A Systems Security Analysis of Issuance and Verification of Birth Documents Enhanced with DNA Profiles

2017 ◽  
Vol 17 (01) ◽  
pp. 1740003
Author(s):  
MARK F. TANNIAN ◽  
CHRISTINA SCHWEIKERT ◽  
YING LIU

The use of biometrics to enhance identification has been explored and utilized to various extents. DNA is the most reliable and stable biometric that remains unchanged throughout an individual’s lifetime. Advancements in DNA analysis, in terms of reduced cost and faster processing times, make the use of DNA as a biometric more feasible over time. Since DNA data is of a sensitive nature, privacy and ethical concerns would have to be carefully considered before large-scale adoption for use in identity documents. Birth certificates are a fundamental document used by a person for identification. However, it does not contain any means of authentication beyond possession of the document. This paper examines the security measures that would be required if birth certificates were embedded with DNA profile information. The U.S. FBI CODIS approach is referred to, being an established standard for human DNA profiling and identification. Effects on the issuance and verification network for birth certificate documents are explored, in addition to the security threats.

2020 ◽  
Author(s):  
Jacob A. Blindenbach ◽  
Karthik A. Jagadeesh ◽  
Gill Bejerano ◽  
David J. Wu

AbstractThe presumption of innocence (i.e., the principle that one is considered innocent until proven guilty) is a cornerstone of the criminal justice system in many countries, including the United States. DNA analysis is an important tool for criminal investigations1. In the U.S. alone, it has already aided in over half a million investigations using the Combined DNA Index System (CODIS) and associated DNA databases2. CODIS includes DNA profiles of crime scene forensic samples, convicted offenders, missing persons and more. The CODIS framework is currently used by over 50 other countries3 including much of Europe, Canada, China and more. During investigations, DNA samples can be collected from multiple individuals who may have had access to, or were found near a crime scene, in the hope of finding a single criminal match4. Controversially, CODIS samples are sometimes retained from adults and juveniles despite not yielding any database match4–6. Here we introduce a cryptographic algorithm that finds any and all matches of a person’s DNA profile against a CODIS database without revealing anything about the person’s profile to the database provider. With our protocol, matches are immediately identified as before; however, individuals who do not match anything in the database retain their full privacy. Our novel algorithm runs in 40 seconds on a CODIS database of 1,000,000 entries, enabling its use to privately screen potentially-innocent suspects even in the field.


2021 ◽  
Vol 1 (3) ◽  
pp. 116-129
Author(s):  
Louise Wallis ◽  
Catherine Hitchcock ◽  
Dennis McNevin ◽  
Jennifer Raymond

ABAcard® HemaTrace® kits have been used for crime scene stains for confirmation of human blood for many years. However, when the stain is too small to allow for separate testing, confirmatory testing may be forgone to preference DNA analysis. This can lead to court challenges as to the biological source and therefore probative value of the DNA profile. This research aimed to develop a protocol for DNA analysis of a minute blood stain subsequent to HemaTrace® testing. Stains were collected and subjected to HemaTrace® testing. Swabs were then removed from the HemaTrace® buffer solution and processed. DNA yields and STR DNA profiles were analysed for both quantity and quality. Full profiles were reliably obtained from stains with diameters of 0.6 mm–0.7 mm, reflecting DNA concentrations between 0.0036 ng/μL and 0.007 ng/μL, varying according to substrate characteristics. However, stains below a diameter of 0.6 mm should proceed directly for DNA profiling. This protocol was also successfully performed on blood stains which had undergone UV irradiation, although use of the reporting peak height threshold (lower than the routine analytical threshold) was required to obtain useable profiles. We have been able to demonstrate a protocol which, with minor adjustments to crime scene procedures, allows for both the confirmation of the presence of human blood, together with the generation of useful DNA profiles.


1997 ◽  
Vol 77 (03) ◽  
pp. 436-439 ◽  
Author(s):  
Armando Tripodi ◽  
Barbara Negri ◽  
Rogier M Bertina ◽  
Pier Mannuccio Mannucci

SummaryThe factor V (FV) mutation Q506 that causes resistance to activated protein C (APC) is the genetic defect associated most frequently with venous thrombosis. The laboratory diagnosis can be made by DNA analysis or by clotting tests that measure the degree of prolongation of plasma clotting time upon addition of APC. Home-made and commercial methods are available but no comparative evaluation of their diagnostic efficacy has so far been reported. Eighty frozen coded plasma samples from carriers and non-carriers of the FV: Q506 mutation, diagnosed by DNA analysis, were sent to 8 experienced laboratories that were asked to analyze these samples in blind with their own APC resistance tests. The APTT methods were highly variable in their capacity to discriminate between carriers and non-carriers but this capacity increased dramatically when samples were diluted with FV-deficient plasma before analysis, bringing the sensitivity and specificity of these tests to 100%. The best discrimination was obtained with methods in which fibrin formation is triggered by the addition of activated factor X or Russell viper venom. In conclusion, this study provides evidence that some coagulation tests are able to distinguish carriers of the FV: Q506 mutation from non-carriers as well as the DNA test. They are inexpensive and easy to perform. Their use in large-scale clinical trials should be of help to determine the medical and economic benefits of screening healthy individuals for the mutation before they are exposed to such risk factors for venous thrombosis as surgery, pregnancy and oral contraceptives.


