three sources of commercial bone meals (GBM, PBM and IBM) in the diet of broiler chicken. Body weight, weight gain, feed consumption, feed efficiency, digestibility coefficient, calcium, phosphorus and ash content of blood and bone of broilers were measured. Significantly higher (P<0.01) average weekly feed consumption, average cumulative body weight, average weekly body weight gain was found in broilers fed diets containing soybean oil. The highest (5058.27 g) average total feed consumption was recorded on T9 and the lowest (4117.88 g) on T1. The highest average cumulative body weight was obtained on T6 (2168.33 g) and was the lowest on T1 (1930.00 g). Similarly, the highest average body weight gain was recorded on T6 (301.04 g) and the lowest on T1 (273.77 g). The abdominal fat weight percentage was maximum (2.38%) on the diet containing 4% soybean oil with GBM and minimum (1.04%) on the diet without soybean oil withIBM. However, the overall performance of broilers was found improved on the diet containing soybean oil. The ash, calcium and phosphorus content of blood and bone were better when supplied the diet with 2% to 4% soybean oil containing the sources of bone meal. Considering better bone calcification, phosphorus and minerals utilization in the chicken body, 2% to 4% levels of the soybean oil with the GBM source of bone meal could be incorporated in the diets. Int J Appl Sci Biotechnol, Vol 4(3): 272-280

scholarly journals Regulation of energy expenditure and substrate oxidation by short-chain fatty acids

2019 ◽  
Vol 242 (2) ◽  
pp. R1-R8 ◽  
Author(s):  
Alia H Sukkar ◽  
Aaron M Lett ◽  
Gary Frost ◽  
Edward S Chambers
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Lipid Oxidation ◽  
Dietary Fibre ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Present Review

Short-chain fatty acids (SCFAs) are metabolites produced from the fermentation of dietary fibre by the gut microbiota. High-fibre diets have been associated with lower weight gain and a number of reports have therefore investigated if these positive effects of a dietary fibre on body weight can be replicated through the direct administration of SCFAs. Many of these studies have reported that SCFAs can prevent or attenuate long-term body weight gain by increasing energy expenditure through increased lipid oxidation. The aim of the present review is to therefore evaluate the current evidence for an effect of SCFAs on whole-body energy expenditure and to assess the potential underlying mechanisms. The available data highlights that SCFAs can exert multiple effects at various organ and tissue sites that would cumulatively raise energy expenditure via a promotion of lipid oxidation. In conclusion, the present review proposes that dietary interventions and other therapies that augment gut-derived SCFAs and systemic availability may present an effective strategy to improve long-term energy balance and body weight management.

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