Effects of Poncirus trifoliata on Type I Hypersensitivity Reaction

A study was carried out to examine the effect of an aqueous extract from immature fruit of Poncirus trifoliata L. (Rutaceae) (PTIFE) on the type I hypersensitivity reaction. Forty-eight hour PCA (passive cutaneous anaphylaxis) in rats was significantly inhibited by the oral administration of PTIFE (200 mg/kg). It also inhibited histamine release from rat peritoneal mast cells (RPMC) induced by mouse anti-dinitrophenyl (DNP)-lgE and dinitrophenyl-human serum albumin (DNP-HSA). These results suggest that PTIFE has anti-allergic action against the type I hypersensitivity reaction.

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Effects of Siegesbeckia pubescens on Immediate Hypersensitivity Reaction

The American Journal of Chinese Medicine ◽

10.1142/s0192415x97000184 ◽

1997 ◽

Vol 25 (02) ◽

pp. 163-167 ◽

Cited By ~ 12

Author(s):

Hyung Min Kim

Keyword(s):

Mast Cells ◽

Hypersensitivity Reaction ◽

Histamine Release ◽

Immunoglobulin E ◽

Immediate Hypersensitivity ◽

Antiallergic Activity ◽

Peritoneal Mast Cells ◽

Ige Mediated ◽

Rat Peritoneal Mast Cells ◽

Siegesbeckia Pubescens

This study was carried out to examine the effect of an aqueous extract from Siegesbeckia pubescens (Compositae) (SPAE) on immunoglobulin E (IgE)-mediated immediate hypersensitivity reaction. Forty-eight hours passive cutaneous anaphylaxis in rats was significantly inhibited by oral administration of SPAE (100 μg/g). It also inhibited histamine release from rat peritoneal mast cells induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin. The data indicate that SPAE has antiallergic activity, and that its action may be due to inhibition of histamine release from mast cells.

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Effects of type I and type II phospholipase A2 on rat peritoneal mast cells

Inflammation Research ◽

10.1007/bf01674369 ◽

1995 ◽

Vol 44 (S1) ◽

pp. S5-S6 ◽

Cited By ~ 1

Author(s):

C. M. Roche ◽

H. Y. A. Lau ◽

R. L. Jones ◽

C. K. W. Lai

Keyword(s):

Mast Cells ◽

Phospholipase A2 ◽

Type I ◽

Type Ii ◽

Peritoneal Mast Cells ◽

Rat Peritoneal Mast Cells

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Protein and Antibody Engineering: Suppressing Degranulation of the Mast Cells and Type I Hypersensitivity Reaction

Current Protein and Peptide Science ◽

10.2174/1389203721666200511094717 ◽

2020 ◽

Vol 21 (8) ◽

pp. 831-841

Author(s):

Huda Fatima Rajani ◽

Solmaz Shahidi ◽

Mohammad Mahmoudi Gomari

Keyword(s):

Mast Cells ◽

Hypersensitivity Reaction ◽

Review Paper ◽

Antibody Engineering ◽

Type I ◽

Hypersensitivity Response ◽

Ige Mediated ◽

Biological Environment ◽

Type I Hypersensitivity

With an increase in atopic cases and owing to a significant role of mast cells in type I hypersensitivity, a therapeutic need to inhibit degranulation of mast cells has risen. Mast cells are notorious for IgE-mediated allergic response. Advancements have allowed researchers to improve clinical outcomes of already available therapies. Engineered peptides and antibodies can be easily manipulated to attain desired characteristics as per the biological environment. A number of these molecules are designed to target mast cells in order to regulate the release of histamine and other mediators, thereby controlling type I hypersensitivity response. The aim of this review paper is to highlight some of the significant molecules designed for the purpose.

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