2020 ◽  
Vol 17 (1) ◽  
pp. 319-328
Author(s):  
Ade Muchlis Maulana Anwar ◽  
Prihastuti Harsani ◽  
Aries Maesya

Population Data is individual data or aggregate data that is structured as a result of Population Registration and Civil Registration activities. Birth Certificate is a Civil Registration Deed as a result of recording the birth event of a baby whose birth is reported to be registered on the Family Card and given a Population Identification Number (NIK) as a basis for obtaining other community services. From the total number of integrated birth certificate reporting for the 2018 Population Administration Information System (SIAK) totaling 570,637 there were 503,946 reported late and only 66,691 were reported publicly. Clustering is a method used to classify data that is similar to others in one group or similar data to other groups. K-Nearest Neighbor is a method for classifying objects based on learning data that is the closest distance to the test data. k-means is a method used to divide a number of objects into groups based on existing categories by looking at the midpoint. In data mining preprocesses, data is cleaned by filling in the blank data with the most dominating data, and selecting attributes using the information gain method. Based on the k-nearest neighbor method to predict delays in reporting and the k-means method to classify priority areas of service with 10,000 birth certificate data on birth certificates in 2019 that have good enough performance to produce predictions with an accuracy of 74.00% and with K = 2 on k-means produces a index davies bouldin of 1,179.


Radiation ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 79-94
Author(s):  
Peter K. Rogan ◽  
Eliseos J. Mucaki ◽  
Ben C. Shirley ◽  
Yanxin Li ◽  
Ruth C. Wilkins ◽  
...  

The dicentric chromosome (DC) assay accurately quantifies exposure to radiation; however, manual and semi-automated assignment of DCs has limited its use for a potential large-scale radiation incident. The Automated Dicentric Chromosome Identifier and Dose Estimator (ADCI) software automates unattended DC detection and determines radiation exposures, fulfilling IAEA criteria for triage biodosimetry. This study evaluates the throughput of high-performance ADCI (ADCI-HT) to stratify exposures of populations in 15 simulated population scale radiation exposures. ADCI-HT streamlines dose estimation using a supercomputer by optimal hierarchical scheduling of DC detection for varying numbers of samples and metaphase cell images in parallel on multiple processors. We evaluated processing times and accuracy of estimated exposures across census-defined populations. Image processing of 1744 samples on 16,384 CPUs required 1 h 11 min 23 s and radiation dose estimation based on DC frequencies required 32 sec. Processing of 40,000 samples at 10 exposures from five laboratories required 25 h and met IAEA criteria (dose estimates were within 0.5 Gy; median = 0.07). Geostatistically interpolated radiation exposure contours of simulated nuclear incidents were defined by samples exposed to clinically relevant exposure levels (1 and 2 Gy). Analysis of all exposed individuals with ADCI-HT required 0.6–7.4 days, depending on the population density of the simulation.


2021 ◽  
Vol 11 (4) ◽  
pp. 1943
Author(s):  
Joo-Young Kim ◽  
Ju Yeon Jung ◽  
Da-Hye Kim ◽  
Seohyun Moon ◽  
Won-Hae Lee ◽  
...  

Analytical techniques such as DNA profiling are widely used in various fields, including forensic science, and novel technologies such as direct polymerase chain reaction (PCR) amplification are continuously being developed in order to acquire DNA profiles efficiently. However, non-specific amplification may occur depending on the quality of the crime scene evidence and amplification methods employed. In particular, the ski-slope effect observed in direct PCR amplification has led to inaccurate interpretations of the DNA profile results. In this study, we aimed to reduce the ski-slope effect by using dimethyl sulfoxide (DMSO) in direct PCR. We confirmed that DMSO (3.75%, v/v) increased the amplification yield of large-sized DNA sequences more than that of small-sized ones. Using 50 Korean buccal samples, we further demonstrated that DMSO reduced the ski-slope effect in direct PCR. These results suggest that the experimental method developed in this study is suitable for direct PCR and may help to successfully obtain DNA profiles from various types of evidence at crime scenes.


