Genetic Mapping of Human Immune System Function

Idiopathic chronic inflammatory conditions (ICIC) such as allergy, asthma, chronic obstructive pulmonary disease, and various autoimmune conditions are a worldwide health problem. Understanding the pathogenesis of ICIC is essential for their successful therapy and prevention. However, efforts are hindered by the lack of comprehensive understanding of the human immune system function. In line with those efforts, described here is a concept of stochastic continuous dual resetting (CDR) of the immune repertoire as a basic principle that governs the function of immunity. The CDR functions as a consequence of system’s thermodynamically determined intrinsic tendency to acquire new states of inner equilibrium and equilibrium against the environment. Consequently, immune repertoire undergoes continuous dual (two-way) resetting: against the physiologic continuous changes of self and against the continuously changing environment. The CDR-based dynamic concept of immunity describes mechanisms of self-regulation, tolerance, and immunosenescence, and emphasizes the significance of immune system’s compartmentalization in the pathogenesis of ICIC. The CDR concept’s relative simplicity and concomitantly documented congruency with empirical, clinical, and experimental data suggest it may represent a plausible theoretical framework to better understand the human immune system function.

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The Effect of Consuming Food Allergens on Immune System Function with the Focus on Infectious Lung Diseases (COVID-19)

Traditional and Integrative Medicine ◽

10.18502/tim.v6i1.5928 ◽

2021 ◽

Author(s):

Mohammad Kamalinejad ◽

Razieh Nabimeybodi ◽

Rahele Zareshahi ◽

Naeeme Nabimeybodi

Keyword(s):

Immune System ◽

Lung Diseases ◽

Respiratory Diseases ◽

Causes Of Death ◽

Interleukin 4 ◽

Inflammatory Factors ◽

Human Immune System ◽

Nutritional Factors ◽

Immune System Function ◽

Human Immune

The pandemics of respiratory diseases are the most common ones comparing to other diseases. The latest pandemic is caused by COVID-19, for which no definitive cure has been found. Therefore, at present, strengthening the immune system is the only way to protect humans against this virus. Food is one of the factors assisting the immune system to function properly. Moreover, food plays an important role in strengthening the immune system against various pathogens. However, many popular sources of human food, including legumes, eggs, and nuts, contain anti-nutritional factors that can adversely affect the human immune system and increase inflammatory factors such as interleukin 4 and interleukin 6. A cytokine storm and increased secretion of interleukin 4 and 6 are among the most frequent causes of death in COVID-19 patients. Consequently, taking the COVID-19 patient’s diets into account by considering the foods influencing their immune system can greatly reduce the disease’s severity and mortality rate.

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EFFECT OF PETTING A DOG ON IMMUNE SYSTEM FUNCTION

Psychological Reports ◽

10.2466/pr0.95.7.1087-1091 ◽

2004 ◽

Vol 95 (7) ◽

pp. 1087 ◽

Cited By ~ 14

Author(s):

CARL J. CHARNETSKI

Keyword(s):

Immune System ◽

System Function ◽

Immune System Function

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Faculty Opinions recommendation of The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725390605.793505391 ◽

2015 ◽

Author(s):

Toshihiro Nakajima ◽

Satoko Aratani

Keyword(s):

Immune System ◽

Genetic Architecture ◽

Human Immune System ◽

Disease Pathogenesis ◽

System A ◽

Human Immune

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721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-sitc2020.0721 ◽

2020 ◽

Vol 8 (Suppl 3) ◽

pp. A763-A763

Author(s):

Remko Schotte ◽

Julien Villaudy ◽

Martijn Kedde ◽

Wouter Pos ◽

Daniel Go ◽

...

Keyword(s):

