Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit
1995 ◽
Vol 73
(6)
◽
pp. 714-717
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Keyword(s):
The purpose of the present study was to examine the effect of intravenous administration of propofol and thiopentone on picrotoxin-induced seizures using the picrotoxin convulsive threshold test in the rabbit. Neither propofol nor thiopentone at a dose of 1.25 mg/kg had any significant effect on picrotoxin seizure threshold. However, at higher doses (2.5, 5, 10 mg/kg) both propofol and thiopentone produced a significant and dose-dependent increase in the picrotoxin convulsive threshold. These findings suggest that propofol is an effective anticonvulsant against picrotoxin-induced seizures in the rabbit.Key words: convulsions, intravenous anesthetics, picrotoxin, propofol, thiopentone.
1995 ◽
Vol 269
(6)
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pp. H1955-H1964
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1988 ◽
Vol 255
(6)
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pp. F1230-F1234
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Keyword(s):
1990 ◽
Vol 18
(01n02)
◽
pp. 71-76
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1975 ◽
Vol 142
(6)
◽
pp. 1462-1476
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Keyword(s):
1999 ◽
Vol 81
(04)
◽
pp. 594-560
◽
1989 ◽
Vol 61
(03)
◽
pp. 463-467
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Keyword(s):