Network ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 75-94
Author(s):  
Ed Kamya Kiyemba Edris ◽  
Mahdi Aiash ◽  
Jonathan Loo

Fifth Generation mobile networks (5G) promise to make network services provided by various Service Providers (SP) such as Mobile Network Operators (MNOs) and third-party SPs accessible from anywhere by the end-users through their User Equipment (UE). These services will be pushed closer to the edge for quick, seamless, and secure access. After being granted access to a service, the end-user will be able to cache and share data with other users. However, security measures should be in place for SP not only to secure the provisioning and access of those services but also, should be able to restrict what the end-users can do with the accessed data in or out of coverage. This can be facilitated by federated service authorization and access control mechanisms that restrict the caching and sharing of data accessed by the UE in different security domains. In this paper, we propose a Data Caching and Sharing Security (DCSS) protocol that leverages federated authorization to provide secure caching and sharing of data from multiple SPs in multiple security domains. We formally verify the proposed DCSS protocol using ProVerif and applied pi-calculus. Furthermore, a comprehensive security analysis of the security properties of the proposed DCSS protocol is conducted.


Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1336
Author(s):  
Caterina Catalano ◽  
Loredana Abbate ◽  
Antonio Motisi ◽  
Dalila Crucitti ◽  
Vincenzo Cangelosi ◽  
...  

Polyploidy plays an important role in plant adaptation to biotic and abiotic stresses. Alterations of the ploidy in grapevine plants regenerated via somatic embryogenesis (SE) may provide a source of genetic variability useful for the improvement of agronomic characteristics of crops. In the grapevine, the SE induction process may cause ploidy changes without alterations in DNA profile. In the present research, tetraploid plants were observed for 9.3% of ‘Frappato’ grapevine somatic embryos regenerated in medium supplemented with the growth regulators β-naphthoxyacetic acid (10 µM) and N6-benzylaminopurine (4.4 µM). Autotetraploid plants regenerated via SE without detectable changes in the DNA profiles were transferred in field conditions to analyze the effect of polyploidization. Different ploidy levels induced several anatomical and morphological changes of the shoots and mature leaves. Alterations have been also observed in stomata. The length and width of stomata of tetraploid leaves were 39.9 and 18.6% higher than diploids, respectively. The chloroplast number per guard cell pair was higher (5.2%) in tetraploid leaves. On the contrary, the stomatal index was markedly decreased (12%) in tetraploid leaves. The observed morphological alterations might be useful traits for breeding of grapevine varieties in a changing environment.


2021 ◽  
Author(s):  
Edwin Lughofer ◽  
Mahardhika Pratama

AbstractEvolving fuzzy systems (EFS) have enjoyed a wide attraction in the community to handle learning from data streams in an incremental, single-pass and transparent manner. The main concentration so far lied in the development of approaches for single EFS models, basically used for prediction purposes. Forgetting mechanisms have been used to increase their flexibility, especially for the purpose to adapt quickly to changing situations such as drifting data distributions. These require forgetting factors steering the degree of timely out-weighing older learned concepts, whose adequate setting in advance or in adaptive fashion is not an easy and not a fully resolved task. In this paper, we propose a new concept of learning fuzzy systems from data streams, which we call online sequential ensembling of fuzzy systems (OS-FS). It is able to model the recent dependencies in streams on a chunk-wise basis: for each new incoming chunk, a new fuzzy model is trained from scratch and added to the ensemble (of fuzzy systems trained before). This induces (i) maximal flexibility in terms of being able to apply variable chunk sizes according to the actual system delay in receiving target values and (ii) fast reaction possibilities in the case of arising drifts. The latter are realized with specific prediction techniques on new data chunks based on the sequential ensemble members trained so far over time. We propose four different prediction variants including various weighting concepts in order to put higher weights on the members with higher inference certainty during the amalgamation of predictions of single members to a final prediction. In this sense, older members, which keep in mind knowledge about past states, may get dynamically reactivated in the case of cyclic drifts, which induce dynamic changes in the process behavior which are re-occurring from time to time later. Furthermore, we integrate a concept for properly resolving possible contradictions among members with similar inference certainties. The reaction onto drifts is thus autonomously handled on demand and on the fly during the prediction stage (and not during model adaptation/evolution stage as conventionally done in single EFS models), which yields enormous flexibility. Finally, in order to cope with large-scale and (theoretically) infinite data streams within a reasonable amount of prediction time, we demonstrate two concepts for pruning past ensemble members, one based on atypical high error trends of single members and one based on the non-diversity of ensemble members. The results based on two data streams showed significantly improved performance compared to single EFS models in terms of a better convergence of the accumulated chunk-wise ahead prediction error trends, especially in the case of regular and cyclic drifts. Moreover, the more advanced prediction schemes could significantly outperform standard averaging over all members’ outputs. Furthermore, resolving contradictory outputs among members helped to improve the performance of the sequential ensemble further. Results on a wider range of data streams from different application scenarios showed (i) improved error trend lines over single EFS models, as well as over related AI methods OS-ELM and MLPs neural networks retrained on data chunks, and (ii) slightly worse trend lines than on-line bagged EFS (as specific EFS ensembles), but with around 100 times faster processing times (achieving low processing times way below requiring milli-seconds for single samples updates).


Sign in / Sign up

Export Citation Format

Share Document