DIFFUSION MRI-BASED FIBER TRACKING IN HEALTHY AND BRAIN INJURY PATIENTS: A COMPARISON OF DIFFERENT SOFTWARE TOOLS

2015 ◽  
Vol 15 (02) ◽  
pp. 1540020
Author(s):  
GIULIA LUCCONI ◽  
CHIARA ROMEO ◽  
ROBERTO BONETTI ◽  
PATRIZIA CENNI ◽  
NICOLETTA SCRITTORI
Keyword(s):  
Brain Injury ◽  
Corpus Callosum ◽  
Corticospinal Tract ◽  
Preoperative Imaging ◽  
Brain Images ◽  
Non Invasive ◽  
Imaging Tool ◽  
Termination Criteria ◽  
Fibers Orientation ◽  
Deterministic And Probabilistic Approaches

In this work, we compared different DTI-based fibertracking software using deterministic and probabilistic approaches. DTI brain images of 35 healthy and five brain-injury patients were acquired with Philips Achieva 1.5 T scanner using an EPI-SE DTI sequence with 16 diffusion directions. Images were analyzed with Philips FiberTrack module, DTI-Studio and FSL. We studied corticospinal tract and corpus callosum, considering different termination criteria for the fibertracking algorithm. Group studies were performed to create a database of healthy patients. Results of FSL fibertracking with 1 or 2 fibers per voxel were no statistically different. T-tests between Philips and DTI-Studio led to p-values > 0.01 for corticospinal tract and < 0.01 for corpus callosum. FSL analysis led to higher ADC and lower FA values, with significative differences with the other software. In brain injury patients we measured different fibers orientation, reduced FA and increased ADC around the lesion. In conclusion, although DTI fibertracking is a promising non-invasive preoperative imaging tool, the outcome is strongly influenced by the algorithm used and the parameters chosen for the seed generation and fiber propagation.

scholarly journals 49-06: Using electromechanical wave imaging, a novel non-invasive ultrasound imaging tool to detect endocardial versus epicardial arrhythmia origins

EP Europace ◽  
2016 ◽  
Vol 18 (suppl_1) ◽  
pp. i31-i31
Author(s):  
Elaine Wan ◽  
Alexander Costet ◽  
Ethan Bunting ◽  
Julien Grondin ◽  
Hasan Garan ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Non Invasive ◽  
Imaging Tool ◽  
Wave Imaging

The original method for corpus callosum autopsy study in the case of diffuse axonal brain injury

2021 ◽  
Vol 64 (3) ◽  
pp. 45
Author(s):  
O.V. Zorikov ◽  
E.S. Tuchik ◽  
E.M. Koludarova ◽  
P.S. Sumenkov
Keyword(s):  
Brain Injury ◽  
Corpus Callosum ◽  
Original Method ◽  
Autopsy Study

scholarly journals Segmentation of Brain Images by Optimizing Clustering of Convolution Based Features

2021 ◽  
Vol 229 ◽  
pp. 01034
Author(s):  
Vikas Kumar
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Normal Brain ◽  
Resonance Imaging ◽  
Comprehensive Overview ◽  
Brain Images ◽  
Non Invasive ◽  
Tumour Segmentation ◽  
Tissue Contrast ◽  
Brain Tumour Segmentation

Brain tumour segmentation aims to separate the various types of tumour tissues like active cells, necrotic core, and edema from normal brain tissues of substantia alba (WM), grey matter (GM), and spinal fluid (CSF). Magnetic Resonance Imaging based brain tumour segmentation studies are attracting more and more attention in recent years thanks to non-invasive imaging and good soft tissue contrast of resonance Imaging (MRI) images. With the event of just about two decades, the ingenious approaches applying computer-aided techniques for segmenting brain tumour are getting more and more mature and coming closer to routine clinical applications. the aim of this paper is to supply a comprehensive overview for MRIbased brain tumour segmentation methods. Firstly, a quick introduction to brain tumours and imaging modalities of brain tumours is given in this proposed research, convolution based optimization. These stepwise step refine the segmentation and improve the classification parameter with the assistance of particle swarmoptimization.

Corpus Callosum Vasculature Predicts White Matter Microstructure Abnormalities after Pediatric Mild Traumatic Brain Injury

2019 ◽  
Vol 36 (1) ◽  
pp. 152-164 ◽  
Author(s):  
Kara M. Wendel ◽  
Jeong Bin Lee ◽  
Bethann M. Affeldt ◽  
Mary Hamer ◽  
Indira S. Harahap-Carrillo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Corpus Callosum ◽  
Mild Traumatic Brain Injury ◽  
White Matter Microstructure

The role of non-invasive brain oximetry in adult critically ill patients without primary brain injury

2021 ◽  
Author(s):  
Rafael Badenes ◽  
Elisa G. Bogossian ◽  
Vicente Chisbert ◽  
Chiara Robba ◽  
Mauro Oddo ◽  
...  
Keyword(s):  
Brain Injury ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Non Invasive

Abstract WP288: Inter-Alpha Inhibitor Proteins Reduce the Presence of Neutrophils and Matrix Metalloproteinase-9 Positive Neutrophils in Damaged Brain Regions of Neonates with Hypoxic-Ischemic (HI) Brain Injury

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Adriel Barrios-Anderson ◽  
Xiaodi Chen ◽  
Yow-Pin Lim ◽  
Barbara S Stonestreet
Keyword(s):  
Brain Injury ◽  
Corpus Callosum ◽  
Matrix Metalloproteinase ◽  
Right Hemisphere ◽  
Brain Regions ◽  
Matrix Metalloproteinase 9 ◽  
Male Rats ◽  
Control Group ◽  
Neonatal Rats ◽  
Metalloproteinase 9

Introduction: Inter-alpha inhibitor proteins (IAIPs) are immunomodulatory proteins that play a significant anti-inflammatory role in hypoxic ischemic (HI) brain injury. We have shown that administering IAIPs after HI improves histopathological brain injury, brain weight, and behavioral outcomes in neonatal rats. Neutrophils are specialized leukocytes known to infiltrate the brain parenchyma and exacerbate neuronal injury after HI. One molecular mechanism by which neutrophils exert damage on the blood-brain barrier (BBB) and brain tissue after ischemia is by the release of matrix metalloproteinase-9 (MMP9), an enzyme that breaks down the extracellular matrices of surrounding cells. Objective: To determine the effect of IAIPs on neutrophil infiltration and release of MMP9 in neonatal rats after HI. Methods: The Vannucci model was used to induce neonatal HI in postnatal day 7 rats that were assigned to a Non-ischemic sham-control group (Sham, n=12), right-sided carotid ligation with exposure to hypoxia (8% oxygen for 90 min) treated with placebo group (PL-HI, n=17), or an IAIP treated group (IAIP-HI, n=17). Rat sex was recorded. IAIP (30 mg/kg) or PL was given intraperitoneally at 0, 24 and 48 h after HI. We removed the rat brain after 72h and performed immunohistochemistry using MPO (neutrophil selective) and MMP9 fluorescent markers. We performed stereological analyses with the StereoInvestigator 10.0 Fractionator probe without knowledge of group assignment to quantify neutrophils and MMP9 positive cells present within the right hemisphere, cortex, corpus callosum, and hippocampus. Results: MPO positive cells were significantly reduced in male IAIP treated rats compared with PL-HI in the overall damaged hemisphere (p<0.01) and the corpus callosum (p<0.05). Further, we observed MPO and MMP9 co-localization, and IAIP treatment reduced the presence of MMP9 positive neutrophils in the cortex of male rats compared to placebo (P<0.05).

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