T Cells ◽

Immune System ◽

T Cell ◽

Tumor Cells ◽

Tumor Rejection ◽

Human Immune System ◽

Preclinical Development ◽

High Affinity ◽

Human Immune ◽

A375 Melanoma

BackgroundAdaptive immunity to cancer cells forms a crucial part of cancer immunotherapy. Recently, the importance of tumor B-cell signatures were shown to correlate with melanoma survival. We investigated whether tumor-targeting antibodies could be isolated from a patient that cured (now 13 years tumor-free) metastatic melanoma following adoptive transfer of ex vivo expanded autologous T cells.MethodsPatient‘s peripheral blood B cells were isolated and tested for the presence of tumor-reactive B cells using AIMM’s immmortalisation technology. Antibody AT1412 was identified by virtue of its differential binding to melanoma cells as compared to healthy melanocytes. AT1412 binds the tetraspanin CD9, a broadly expressed protein involved in multiple cellular activities in cancer and induces ADCC and ADCP by effector cells.ResultsSpontaneous immune rejection of tumors was observed in human immune system (HIS) mouse models implanted with CD9 genetically-disrupted A375 melanoma (A375-CD9KO) tumor cells, while A375wt cells were not cleared. Most notably, no tumor rejection of A375-CD9KO tumors was observed in NSG mice, indicating that blockade of CD9 makes tumor cells susceptible to immune rejection.CD9 has been described to regulate integrin signaling, e.g. LFA-1, VLA-4, VCAM-1 and ICAM-1. AT1412 was shown to modulate CD9 function by enhancing adhesion and transmigration of T cells to endothelial (HUVEC) cells. AT1412 was most potently enhancing transendothelial T-cell migration, in contrast to a high affinity version of AT1412 or other high affinity anti-CD9 reference antibodies (e.g. ALB6). Enhanced immune cell infiltration is also observed in immunodeficient mice harbouring a human immune system (HIS). AT1412 strongly enhanced CD8 T-cell and macrophage infiltration resulting in tumor rejection (A375 melanoma). PD-1 checkpoint blockade is further sustaining this effect. In a second melanoma model carrying a PD-1 resistant and highly aggressive tumor (SK-MEL5) AT1412 together with nivolumab was inducing full tumor rejection, while either one of the antibodies alone did not.ConclusionsThe safety of AT1412 has been assessed in preclinical development and is well tolerated up to 10 mg/kg (highest dose tested) by non human primates. AT1412 demonstrated a half-life of 8.5 days, supporting 2–3 weekly administration in humans. Besides transient thrombocytopenia no other pathological deviations were observed. No effect on coagulation parameters, bruising or bleeding were observed macro- or microscopically. The thrombocytopenia is reversible, and its recovery accelerated in those animals developing anti-drug antibodies. First in Human clinical study is planned to start early 2021.Ethics ApprovalStudy protocols were approved by the Medical Ethical Committee of the Leiden University Medical Center (Leiden, Netherlands).ConsentBlood was obtained after written informed consent by the patient.

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Effects of Long-Term Supplementation of Bovine Colostrum on the Immune System in Young Female Basketball Players. Randomized Trial

Nutrients ◽

10.3390/nu13010118 ◽

2020 ◽

Vol 13 (1) ◽

pp. 118

Author(s):

Anna Skarpańska-Stejnborn ◽

Mirosława Cieślicka ◽

Hanna Dziewiecka ◽

Sławomir Kujawski ◽

Anita Marcinkiewicz ◽

...

Keyword(s):

Immune System ◽

Physical Exercise ◽

Exercise Program ◽

Bovine Colostrum ◽

Control Group ◽

System Function ◽

Basketball Players ◽

Immune System Function ◽

Experimental Group

An intensive physical exercise program could lead to a decrease in immune system function. Effects of long-term supplementation of bovine colostrum on the response of immune function on physical exercise test in athletes were examined. Twenty-seven elite female basketball players (age 16–19) were randomly assigned to either an experimental group or a control group. Eventually, n = 11 athletes completed intervention in the experimental group (3.2 g bovine colostrum orally twice a day for 24 weeks), while n = 9 athletes in the control group were given a placebo. Before the supplementation, after 3 and 6 months, subjects performed the physical exercise stress test. Before, just after, and 3 h after physical exercise testing, blood was drawn and immune system indicators were examined. Plasma interleukin (IL)-1alpha, IL-2, IL-10, IL-13, tumor necrosis factor (TNF) alpha, creatine kinase (CK MM), immunoglobulin G (IgG), insulin-like growth factor 1 (IGF1), and WBC, lymphocyte (LYM), monocyte (MON), and granulocyte (GRA) were measured. A statistically significant change in IL-10 in response to the exercise program during the supplementation period in both groups was observed (p = 0.01). However, the results of the rest of the comparisons were statistically insignificant (p > 0.05). Contrary to our initial hypothesis, there were no significant effects of bovine supplementation on the dynamics of immune system function indicators.

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