Wu-Ling-San Formula Inhibits the Crystallization of Calcium Oxalate In Vitro

2007 ◽  
Vol 35 (03) ◽  
pp. 533-541 ◽  
Author(s):  
Yu-Cheng Chen ◽  
Chien-Yi Ho ◽  
Lieh-Der Chen ◽  
Sheng-Feng Hsu ◽  
Wen-Chi Chen
Keyword(s):  
Calcium Oxalate ◽  
Urinary Stone ◽  
Stone Disease ◽  
Crystal Nucleation ◽  
Urinary Stones ◽  
Common Disease ◽  
Urinary Stone Disease ◽  
Long Term Treatment

Urinary stone disease is a common disease and has a high rate of recurrence. There is no ideal long-term medical treatment to prevent the recurrence of urinary stones. Wu-Ling-San (WLS) formula has been used for centuries in China for long-term treatment of urological diseases. However, no pharmacological studies have been conducted to evaluate its effect on urinary stone disease. Therefore, using a photospectrometer, we studied the effects of WLS on nucleation, growth and aggregation of calcium oxalate in vitro. The results showed that WLS extract significantly slowed the speed of calcium oxalate ( CaOx ) crystal nucleation. WLS extracts at concentrations of 6.25, 12.5, 25, and 50 mg/ml inhibited nucleation of calcium oxalate crystallization by 344, 387, 543, and 943%, respectively. WLS extracts did not inhibit the growth of CaOx crystallization; however, WLS extracts at concentrations of 12.5 and 25 mg/ml significantly inhibited the aggregation of CaOx crystallization by 74.24% and 75.05%, respectively. WLS extract at a concentration of 50 mg/ml inhibited CaOx aggregation by 92.49%. In conclusion, our results indicate that WLS extract inhibited calcium oxalate nucleation and aggregation, and may have the potential to prevent stone recurrence.

scholarly journals Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease

2020 ◽  
Vol 3 (3) ◽  
pp. 179-189
Author(s):  
Saurabh Nimesh ◽  
Vrish Dhwaj Ashwlayan ◽  
Rubi Rani ◽  
Om Prakash
Keyword(s):  
Urinary Tract ◽  
Side Effects ◽  
Herbal Medicines ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Common Disease ◽  
Herbal Therapy ◽  
Urinary Stone Disease ◽  
Based Medicine

Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.

scholarly journals Open Surgery for Urinary Stones in a Resource Poor Setting: A Look at Dalhatu Araf Specialist Hospital, Lafia, Nigeria

2021 ◽  
Vol 2 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Christian Agbo
Keyword(s):  
Open Surgery ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Endoscopic Management ◽  
Resource Poor Setting ◽  
Cost Of Treatment ◽  
Urinary Stone Disease ◽  
Resource Poor ◽  
The Cost

Urinary stone disease has afflicted humankind since antiquity[1]. It remains a common urological condition worldwide, including in our environment[2]. Although open surgery was previously the main option for stone removal, advances in technology mean that treatment is now largely through minimally invasive surgery, as recommended by a number of urological guidelines[3,4]. Unfortunately, at our centre, we still treat urinary stones solely through open surgery, mostly because we lack endoscopic equipment. In addition, most of our patients, even if referred to facilities where endoscopic management is possible, cannot afford the cost of treatment.

scholarly journals URINARY STONE COMPOSITION ANALYSIS IN INDONESIAN POPULATION: A SINGLE MAJOR CENTRE ANALYSIS

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Her Bayu Widyasmara ◽  
Ponco Birowo ◽  
Nur Rasyid
Keyword(s):  
Calcium Oxalate ◽  
Urinary Stone ◽  
Stone Disease ◽  
Composition Analysis ◽  
Stone Composition ◽  
Female Ratio ◽  
Urinary Stone Disease ◽  
Indonesian Population ◽  
Male Female Ratio ◽  
Stone Type

Objective: To evaluate the urinary stone composition of Indonesian population. Material & Methods: This is a retrospective study analyzing total 277 urinary stone, obtained from urinary stone patient that underwent treatment in Cipto Mangunkusumo Hospital Jakarta in period 2000-2013. Results: Urinary stone disease is more common in male, with male : female ratio 1.8 : 1, with both in male and female patient, the incidence are highest at 51-60 years old. Calcium containing stone is predominant in this study with calcium oxalate as the most frequent stone with 61% overall, 43.7% in male and 17.3% in female and founded most frequent in 51-60 years old. Uric acid become the second most common stone after calcium containing stone with 9.0% overall, 6.5% in male and 2.5% in female. Infection associated stone such as struvite is 5.8% and Amonium urate 0.7%. In our study, struvite is founded more in male 3.6% than in female 2.2%. Cystine is a rare stone which is only founded 0.7%, in young age at 21-30 years old. Conclusion: Calcium oxalate is the most frequently stone type in our country as it is worldwide. This study revealed  information of stone composition in Indonesian population, that could be beneficial for strategies and management to prevent urinary stone disease and recurrence.  

scholarly journals APLICAREA TEHNOLOGIEI LASER HOLMIUM ÎN TRATAMENTUL LITIAZEI RENOURETERALE

InterConf ◽  
2021 ◽  
pp. 294-301
Author(s):  
Dinari Cojocaru
Keyword(s):  
Endoscopic Treatment ◽  
New Technologies ◽  
Urinary Stone ◽  
Laser Lithotripsy ◽  
Stone Disease ◽  
Holmium Laser ◽  
Urinary Stones ◽  
Urinary Stone Disease ◽  
Substantial Role ◽  
Progressive Development

The efficiency and safety of the Holmium Laser has made this method of treatment a versatile multi-purpose instrument for use in the endoscopic treatment for variety of urologic disorders, in particular urinary stones. According to progressive development of new technologies - current endourologic laser lithotripsy applications, for treatment of urinary stone disease has a substantial role for urologist practitioner.

scholarly journals Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128374 ◽  
Author(s):  
David W. Killilea ◽  
Jodi L. Westropp ◽  
Ryoji Shiraki ◽  
Matthew Mellema ◽  
Jennifer Larsen ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Canine Model ◽  
Urinary Stone ◽  
Stone Disease ◽  
Elemental Content ◽  
Urinary Stone Disease ◽  
Calcium Oxalate Stones

scholarly journals Pathogenesis of calcium oxalate urinary stone disease: species comparison of humans, dogs, and cats

Urolithiasis ◽  
2017 ◽  
Vol 45 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Allison L. O’Kell ◽  
David C. Grant ◽  
Saeed R. Khan
Keyword(s):  
Calcium Oxalate ◽  
Urinary Stone ◽  
Stone Disease ◽  
Species Comparison ◽  
Urinary Stone Disease

scholarly journals A 13 year hospital based study on the Trend of Urinary Stone Disease in Uttarakhand, India

2021 ◽  
Vol 11 (1) ◽  
pp. 949-958
Author(s):  
Monica Kakkar ◽  
Rakesh Kakkar
Keyword(s):  
Retrospective Study ◽  
Renal Stones ◽  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stones ◽  
Religious Groups ◽  
Medical Sciences ◽  
Urinary Stone Disease ◽  
Disease Site ◽  
Keywords Urolithiasis

Background: The present retrospective study on urinary stone disease in the Uttarakhand state was necessitated as no study has been done yet. Methods: A retrospective study covering a period of about 13 years (2005-18) was conducted on the urinary stones removed from the patients, admitted at Himalayan Institute of Medical Sciences, Dehradun. The incidence of the disease, site of stones in urinary tract upon diagnosis, composition of removed stones and occurrence of a possible co-relationship between the incidence of the urinary stone disease at different times, age, sex, religion of the patients was investigated. Results: The frequency of occurrence of urinary stones in males was found to be almost three times more as compared to their female counterparts. The above trend was consistent over the entire period of the study. Interestingly, in the Muslim and Sikh population of the area, females were found to be less prone to the problem as compared to their Hindu counterparts.  However, in all religious groups, 21-40 years old subjects were found to be most susceptible to the problem and approximately 90% of the urinary stones were recovered from the kidneys and primarily composed of calcium oxalate. Conclusion: The co-relationship between the occurrence of urinary stones with age, sex of the patients, their religion & site of stones on diagnosis was found to be statistically significant.  Keywords: Urolithiasis, Urinary Stone disease, Urinary calculus, Renal stones.

In vitro evidence supporting the prophylactic use of citrate in urinary stone disease

2003 ◽  
Vol 2 (1) ◽  
pp. 79
Author(s):  
K. Chow ◽  
J. Dixon ◽  
S. Gilpin ◽  
J.P. Kavanagh ◽  
P.N. Rao
Keyword(s):  
Urinary Stone ◽  
Stone Disease ◽  
Urinary Stone Disease ◽  
Prophylactic Use
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